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Entry version 44 (29 Sep 2021)
Sequence version 1 (21 Mar 2012)
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Protein
Submitted name:

Upstream transcription factor family member 3

Gene

USF3

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Upstream transcription factor family member 3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:USF3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9601 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001595 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9601.ENSPPYP00000015137

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini18 – 69BHLHInterPro annotationAdd BLAST52

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 28DisorderedSequence analysisAdd BLAST28
Regioni447 – 471DisorderedSequence analysisAdd BLAST25
Regioni877 – 933DisorderedSequence analysisAdd BLAST57
Regioni1015 – 1039DisorderedSequence analysisAdd BLAST25
Regioni1165 – 1201DisorderedSequence analysisAdd BLAST37
Regioni1307 – 1331DisorderedSequence analysisAdd BLAST25
Regioni1420 – 1441DisorderedSequence analysisAdd BLAST22
Regioni1488 – 1618DisorderedSequence analysisAdd BLAST131
Regioni1730 – 1758DisorderedSequence analysisAdd BLAST29
Regioni1771 – 1809DisorderedSequence analysisAdd BLAST39
Regioni1831 – 1853DisorderedSequence analysisAdd BLAST23
Regioni1888 – 2025DisorderedSequence analysisAdd BLAST138

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili82 – 109Sequence analysisAdd BLAST28
Coiled coili1459 – 1479Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 15Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi877 – 928Polar residuesSequence analysisAdd BLAST52
Compositional biasi1181 – 1201Polar residuesSequence analysisAdd BLAST21
Compositional biasi1491 – 1537Polar residuesSequence analysisAdd BLAST47
Compositional biasi1548 – 1618Polar residuesSequence analysisAdd BLAST71
Compositional biasi1795 – 1809Polar residuesSequence analysisAdd BLAST15
Compositional biasi1831 – 1852Polar residuesSequence analysisAdd BLAST22
Compositional biasi1888 – 1932Polar residuesSequence analysisAdd BLAST45
Compositional biasi1956 – 2005Polar residuesSequence analysisAdd BLAST50

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QVK9, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000015759

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001249_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
H2P9P8

Identification of Orthologs from Complete Genome Data

More...
OMAi
CPPTHES

TreeFam database of animal gene trees

More...
TreeFami
TF332661

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
4.10.280.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011598, bHLH_dom
IPR036638, HLH_DNA-bd_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00010, HLH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00353, HLH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47459, SSF47459, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50888, BHLH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

H2P9P8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPEMTENETP TKKQHRKKNR ETHNAVERHR KKKINAGINR IGELIPCSPA
60 70 80 90 100
LKQSKNMILD QAFKYITELK RQNDELLLNG GNNEQAEEIK KLRKQLEEIQ
110 120 130 140 150
KENGRYIELL KANDICLYDD PTIHWKGNLK NSKVSVVIPS DQVQKNIIVY
160 170 180 190 200
SNGNQPGGNS QGTAVQGITF NVSHNLQKQT ANVVPVQRTC NLVTPVSISG
210 220 230 240 250
VYPSENKPWH QTTVPALATN QPVPLCLPAA ISAQSILELP TSESESNVLG
260 270 280 290 300
ATSGSLIAVS IGSEPHQHHS LHTCLNDQNS FENKNGQENP KLLKKMTPCV
310 320 330 340 350
TNIPHSSSAT ATKVHHGNKS CLSIQDFRGD FQNTFVVSVN TTVCSQPPRT
360 370 380 390 400
ADDSSPMIIS KSADLTSTAT VVASSAPGVG KATIPVSTLS GNPLDNGWTL
410 420 430 440 450
SCSLPSSSVS TSDLKNINSL TRISSAGNTQ TTWTTLQLAG NTIQPLSQTP
460 470 480 490 500
SSAVTPVLNE SGTSPTTSNH SRHVATGINL NNSFPADGQP VEQVVVTLPS
510 520 530 540 550
CPSLPMQPLI AQPQVKSQPP KNILPLNSAM QVIQMAQPVG SAVNAAPANQ
560 570 580 590 600
NVIILQPPST TPCPTVMRAE VPNQTVGQQI VIIQAANQNP LPLLPAPPPG
610 620 630 640 650
SVRLPINGAN TVIGSNNSVQ NVPTPQTFGG KHLVHILPRP SSLSASSSTQ
660 670 680 690 700
TFSVTMSNQQ PQTISLNGQL FALQPVMSSS GTTNQTPMQI IQPTTSEDPN
710 720 730 740 750
TNVALNTFGA LASLNQSISQ MAGQSCVQLS ISQPANAQTA ANSQTTTANC
760 770 780 790 800
VSLTTTAAPP VTTDSSATLA STYNLVSTSS MNTVACLPNM KSKRLNKKPG
810 820 830 840 850
ARKHLAANKS ACPLNSVRDV SKLDCPNTEG SAEPSCNDGL LESFPAVLPS
860 870 880 890 900
VSMSQANSVS VSASHSLGVL SSESLIPESV SKSKSAEKSS PPSQESVMSE
910 920 930 940 950
HFAMATAKSK DSTPNLQQET SQDKPPSSLA LSDAAKPCTS ANVLIPSPSD
960 970 980 990 1000
PHILVSQVSG LSSTTSTTST DCVSEVEIIA EPCRVEQDSS DTMQTTGLLK
1010 1020 1030 1040 1050
GQGLTTLLSD LAKKKNPQKS SLSDQMDHPD FSSENPKIVD SSVNLHPKQE
1060 1070 1080 1090 1100
LLLMNNDDRD PPQHHSCLPD QEVINGSLIT GRQADSPMST SSGSSRSFSV
1110 1120 1130 1140 1150
ASMLPETTRE DVTSNATTNT CDSCTFVEQT DIVALAARAI FDQENLEKGR
1160 1170 1180 1190 1200
VGLQADIREV ASKPSEASLL EGHPPFKSQI PKENGTGQAE ATSNEFNSQG
1210 1220 1230 1240 1250
SIEATVERTL EKPSCSLGIK TSNASLQDST SQPPSITSLS VNNLIHQSSI
1260 1270 1280 1290 1300
SHPLASCAGL SPTSEQTTVP ATVNLTISSS SYGSQPPGPS LMTEYSQEQL
1310 1320 1330 1340 1350
NTMTSTIPNS QIQEPLLKPS HESRKDSAKR AVQDDLLLSS AKRQKHCQPA
1360 1370 1380 1390 1400
PLRLESMSLM SRTPDTISDQ TQIMVSQIPP NSSNSVVPVS NPAHGDGLTR
1410 1420 1430 1440 1450
LFPPSNNFVA PALRQTEVQC GSQPSVAEQQ QTQASQHLQA LQQHVPAQGV
1460 1470 1480 1490 1500
SHLHSNHLYI KQQQQQQQQQ QQAGQLRERH HLYQMQHHVP HAESSVHSQP
1510 1520 1530 1540 1550
HNVHQQRTLQ QEVQMQKKRN LVQGTQTSQL SLQPKHHGTD QSRSKSGQPH
1560 1570 1580 1590 1600
PHHQQMQQQM QQHFGSSQTE KSCENPSTSR NHHNHPQNHL NQDIMHQQQE
1610 1620 1630 1640 1650
VGSRQQGSGV SSEHVSGHNP MQRLLTSRGL EQQIVSQPSI VTRSSDMTCT
1660 1670 1680 1690 1700
PHRPERNRVS SYSAEALIGK TSSNSEQRMG ISIQGSRVSD QLEMRSYLDV
1710 1720 1730 1740 1750
PRNKSLAIHN MQGRVDHTVA SDIRLSDCQT FKPSGASQQP QSNFEVQSSR
1760 1770 1780 1790 1800
NNEIGNPVSS LRSMQSQAFR ISQNTGPPPI DRQKRLPYPP VQSIPTGNGI
1810 1820 1830 1840 1850
PSRDSENTCH QSFMQSLLAP HLSDQVIGSQ RSLSEHQRNT QCGTSSAIEY
1860 1870 1880 1890 1900
NCPPTHENVH IRRESESQNR ESCDMSLGAI NARNSTLNIP FSSSSSSGDI
1910 1920 1930 1940 1950
QGRNTSPNVS VQKSNPMRIT DSHATKGHMN PPVTTNMHGV ARPALPHPSV
1960 1970 1980 1990 2000
SHGNGDQGPA VRQANSSVPQ RSRHPLQDSS GSKIRQPERN RSGNQRQSTV
2010 2020 2030 2040 2050
FDPSLPHLPL STGGSMILGR QQPATEKRGS IVRFMPDSPQ VPNDNSGPDQ
2060 2070 2080 2090 2100
HTLSQNFGFS FIPEGGMNPP INANASFIPQ VTQPSATRTP ALIPVDPQNT
2110 2120 2130 2140 2150
LPSFYPPYSP AHPTLSNDIS IPYFPNQMFS NPSTEKVNSG SLNNRFGSIL
2160 2170 2180 2190 2200
SPPRPVGFAQ PSFPLLPDMP PMHMTNSHLS NFNMTSLFPE IATALPDGSA
2210 2220 2230
MSPLLTIANS SASDSSKQSS NRPAHNISHI LGHDCSSAV
Length:2,239
Mass (Da):240,824
Last modified:March 21, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2A3BABEFA4EBE393
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EVW8K7EVW8_PONAB
Upstream transcription factor famil...
USF3
2,183Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSPPYT00000015742; ENSPPYP00000015137; ENSPPYG00000013537

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000015137

Genome annotation databases

EnsembliENSPPYT00000015742; ENSPPYP00000015137; ENSPPYG00000013537

Phylogenomic databases

eggNOGiENOG502QVK9, Eukaryota
GeneTreeiENSGT00390000015759
HOGENOMiCLU_001249_0_0_1
InParanoidiH2P9P8
OMAiCPPTHES
TreeFamiTF332661

Family and domain databases

Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598, bHLH_dom
IPR036638, HLH_DNA-bd_sf
PfamiView protein in Pfam
PF00010, HLH, 1 hit
SMARTiView protein in SMART
SM00353, HLH, 1 hit
SUPFAMiSSF47459, SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888, BHLH, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH2P9P8_PONAB
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H2P9P8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 21, 2012
Last sequence update: March 21, 2012
Last modified: September 29, 2021
This is version 44 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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