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Protein
Submitted name:

BRCA1 interacting protein C-terminal helicase 1

Gene

BRIP1

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Catalytic activityi

ATP + H2O = ADP + phosphate.SAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHelicaseSAAS annotation, Hydrolase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
BRCA1 interacting protein C-terminal helicase 1Imported
Submitted name:
BRIP1 isoform 1Imported
Gene namesi
Name:BRIP1Imported
ORF Names:CR201_G0012038Imported
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)Imported
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
Proteomesi
  • UP000001595 Componenti: Chromosome 17

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000009883

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 442Helicase ATP-bindingInterPro annotationAdd BLAST432

Phylogenomic databases

eggNOGiKOG1132 Eukaryota
COG1199 LUCA
GeneTreeiENSGT00530000063199
InParanoidiH2NV90
OMAiTNNDMNQ
OrthoDBiEOG091G00LK
TreeFamiTF329449

Family and domain databases

InterProiView protein in InterPro
IPR006555 ATP-dep_Helicase_C
IPR010614 DEAD_2
IPR014013 Helic_SF1/SF2_ATP-bd_DinG/Rad3
IPR006554 Helicase-like_DEXD_c2
IPR014001 Helicase_ATP-bd
IPR027417 P-loop_NTPase
IPR013020 Rad3/Chl1-like
PfamiView protein in Pfam
PF06733 DEAD_2, 1 hit
PF13307 Helicase_C_2, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00488 DEXDc2, 1 hit
SM00491 HELICc2, 1 hit
SUPFAMiSSF52540 SSF52540, 6 hits
TIGRFAMsiTIGR00604 rad3, 1 hit
PROSITEiView protein in PROSITE
PS51193 HELICASE_ATP_BIND_2, 1 hit

Sequencei

Sequence statusi: Complete.

H2NV90-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSVWSEYTI GGVKIYFPYK AYPSQLAMMN SILRGLNSKQ HCLLESPTGS
60 70 80 90 100
GKSLALLCSA LAWQQSLSGK PADEDVSEKA EVPSSCCCTC HSKDFTNNDM
110 120 130 140 150
NQGTSHHFNY PSTPPSERNG TSSTCQDSPE KTTLAAKLSA KKQASVYRNE
160 170 180 190 200
NDDFQVEKKR IRPLETTQQI RKRHCFGTEV HNLDAKVDSG KTVKLNSPLG
210 220 230 240 250
KINSFLPQKT PGHCSRCCCS TKQGNSQESS NTIKKDHTGK SKIPKIYFGT
260 270 280 290 300
RTHKQIAQIT RELRRTAYSG VPMTILSSRD HTCVHPEAVG NFNRNEKCME
310 320 330 340 350
LLDGKNGKSC YFYHGVHKIS DQHTLQTFQG MCKAWDIEEL VSLGKKIKAC
360 370 380 390 400
PYYTARELIQ DADIIFCPYN YLLDAQIRES MDLNLKEQVV ILDEAHNIED
410 420 430 440 450
CARESASYSV TEVQLRFARD ELDSMVNNNI RKKDHEPLRA VCYSLINWLE
460 470 480 490 500
ANSEYLVERD YESACKIWSG NEMLLTLHKM GITTATFPIL QGHFSAVLQK
510 520 530 540 550
EEKILPIYGK EETREVPVIS ASTQIMLKGL FMVLDYLFRQ NSRFADDYKI
560 570 580 590 600
AIQQTYSWTN QIDISDKNGL LVLPKNKKRS RQKTAVHVLN FWCLNPAVAF
610 620 630 640 650
SDINGKVQTI VLTSGTLSPM KSFSSELGVT FTIQLEANHV IKNSQVWVGT
660 670 680 690 700
IGSGPKGRNL CATFQNTETF EFQDEVGALL LSVCQTVSQG ILCFLPSYKL
710 720 730 740 750
LEKLKERWLS TGLWHNLELV KTVIVEPQGG EKTNFDELLQ VYYDAIKYKG
760 770 780 790 800
EKDGALLVAV CRGKVSEGLD FSDDNARAVI TIGIPFPNVK DLQVELKRQY
810 820 830 840 850
NDHHSKLRGL LPGRQWYEIQ AYRALNQALG RCIRHRNDWG ALILVDDRFR
860 870 880 890 900
NNPGRYISGL SKWVRQQIQH HSTFESALES LAEFSKKHQK VLNVSIKDRT
910 920 930 940 950
NIQDNESTLE VTSLKYGTPP YLLEAASHLS PENFVEDEAK MCVQELQCPK
960 970 980 990 1000
IITKNLPLPS GIISRKEKND PVFLEEAGKA EKIVISRSTS PTFNKQTKRV
1010 1020 1030 1040 1050
SWSSFNSLGQ YFTGKIPKAT PELRSSENSA SSPPRFKTEK MESKTVLPFT
1060 1070 1080 1090 1100
DKCESSNLTV NTSFGSCPQS ETIISSLKID ATLSRKNHSE HPLCSEEALD
1110 1120 1130 1140 1150
PDIELSLVSE DQQSTSNRDF ETEAEDESIY FTPELYDPED TDEEKNDLAE
1160 1170 1180 1190 1200
TDRGNRLANN SDCILAKDLF EIRTTKEVDS AREVKAEDCT DTKLNGILHI
1210 1220 1230 1240
EESKIDDIDG NVKTTWINEL ELGKTHEIEI KNFKPSPSKN KGMFPGFK
Length:1,248
Mass (Da):140,776
Last modified:March 21, 2012 - v1
Checksum:i25A3C618BDDB3FB1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ABGA01152142 Genomic DNA No translation available.
ABGA01152143 Genomic DNA No translation available.
ABGA01152144 Genomic DNA No translation available.
ABGA01152145 Genomic DNA No translation available.
ABGA01152146 Genomic DNA No translation available.
ABGA01152147 Genomic DNA No translation available.
ABGA01152148 Genomic DNA No translation available.
ABGA01152149 Genomic DNA No translation available.
ABGA01152150 Genomic DNA No translation available.
ABGA01152151 Genomic DNA No translation available.
NDHI03003397 Genomic DNA Translation: PNJ65688.1

Genome annotation databases

EnsembliENSPPYT00000010276; ENSPPYP00000009883; ENSPPYG00000008802

Similar proteinsi

Entry informationi

Entry nameiH2NV90_PONAB
AccessioniPrimary (citable) accession number: H2NV90
Secondary accession number(s): A0A2J8W7E1
Entry historyiIntegrated into UniProtKB/TrEMBL: March 21, 2012
Last sequence update: March 21, 2012
Last modified: May 23, 2018
This is version 37 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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