UniProtKB - H2NU06 (H2NU06_PONAB)
Protein
Signal transducer and activator of transcription
Gene
STAT3
Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Functioni
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- DNA-binding transcription factor activity Source: InterPro
GO - Biological processi
- signal transduction Source: InterPro
Keywordsi
Molecular function | ActivatorUniRule annotationARBA annotation, DNA-bindingUniRule annotationARBA annotation |
Biological process | Transcription, Transcription regulationUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Signal transducer and activator of transcriptionUniRule annotation |
Gene namesi | Name:STAT3Imported |
Organismi | Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)Imported |
Taxonomic identifieri | 9601 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo |
Proteomesi |
|
Subcellular locationi
Keywords - Cellular componenti
CytoplasmUniRule annotationARBA annotation, NucleusUniRule annotationARBA annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 552 – 642 | SH2InterPro annotationAdd BLAST | 91 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 141 – 168 | Sequence analysisAdd BLAST | 28 | |
Coiled coili | 270 – 290 | Sequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilSequence analysis, SH2 domainPROSITE-ProRule annotationARBA annotationPhylogenomic databases
GeneTreei | ENSGT00990000203570 |
HOGENOMi | CLU_014189_3_0_1 |
Family and domain databases
CDDi | cd10374, SH2_STAT3, 1 hit |
Gene3Di | 1.10.532.10, 1 hit 2.60.40.630, 1 hit 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR008967, p53-like_TF_DNA-bd IPR000980, SH2 IPR036860, SH2_dom_sf IPR001217, STAT IPR035855, STAT3_SH2 IPR036535, STAT_N_sf IPR013800, STAT_TF_alpha IPR015988, STAT_TF_coiled-coil IPR013801, STAT_TF_DNA-bd IPR012345, STAT_TF_DNA-bd_N IPR013799, STAT_TF_prot_interaction |
PANTHERi | PTHR11801, PTHR11801, 2 hits |
Pfami | View protein in Pfam PF00017, SH2, 1 hit PF01017, STAT_alpha, 1 hit PF02864, STAT_bind, 1 hit PF02865, STAT_int, 1 hit |
SMARTi | View protein in SMART SM00964, STAT_int, 1 hit |
SUPFAMi | SSF47655, SSF47655, 1 hit SSF48092, SSF48092, 1 hit SSF49417, SSF49417, 1 hit SSF55550, SSF55550, 1 hit |
PROSITEi | View protein in PROSITE PS50001, SH2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
H2NU06-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAQWNQLQQL DTRYLEQLHQ LYSDSFPMEL RQFLAPWIES QDWAYAASKE
60 70 80 90 100
SHATLVFHNL LGEIDQQYSR FLQESNVLYQ HNLRRIKQFL QSRYLEKPME
110 120 130 140 150
IARIVARCLW EESRLLQTAA TAAQQGGQAN HPTAAVVTEK QQMLEQHLQD
160 170 180 190 200
VRKRVQDLEQ KMKVVENLQD DFDFNYKTLK SQGDMQDLNG NNQSVTRQKM
210 220 230 240 250
QQLEQMLTAL DQMRRSIVSE LAGLLSAMEY VQKTLTDEEL ADWKRRQQIA
260 270 280 290 300
CIGGPPNICL DRLENWITSL AESQLQTRQQ IKKLEELQQK VSYKGDPIVQ
310 320 330 340 350
HRPMLEERIV ELFRNLMKSA FVVERQPCMP MHPDRPLVIK TGVQFTTKVR
360 370 380 390 400
LLVKFPELNY QLKIKVCIDK DSGDVAALRG SRKFNILGTN TKVMNMEESN
410 420 430 440 450
NGSLSAEFKH LTLREQRCGN GGRANCDTHS LPVVVISNIC QMPNAWASIL
460 470 480 490 500
WYNMLTNNPK NVNFFTKPPI GTWDQVAEVL SWQFSSTTKR GLSIEQLTTL
510 520 530 540 550
AEKLLGPGVN YSGCQITWAK FCKENMAGKG FSFWVWLDNI IDLVKKYILA
560 570 580 590 600
LWNEGYIMGF ISKERERAIL STKPPGTFLL RFSESSKEGG VTFTWVEKDI
610 620 630 640 650
SGKTQIQSVE PYTKQQLNNM SFAEIIMGYK IMDATNILVS PLVYLYPDIP
660 670 680 690 700
KEEAFGKYCR PESQEHPEAD PGSAAPYLKT KFICVTPTTC SNTIDLPMSP
710 720 730 740
RTLDSLMQFG NNGEGAEPSA GGQFESLTFD MELTSECATS PM
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketH2NU07 | H2NU07_PONAB | Signal transducer and activator of ... | STAT3 | 772 | Annotation score: |
Genome annotation databases
Ensembli | ENSPPYT00000009815; ENSPPYP00000009436; ENSPPYG00000008392 |
Similar proteinsi
Cross-referencesi
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Genome annotation databases
Ensembli | ENSPPYT00000009815; ENSPPYP00000009436; ENSPPYG00000008392 |
Phylogenomic databases
GeneTreei | ENSGT00990000203570 |
HOGENOMi | CLU_014189_3_0_1 |
Family and domain databases
CDDi | cd10374, SH2_STAT3, 1 hit |
Gene3Di | 1.10.532.10, 1 hit 2.60.40.630, 1 hit 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR008967, p53-like_TF_DNA-bd IPR000980, SH2 IPR036860, SH2_dom_sf IPR001217, STAT IPR035855, STAT3_SH2 IPR036535, STAT_N_sf IPR013800, STAT_TF_alpha IPR015988, STAT_TF_coiled-coil IPR013801, STAT_TF_DNA-bd IPR012345, STAT_TF_DNA-bd_N IPR013799, STAT_TF_prot_interaction |
PANTHERi | PTHR11801, PTHR11801, 2 hits |
Pfami | View protein in Pfam PF00017, SH2, 1 hit PF01017, STAT_alpha, 1 hit PF02864, STAT_bind, 1 hit PF02865, STAT_int, 1 hit |
SMARTi | View protein in SMART SM00964, STAT_int, 1 hit |
SUPFAMi | SSF47655, SSF47655, 1 hit SSF48092, SSF48092, 1 hit SSF49417, SSF49417, 1 hit SSF55550, SSF55550, 1 hit |
PROSITEi | View protein in PROSITE PS50001, SH2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | H2NU06_PONAB | |
Accessioni | H2NU06Primary (citable) accession number: H2NU06 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 21, 2012 |
Last sequence update: | March 21, 2012 | |
Last modified: | February 10, 2021 | |
This is version 47 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |