SMAD3

Functionⁱ

GO - Molecular functionⁱ

bHLH transcription factor binding Source: Ensembl
chromatin DNA binding Source: Ensembl
collagen binding Source: Ensembl
co-SMAD binding Source: Ensembl
DEAD/H-box RNA helicase binding Source: Ensembl
DNA-binding transcription activator activity, RNA polymerase II-specific Source: Ensembl
glucocorticoid receptor binding Source: Ensembl
mineralocorticoid receptor binding Source: Ensembl
phosphatase binding Source: Ensembl
protein homodimerization activity Source: Ensembl
protein kinase binding Source: Ensembl
RNA polymerase II activating transcription factor binding Source: Ensembl
RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: Ensembl
R-SMAD binding Source: Ensembl
transcription coactivator binding Source: Ensembl
transforming growth factor beta receptor binding Source: Ensembl
ubiquitin binding Source: Ensembl
ubiquitin protein ligase binding Source: Ensembl
zinc ion binding Source: Ensembl

GO - Biological processⁱ

activation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
cell-cell junction organization Source: Ensembl
cell cycle arrest Source: Ensembl
developmental growth Source: Ensembl
embryonic cranial skeleton morphogenesis Source: Ensembl
embryonic foregut morphogenesis Source: Ensembl
embryonic pattern specification Source: Ensembl
endoderm development Source: Ensembl
extrinsic apoptotic signaling pathway Source: Ensembl
heart looping Source: Ensembl
immune response Source: Ensembl
immune system development Source: Ensembl
in utero embryonic development Source: Ensembl
lens fiber cell differentiation Source: Ensembl
liver development Source: Ensembl
mesoderm formation Source: Ensembl
negative regulation of cell growth Source: Ensembl
negative regulation of cytosolic calcium ion concentration Source: Ensembl
negative regulation of fat cell differentiation Source: Ensembl
negative regulation of inflammatory response Source: Ensembl
negative regulation of mitotic cell cycle Source: Ensembl
negative regulation of osteoblast differentiation Source: Ensembl
negative regulation of osteoblast proliferation Source: Ensembl
negative regulation of transcription by RNA polymerase II Source: Ensembl
negative regulation of wound healing Source: Ensembl
nodal signaling pathway Source: Ensembl
osteoblast development Source: Ensembl
paraxial mesoderm morphogenesis Source: Ensembl
pericardium development Source: Ensembl
positive regulation of chondrocyte differentiation Source: Ensembl
positive regulation of epithelial to mesenchymal transition Source: Ensembl
positive regulation of extracellular matrix assembly Source: Ensembl
positive regulation of nitric oxide biosynthetic process Source: Ensembl
positive regulation of pri-miRNA transcription by RNA polymerase II Source: Ensembl
regulation of binding Source: Ensembl
regulation of epithelial cell proliferation Source: Ensembl
regulation of immune response Source: Ensembl
regulation of striated muscle tissue development Source: Ensembl
regulation of transforming growth factor beta2 production Source: Ensembl
regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
response to hypoxia Source: Ensembl
SMAD protein complex assembly Source: Ensembl
SMAD protein signal transduction Source: Ensembl
somitogenesis Source: Ensembl
T cell activation Source: Ensembl
thyroid gland development Source: Ensembl
transforming growth factor beta receptor signaling pathway Source: Ensembl
ureteric bud development Source: Ensembl

Keywordsⁱ

Molecular function	DNA-bindingUniRule annotationARBA annotation
Biological process	Transcription, Transcription regulationUniRule annotationARBA annotation
Ligand	Metal-bindingARBA annotation, ZincARBA annotation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Mothers against decapentaplegic homologUniRule annotation Short name: MAD homologUniRule annotation Short name: Mothers against DPP homologUniRule annotation Alternative name(s): SMAD family memberUniRule annotation
Gene namesⁱ	Name:SMAD3Imported
Organismⁱ	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)Imported
Taxonomic identifierⁱ	9601 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Ponginae › Pongo
Proteomesⁱ	UP000001595 Componentⁱ: Chromosome 15

Keywords - Cellular componentⁱ

CytoplasmUniRule annotation, NucleusUniRule annotationARBA annotation

Interactionⁱ

GO - Molecular functionⁱ

bHLH transcription factor binding Source: Ensembl
co-SMAD binding Source: Ensembl
DEAD/H-box RNA helicase binding Source: Ensembl
glucocorticoid receptor binding Source: Ensembl
mineralocorticoid receptor binding Source: Ensembl
phosphatase binding Source: Ensembl
protein homodimerization activity Source: Ensembl
protein kinase binding Source: Ensembl
RNA polymerase II activating transcription factor binding Source: Ensembl
R-SMAD binding Source: Ensembl
transcription coactivator binding Source: Ensembl
transforming growth factor beta receptor binding Source: Ensembl
ubiquitin binding Source: Ensembl
ubiquitin protein ligase binding Source: Ensembl

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	9601.ENSPPYP00000007465

STRINGⁱ

9601.ENSPPYP00000007465

Structureⁱ

3D structure databases

SMRⁱ	H2NNK3
ModBaseⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the dwarfin/SMAD family.UniRule annotationARBA annotation

Phylogenomic databases

eggNOGⁱ	KOG3701, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000153499
HOGENOMⁱ	CLU_026736_0_0_1
InParanoidⁱ	H2NNK3
OMAⁱ	NPVSPAH
Database of Orthologous Groups More...OrthoDBⁱ	608001at2759
TreeFamⁱ	TF314923

Family and domain databases

Gene3Dⁱ	2.60.200.10, 1 hit 3.90.520.10, 1 hit
InterProⁱ	View protein in InterPro IPR013790, Dwarfin IPR003619, MAD_homology1_Dwarfin-type IPR013019, MAD_homology_MH1 IPR017855, SMAD-like_dom_sf IPR001132, SMAD_dom_Dwarfin-type IPR008984, SMAD_FHA_dom_sf IPR036578, SMAD_MH1_sf
PANTHERⁱ	PTHR13703, PTHR13703, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03165, MH1, 1 hit PF03166, MH2, 1 hit
SMARTⁱ	View protein in SMART SM00523, DWA, 1 hit SM00524, DWB, 1 hit
SUPFAMⁱ	SSF49879, SSF49879, 1 hit SSF56366, SSF56366, 1 hit
PROSITEⁱ	View protein in PROSITE PS51075, MH1, 1 hit PS51076, MH2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

H2NNK3-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSSILPFTPP IVKRLLGWKK GEQNGQEEKW CEKAVKSLVK KLKKTGQLDE 
        60         70         80         90        100
LEKAITTQNV NTKCITIPRS LDGRLQVSHR KGLPHVIYCR LWRWPDLHSH 
       110        120        130        140        150
HELRAMELCE FAFNMKKDEV CVNPYHYQRV ETPVLPPVLV PRHTEIPAEF 
       160        170        180        190        200
PPLDDYSHSI PENTNFPAGI EPQSNIPETP PPGYLSEDGE TSDHQMNHSM 
       210        220        230        240        250
DAGSPNLSPN PMSPAHNNLD LQPVTYCEPA FWCSISYYEL NQRVGETFHA 
       260        270        280        290        300
SQPSMTVDGF TDPSNSERFC LGLLSNVNRN AAVELTRRHI GRGVRLYYIG 
       310        320        330        340        350
GEVFAECLSD SAIFVQSPNC NQRYGWHPAT VCKIPPGCNL KIFNNQEFAA 
       360        370        380        390        400
LLAQSVNQGF EAVYQLTRMC TIRMSFVKGW GAEYRRQTVT STPCWIELHL 
       410        420 
NGPLQWLDKV LTQMGSPSIR CSSVS

Length:425

Mass (Da):48,081

Last modified:March 21, 2012 - v1

Checksum:ⁱ46DF5E8B371321AC

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC190145 Genomic DNA No translation available.
NCBI Reference Sequences More...RefSeqⁱ	XP_002825631.1, XM_002825585.3

Genome annotation databases

Ensemblⁱ	ENSPPYT00000007769; ENSPPYP00000007465; ENSPPYG00000006583
GeneIDⁱ	100448249
KEGGⁱ	pon:100448249

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
H2NNK3	Mothers against decapentaplegic homolog 3	)	HUMAN		425	UniRef100_P84022
Mothers against decapentaplegic homolog 3		MOUSE		425
Mothers against decapentaplegic homolog 3		PIG		425
Mothers against decapentaplegic homolog 3		RAT		425
Mothers against decapentaplegic homolog		GORGO		356
+79

Protein	Similar proteins		Species	Score	Length	Source
H2NNK3	Mothers against decapentaplegic homolog 3	)	HUMAN		425	UniRef90_P84022
Mothers against decapentaplegic homolog 3		MOUSE		425
Mothers against decapentaplegic homolog 3		PIG		425
Mothers against decapentaplegic homolog 3		RAT		425
Mothers against decapentaplegic homolog		GORGO		356
+82

Protein	Similar proteins		Species	Score	Length	Source
H2NNK3	Mothers against decapentaplegic homolog 3	)	HUMAN		425	UniRef50_P84022
Mothers against decapentaplegic homolog 3		MOUSE		425
Mothers against decapentaplegic homolog 3		PIG		425
Mothers against decapentaplegic homolog 3		RAT		425
Mothers against decapentaplegic homolog		GORGO		356
+135

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC190145 Genomic DNA No translation available.
RefSeqⁱ	XP_002825631.1, XM_002825585.3

3D structure databases

SMRⁱ	H2NNK3
ModBaseⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9601.ENSPPYP00000007465

STRINGⁱ

9601.ENSPPYP00000007465

Genome annotation databases

Ensemblⁱ	ENSPPYT00000007769; ENSPPYP00000007465; ENSPPYG00000006583
GeneIDⁱ	100448249
KEGGⁱ	pon:100448249

Organism-specific databases

CTDⁱ	4088

CTDⁱ

4088

Phylogenomic databases

eggNOGⁱ	KOG3701, Eukaryota
GeneTreeⁱ	ENSGT00940000153499
HOGENOMⁱ	CLU_026736_0_0_1
InParanoidⁱ	H2NNK3
OMAⁱ	NPVSPAH
OrthoDBⁱ	608001at2759
TreeFamⁱ	TF314923

Family and domain databases

Gene3Dⁱ	2.60.200.10, 1 hit 3.90.520.10, 1 hit
InterProⁱ	View protein in InterPro IPR013790, Dwarfin IPR003619, MAD_homology1_Dwarfin-type IPR013019, MAD_homology_MH1 IPR017855, SMAD-like_dom_sf IPR001132, SMAD_dom_Dwarfin-type IPR008984, SMAD_FHA_dom_sf IPR036578, SMAD_MH1_sf
PANTHERⁱ	PTHR13703, PTHR13703, 1 hit
Pfamⁱ	View protein in Pfam PF03165, MH1, 1 hit PF03166, MH2, 1 hit
SMARTⁱ	View protein in SMART SM00523, DWA, 1 hit SM00524, DWB, 1 hit
SUPFAMⁱ	SSF49879, SSF49879, 1 hit SSF56366, SSF56366, 1 hit
PROSITEⁱ	View protein in PROSITE PS51075, MH1, 1 hit PS51076, MH2, 1 hit
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	H2NNK3_PONAB
Accessionⁱ	H2NNK3Primary (citable) accession number: H2NNK3 Secondary accession number(s): A0A2J8UC54
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	March 21, 2012
	Last sequence update:	March 21, 2012
	Last modified:	December 2, 2020
	This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Reference proteomeImported

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - H2NNK3 (H2NNK3_PONAB)

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Mothers against decapentaplegic homolog

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

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Cytosol

Nucleus

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ