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UniProtKB - H2NLR2 (H2NLR2_PONAB)

Entry version 48 (07 Oct 2020)
Sequence version 2 (09 Jan 2013)
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Protein
Submitted name:

ELM2 and Myb/SANT domain containing 1

Gene

MIDEAS

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
ELM2 and Myb/SANT domain containing 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MIDEASImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9601 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001595 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

NucleusARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		9601.ENSPPYP00000006792

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini642 – 734ELM2InterPro annotationAdd BLAST93
Domaini749 – 800SANTInterPro annotationAdd BLAST52
Domaini959 – 986C2H2-typeInterPro annotationAdd BLAST28

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 69DisorderedSequence analysisAdd BLAST69
Regioni99 – 159DisorderedSequence analysisAdd BLAST61
Regioni228 – 264DisorderedSequence analysisAdd BLAST37
Regioni278 – 304DisorderedSequence analysisAdd BLAST27
Regioni343 – 397DisorderedSequence analysisAdd BLAST55
Regioni808 – 957DisorderedSequence analysisAdd BLAST150
Regioni996 – 1022DisorderedSequence analysisAdd BLAST27

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi116 – 142PolarSequence analysisAdd BLAST27
Compositional biasi244 – 264PolarSequence analysisAdd BLAST21
Compositional biasi815 – 830PolyampholyteSequence analysisAdd BLAST16
Compositional biasi840 – 887PolyampholyteSequence analysisAdd BLAST48
Compositional biasi889 – 907PolarSequence analysisAdd BLAST19
Compositional biasi927 – 950PolyampholyteSequence analysisAdd BLAST24

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4167, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157459

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_011395_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		H2NLR2

Identification of Orthologs from Complete Genome Data

More...OMAi		FHVAKKP

TreeFam database of animal gene trees

More...TreeFami		TF106431

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000949, ELM2_dom
IPR009057, Homeobox-like_sf
IPR001005, SANT/Myb
IPR017884, SANT_dom
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01448, ELM2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01189, ELM2, 1 hit
SM00717, SANT, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF46689, SSF46689, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51156, ELM2, 1 hit
PS51293, SANT, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 1 hit
PS50157, ZINC_FINGER_C2H2_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

H2NLR2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNLQAQPKAQ NKRKRCLFGG QEPAPKEQPP PLQPPQQSIR VKEEQYVGHE 
        60         70         80         90        100
GPGGAVSTSQ PVELPPPSSL ALLNSVVYGP ERTSAAMLSQ QVASVKWPNS 
       110        120        130        140        150
VMAPGRGPER GGGGGVSDSS WQQQPGQPPP HSTWNCHSLS LYSAPKGSPH 
       160        170        180        190        200
PGVGVPTYYN HPEALKREKA GGPQLDRYVR PMMPQKMQLE VGRPQAPLNS 
       210        220        230        240        250
FHAAKKPPNQ SLPLQPFQLA FGHQVNRQVF RQGPPPPNPV AAFPPQKQQQ 
       260        270        280        290        300
QQQPQQQQQQ QQAALPQMPL FENFYSMSQQ PSQQPQDFGL QPAGPLGQSH 
       310        320        330        340        350
LAHHSMAPYP FPSNPDMNPE LRKALLQESA PQPALPQVQI PFPRRSRRLS 
       360        370        380        390        400
KEGILPPTAL DGAGTQPGQE PTGNLFLHHW PLQQPPPGSL GQPHPEALGF 
       410        420        430        440        450
PLELRESQLL PDGERLAPNG REREAPAMGN EEGMRAVSTG DCGQVLRGGV 
       460        470        480        490        500
IQSTRRRRRA SQEANLLTLA QKAVELASLQ NAKDGSGSEE KRKSVLASTT 
       510        520        530        540        550
KCGVEFSEPS LATKRAREDS GMIPLIIPVS VPVRTVDPTE AAQAGGLDED 
       560        570        580        590        600
GKGPEQNPAE HKPSVIVTRR RSTRIPGTDA PAQVREGFGF YFNAIISTST 
       610        620        630        640        650
IPAPPPITPK SVHCMLLRTN SAEVTPPVLS VMGEATPVSI EPRINVGSRF 
       660        670        680        690        700
QAEIPLMRDR ALAAADPHKA DLVWQPWEDL ESSREKQRQV EDLLTAACSS 
       710        720        730        740        750
IFPGAGTNQE LALHCLHESR GDILETLNKL LLKKPLRPHN HPLATYHYTG 
       760        770        780        790        800
SDQWKMAERK LFNKGIAIYK KDFFLVQKLI QTKTVAQCVE FYYTYKKQVK 
       810        820        830        840        850
IGRNGTLTFG DVDTSDEKSA QEDVEVDIKT SQKFPRVPLP RRESPSEERL 
       860        870        880        890        900
EPKREVKESR KEGEEEVPEI QEKEEQEEGR ERSRRAAAVK ATQTLQANES 
       910        920        930        940        950
ASDILILRSH ESNAPGSAGG QASEKPREGT GKSRRALPFS EKKKKTETFS 
       960        970        980        990       1000
KTQNQENTFP CKKCGRVFYK VKSRSAHMKS HAEQEKKAAA LRLKEKEAAA 
      1010       1020 
AAAAAHQQAL REESGVGAGD KG
Length:1,022
Mass (Da):112,190
Last modified:January 9, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE0848DFF59435013
GO

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSPPYT00000007060; ENSPPYP00000006792; ENSPPYG00000005975

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000006792

Genome annotation databases

EnsembliENSPPYT00000007060; ENSPPYP00000006792; ENSPPYG00000005975

Phylogenomic databases

eggNOGiKOG4167, Eukaryota
GeneTreeiENSGT00940000157459
HOGENOMiCLU_011395_0_0_1
InParanoidiH2NLR2
OMAiFHVAKKP
TreeFamiTF106431

Family and domain databases

InterProiView protein in InterPro
IPR000949, ELM2_dom
IPR009057, Homeobox-like_sf
IPR001005, SANT/Myb
IPR017884, SANT_dom
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF01448, ELM2, 1 hit
SMARTiView protein in SMART
SM01189, ELM2, 1 hit
SM00717, SANT, 1 hit
SUPFAMiSSF46689, SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS51156, ELM2, 1 hit
PS51293, SANT, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 1 hit
PS50157, ZINC_FINGER_C2H2_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH2NLR2_PONAB
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H2NLR2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 21, 2012
Last sequence update: January 9, 2013
Last modified: October 7, 2020
This is version 48 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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