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Entry version 55 (07 Oct 2020)
Sequence version 1 (21 Mar 2012)
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Protein
Submitted name:

Uncharacterized protein

Gene

MRC1

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptorARBA annotation
Biological processEndocytosisARBA annotation
LigandLectinARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MRC1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9601 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001595 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1387 – 1410HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500356718320 – 1455Sequence analysisAdd BLAST1436

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi168 ↔ 194PROSITE-ProRule annotation
Disulfide bondi182 ↔ 209PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9601.ENSPPYP00000002469

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini22 – 142Ricin B-type lectinInterPro annotationAdd BLAST121
Domaini163 – 211Fibronectin type-IIInterPro annotationAdd BLAST49
Domaini225 – 340C-type lectinInterPro annotationAdd BLAST116
Domaini368 – 486C-type lectinInterPro annotationAdd BLAST119
Domaini510 – 625C-type lectinInterPro annotationAdd BLAST116
Domaini654 – 777C-type lectinInterPro annotationAdd BLAST124
Domaini806 – 922C-type lectinInterPro annotationAdd BLAST117
Domaini951 – 1079C-type lectinInterPro annotationAdd BLAST129
Domaini1101 – 1212C-type lectinInterPro annotationAdd BLAST112
Domaini1240 – 1355C-type lectinInterPro annotationAdd BLAST116

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4297, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT01000000214487

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002069_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
H2N9W2

Identification of Orthologs from Complete Genome Data

More...
OMAi
PYAGNCY

TreeFam database of animal gene trees

More...
TreeFami
TF316663

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00062, FN2, 1 hit
cd00161, RICIN, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.10.10.10, 1 hit
3.10.100.10, 8 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001304, C-type_lectin-like
IPR016186, C-type_lectin-like/link_sf
IPR018378, C-type_lectin_CS
IPR016187, CTDL_fold
IPR000562, FN_type2_dom
IPR036943, FN_type2_sf
IPR035992, Ricin_B-like_lectins
IPR000772, Ricin_B_lectin

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00040, fn2, 1 hit
PF00059, Lectin_C, 8 hits
PF00652, Ricin_B_lectin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00034, CLECT, 8 hits
SM00059, FN2, 1 hit
SM00458, RICIN, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50370, SSF50370, 1 hit
SSF56436, SSF56436, 8 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00615, C_TYPE_LECTIN_1, 6 hits
PS50041, C_TYPE_LECTIN_2, 8 hits
PS00023, FN2_1, 1 hit
PS51092, FN2_2, 1 hit
PS50231, RICIN_B_LECTIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

H2N9W2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRLPLLLVFA SVIPGAVLLL DTRQFLIYNE DHKRCVDAIS PSAVQTAACN
60 70 80 90 100
QDAESQKFRW VSESQIMSVA FKLCLGVPSK TDWVAITLYA CDSKSEFQKW
110 120 130 140 150
ECKNDTLLGI KGEDLFFNYG NRQEKNIMLY KGISLWSRWK IYGTTDNLCS
160 170 180 190 200
RGYEAMYTLL GNANGATCAF PFKFENKWYA DCTSAGRSDG WLWCGTTTDY
210 220 230 240 250
DTDKLFGYCP LKFEGSESLW NKDPLTSISY QINSKSALTW HQARKSCQQQ
260 270 280 290 300
NAELLSITEI HEQTYLTGLT SSLTSGLWIG LNSLSFNSGW QWSDRSPFRY
310 320 330 340 350
LNWLPGSPSA EPGKSCVSLN PGKNAWENLE CVQKLGYVCK KGNTTLNSFV
360 370 380 390 400
IPSESDVPTH CPSQWWPYAG HCYKIHRDEK KIQRDALTAC RKEGGDLASI
410 420 430 440 450
HTIEEFDFII SQLGYEPNDE LWIGLNDIKI QMYFEWSDGT PVTFTKWLRG
460 470 480 490 500
EPSHENNRQE DCVVMKGKDG YWADRGCEWP LGYICKMKSQ SQGPEIVEVE
510 520 530 540 550
KGCRKGWKKH HFYCYMIGHT LSTFAEANQT CNNENAYLTT IEDRYEQAFL
560 570 580 590 600
TSFVGLRPEK YFWTGLSDIQ TKGTFQWTIE EEVRFTHWNS DMPGRKPGCV
610 620 630 640 650
AMRTGIAGGL WDVLKCDEKA KFVCKHWAEG VTHPPKPTTT PEPKCPEDWG
660 670 680 690 700
ASSRTSLCFK LYAKGKHEKK TWFESRDFCR ALGGDLASIN NKEEQQTIWR
710 720 730 740 750
LITASGSYHE LFWLGLTYGS PSEGFTWSDG SPVSYENWAY GEPNNYQNVE
760 770 780 790 800
YCGELKGDPT MSWNDINCEH LNNWICQIQK GQTPKPEPTP APQDNPPVTE
810 820 830 840 850
DGWVIYKDYQ YYFSKEKETM DNARAFCKRS FGDLVSIQSE SEKKFLWKYV
860 870 880 890 900
NRNDAQSAYF IGLLISLDKK FAWMDGSKVD YVSWATGEPN FANEDENCVT
910 920 930 940 950
MYSNSGFWND INCGYPNAFI CQRHNSSINA TTVMPTTPSV PSGCKEGWNF
960 970 980 990 1000
YNNKCFKIFG FMEEERKNWQ EARKACIGFG GNLVSIQNEK EQAFLTYHMK
1010 1020 1030 1040 1050
DSTFSAWTGL NDVNSEHTFL WTDGRGVHYT NWGKGYPGGR RSSLSYEDAD
1060 1070 1080 1090 1100
CVVIIGGTSN EAGKWMDDTC DSKRGYICQT RSDPSLTNPP ATIQTDGFIK
1110 1120 1130 1140 1150
YGKSSYSLMR QKFQWHEAET YCKLHNSLIA SILDPYSNAF AWLQMETSNE
1160 1170 1180 1190 1200
RVWIALNSNL TDNQYTWTDK WRVRYTNWAA DEPKLKSACV YLDLDGYWKT
1210 1220 1230 1240 1250
AHCNESFYFL CKRSDEIPAT EPPQLPGRCP ESDHTAWIPF HGHCYYIESS
1260 1270 1280 1290 1300
YTRNWGQASL ECLRMGSSLV SIESAAEFSF LSYRVEPLKS KTNFWIGLFR
1310 1320 1330 1340 1350
NVEGTWLWIN NSPVSFVNWN TGDPSGERND CVALHASSGF WSNIHCSSYK
1360 1370 1380 1390 1400
GYICKRPKII DAEPTQELLT TKADTRKMDP SKPSSNVAGV VIIVILLILT
1410 1420 1430 1440 1450
GAGLAAYFFY KKRRVHLPQE GAFENTLYFN SQSSPGTSDM KDLVGNIEQN

EHAVI
Length:1,455
Mass (Da):165,950
Last modified:March 21, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i055EA8A042D02D1A
GO

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSPPYT00000002544; ENSPPYP00000002469; ENSPPYG00000002128

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000002469

Genome annotation databases

EnsembliENSPPYT00000002544; ENSPPYP00000002469; ENSPPYG00000002128

Phylogenomic databases

eggNOGiKOG4297, Eukaryota
GeneTreeiENSGT01000000214487
HOGENOMiCLU_002069_0_0_1
InParanoidiH2N9W2
OMAiPYAGNCY
TreeFamiTF316663

Family and domain databases

CDDicd00062, FN2, 1 hit
cd00161, RICIN, 1 hit
Gene3Di2.10.10.10, 1 hit
3.10.100.10, 8 hits
InterProiView protein in InterPro
IPR001304, C-type_lectin-like
IPR016186, C-type_lectin-like/link_sf
IPR018378, C-type_lectin_CS
IPR016187, CTDL_fold
IPR000562, FN_type2_dom
IPR036943, FN_type2_sf
IPR035992, Ricin_B-like_lectins
IPR000772, Ricin_B_lectin
PfamiView protein in Pfam
PF00040, fn2, 1 hit
PF00059, Lectin_C, 8 hits
PF00652, Ricin_B_lectin, 1 hit
SMARTiView protein in SMART
SM00034, CLECT, 8 hits
SM00059, FN2, 1 hit
SM00458, RICIN, 1 hit
SUPFAMiSSF50370, SSF50370, 1 hit
SSF56436, SSF56436, 8 hits
PROSITEiView protein in PROSITE
PS00615, C_TYPE_LECTIN_1, 6 hits
PS50041, C_TYPE_LECTIN_2, 8 hits
PS00023, FN2_1, 1 hit
PS51092, FN2_2, 1 hit
PS50231, RICIN_B_LECTIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH2N9W2_PONAB
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H2N9W2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 21, 2012
Last sequence update: March 21, 2012
Last modified: October 7, 2020
This is version 55 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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