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Entry version 50 (02 Jun 2021)
Sequence version 2 (05 Dec 2018)
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Protein
Submitted name:

Uncharacterized protein

Gene

hivep2

Organism
Oryzias latipes (Japanese rice fish) (Japanese killifish)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:hivep2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiOryzias latipes (Japanese rice fish) (Japanese killifish)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaAtherinomorphaeBeloniformesAdrianichthyidaeOryziinaeOryzias
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001038 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 24

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
8090.ENSORLP00000022708

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini204 – 231C2H2-typeInterPro annotationAdd BLAST28
Domaini232 – 255C2H2-typeInterPro annotationAdd BLAST24
Domaini1726 – 1753C2H2-typeInterPro annotationAdd BLAST28
Domaini1754 – 1778C2H2-typeInterPro annotationAdd BLAST25

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 120DisorderedSequence analysisAdd BLAST120
Regioni145 – 201DisorderedSequence analysisAdd BLAST57
Regioni275 – 305DisorderedSequence analysisAdd BLAST31
Regioni379 – 435DisorderedSequence analysisAdd BLAST57
Regioni506 – 540DisorderedSequence analysisAdd BLAST35
Regioni577 – 608DisorderedSequence analysisAdd BLAST32
Regioni643 – 672DisorderedSequence analysisAdd BLAST30
Regioni685 – 705DisorderedSequence analysisAdd BLAST21
Regioni742 – 1006DisorderedSequence analysisAdd BLAST265
Regioni1113 – 1132DisorderedSequence analysisAdd BLAST20
Regioni1171 – 1200DisorderedSequence analysisAdd BLAST30
Regioni1408 – 1454DisorderedSequence analysisAdd BLAST47
Regioni1490 – 1527DisorderedSequence analysisAdd BLAST38
Regioni1792 – 1865DisorderedSequence analysisAdd BLAST74
Regioni1918 – 2062DisorderedSequence analysisAdd BLAST145
Regioni2196 – 2242DisorderedSequence analysisAdd BLAST47
Regioni2290 – 2352DisorderedSequence analysisAdd BLAST63

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 27Basic and acidic residuesSequence analysisAdd BLAST27
Compositional biasi63 – 77Polar residuesSequence analysisAdd BLAST15
Compositional biasi168 – 182Polar residuesSequence analysisAdd BLAST15
Compositional biasi391 – 411Basic and acidic residuesSequence analysisAdd BLAST21
Compositional biasi412 – 435Polar residuesSequence analysisAdd BLAST24
Compositional biasi520 – 540Polar residuesSequence analysisAdd BLAST21
Compositional biasi589 – 605Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi643 – 661Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi688 – 705Polar residuesSequence analysisAdd BLAST18
Compositional biasi742 – 784Polar residuesSequence analysisAdd BLAST43
Compositional biasi794 – 820Polar residuesSequence analysisAdd BLAST27
Compositional biasi839 – 864Basic and acidic residuesSequence analysisAdd BLAST26
Compositional biasi902 – 935Polar residuesSequence analysisAdd BLAST34
Compositional biasi945 – 973Polar residuesSequence analysisAdd BLAST29
Compositional biasi1511 – 1526Polar residuesSequence analysisAdd BLAST16
Compositional biasi1806 – 1826Basic and acidic residuesSequence analysisAdd BLAST21
Compositional biasi1827 – 1851Acidic residuesSequence analysisAdd BLAST25
Compositional biasi1956 – 1970Polar residuesSequence analysisAdd BLAST15
Compositional biasi2047 – 2062Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi2293 – 2315Polar residuesSequence analysisAdd BLAST23
Compositional biasi2333 – 2352Polar residuesSequence analysisAdd BLAST20

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156512

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000719_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
H2MV82

Database of Orthologous Groups

More...
OrthoDBi
212048at2759

TreeFam database of animal gene trees

More...
TreeFami
TF331837

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00096, zf-C2H2, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00355, ZnF_C2H2, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57667, SSF57667, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 3 hits
PS50157, ZINC_FINGER_C2H2_2, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

H2MV82-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDPHDSTVTR QKGSNRDEVK EKIPLQRKWA SEPSANTKQN TFCDPEVKHR
60 70 80 90 100
ESLPCGAMRG STPQQKYPMT GNPVQLLSGP SGVGAIGGPP SADPQGPLTQ
110 120 130 140 150
GFPRGYPYQL GQPYPQHPQT ERFISGAKPQ PGLESHAWPF AGQLPSDDPY
160 170 180 190 200
GHPGHTHLHK AGRFPRQKSP SLPSSFGQYS QSGLEPGEEG YSKKEQKPKK
210 220 230 240 250
PGKYICHYCG RACAKPSVLK KHIRSHTGER PYPCEPCGFS FKTKSNLYKH
260 270 280 290 300
RKSHAHAIKA GLVPFSSELA VTHSEDVGQA SPVGEGEAPS DGEQSTDTDE
310 320 330 340 350
EGVEGSTMLM EKHSPIPQIS FEANKTAGGG EPAYADSAEE FHIGSMKVPI
360 370 380 390 400
LIFPKPGVVP PGGMDCPTFH DAKVSHHMLA SQAGGRSHSL DDSSSSKRLA
410 420 430 440 450
QRMDEKKVQD SDPSISQSLN LLSPHSKGST DSGYFSPYDS AELQIGTPNT
460 470 480 490 500
SAKTYEEIMF GRTWYNRPNS RPRQSMTVGM AAADGNGSLK QQDLDMCKIA
510 520 530 540 550
EDPSSFKESL GMSGDAKKYP TGPCQSSTGL LEPPSESGTL IRSRSMPAPV
560 570 580 590 600
PSNLNTPQGI RGSISFDNMV PADDVFYPPG QPKLKRQSAF EHPANESHPG
610 620 630 640 650
EAEGHPHMAK GLASSVGLKI TERCPGGPED IFYNQHPSRV SISEIATRKR
660 670 680 690 700
RKEKSVGDDE DSPENCDSSF SSSVDIIGDY DFKQGSFDGS RGTPTGKSSF
710 720 730 740 750
HSTHSQSDSF DTCVSMCSDD IVPFPDSEGR KPAGNVISVI QHTNSLSRPN
760 770 780 790 800
SFEKSESFEQ PVHQPSDKAP SSQYSEQSDT DIYEDALSPE SALQRAESME
810 820 830 840 850
QQQSDSDLAS FSSSSAAASP GQPYHKLVRQ PNIQVPEIRV TEEPDKPEKD
860 870 880 890 900
TEPLVTKEPE KQPPAVEEFQ LPQRSDTLSQ MPTEKLPPKK KRLRLADMEY
910 920 930 940 950
SSGESSFEST CTSLSRSPSQ ESNLSHSSSM SMSFEKDEGV KSVSPTKQED
960 970 980 990 1000
SLANGSGAKQ SEFLTVPSSF SSHHQQREMR RSSSEQAPCT LPTELPEMRS
1010 1020 1030 1040 1050
KSFDYGSLPS CRQGEVYTST SAKKERRRGY LVRQASLSVY PEGVLQDIGG
1060 1070 1080 1090 1100
GQVSIKQENL EHGVWPIPSG SPHSSSEMAI RTRRPVVGSH QQPPQHVFRQ
1110 1120 1130 1140 1150
SISDDSLQDE PCFGRPKQHR LQAQGSSSEG EHPVLEVRNR DLIQQYQGGV
1160 1170 1180 1190 1200
PFAPFSQPCA FWNQEAEKAA RQQQQLQKLH LRSPSSLPGP AAPKQSAQQV
1210 1220 1230 1240 1250
YDPQLYEGKT EHQSTHIYSP SFPSHINMLS PANSVLQRHL QPTQNLSSKT
1260 1270 1280 1290 1300
TSPGLVVPVR IQTYVPVFGS ATYTSVSQFM SCHANEADAL GADRCENSTL
1310 1320 1330 1340 1350
GGVRPCNPPG GISRSGFNLS LLLGHTDSDL LRSSFWKGSE KHLNTGIPLS
1360 1370 1380 1390 1400
LTSGTISTTD ASGSAIGGGK RMLSPTSSLE LFIQSKQQKR VKEERMYGQI
1410 1420 1430 1440 1450
VKEMSAVELS GAERGTTPEK QGGSNQRAPL RSKDSVDECE RMSSSPPLSD
1460 1470 1480 1490 1500
PPAATKIAVP VRSSAPHLSD VPQGDSFPPP LQIVTERGLV SCSQDSPERL
1510 1520 1530 1540 1550
DVDDVSPGPS SSPEPMLSSS DAESSDKQAL LLKPAPTHSS GMTGGAQSLL
1560 1570 1580 1590 1600
FTNLSEVQQL LHFPSLRTTS RVSWCFRNYT KPNSTQAASH CSVYSSWSVS
1610 1620 1630 1640 1650
THNPNPLNIS TKAALALLRS KQRENTEWLF TLAAMCPPSS GKLVSSVAWK
1660 1670 1680 1690 1700
LMFDQLKPDL GPADLNCFGR KMKGVESWER SKVELGEKVA SAKQLSTEPT
1710 1720 1730 1740 1750
RIKIFEGGYK SNEDYVYVRG RGRGKYICEE CGIRCKKPSM LKKHIRTHTD
1760 1770 1780 1790 1800
VRPYVCKFCN FAFKTKGNLT KHMKSKAHIK KCLELGVSMS SVEDTEAEEG
1810 1820 1830 1840 1850
DVPEDDGGSS EKTSRQRSVE HQFSDADDSD GAEDDGDEVE DEDDEEDDYD
1860 1870 1880 1890 1900
GDSTPKTGSR SCSPQLYALP PMSIAHVATL NPAPHLLHPT ATDLLGTPPR
1910 1920 1930 1940 1950
PPLLGYFTTV PSIQITPQAQ PSDAAGRERL QAEDPGCQLQ PLGSRLLALP
1960 1970 1980 1990 2000
SSSMDEDLPD LSSPSSRLSS PGLEPPGCPS PISPSSSPST HRYLSPCRNL
2010 2020 2030 2040 2050
SPSARHLSPR RDISPLRHIS TAGGYRRDLS PRRRHAVVSP LSRPLSPRGR
2060 2070 2080 2090 2100
DYKRDLSPQG QHKRMIRHVS PCRGPLHQSQ QGVVWGPRST ARLQAELPVG
2110 2120 2130 2140 2150
TLQTCAEMET NHPSGSLLHG EQDHRSNQNN LSSAPLQVLF SHLPLHSQFP
2160 2170 2180 2190 2200
MPSSLPLIPI GGIHMVNFAP TPIGSCLDQQ GGASAVSHLT LQKSTSEDSN
2210 2220 2230 2240 2250
CGEANFPHFS SISKRRGPAE GQGAREASSP QQREGGGVRL EQEEGIQTCT
2260 2270 2280 2290 2300
QAIASLCIDS GVRRAMGNEG KGGSASPSFS PFPPPSLTIG CISSLIPHPS
2310 2320 2330 2340 2350
QSPQNPGNQH LSSQELRPIP PIAPPSAHVP HSPGSDPQLS PSASKPANPE

SD
Length:2,352
Mass (Da):254,951
Last modified:December 5, 2018 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i444C19E273B1C399
GO

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_011490407.1, XM_011492105.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSORLT00000022709; ENSORLP00000022708; ENSORLG00000018133
ENSORLT00000040098; ENSORLP00000040727; ENSORLG00000018133

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_011490407.1, XM_011492105.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi8090.ENSORLP00000022708

Genome annotation databases

EnsembliENSORLT00000022709; ENSORLP00000022708; ENSORLG00000018133
ENSORLT00000040098; ENSORLP00000040727; ENSORLG00000018133

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00940000156512
HOGENOMiCLU_000719_0_0_1
InParanoidiH2MV82
OrthoDBi212048at2759
TreeFamiTF331837

Family and domain databases

InterProiView protein in InterPro
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF00096, zf-C2H2, 4 hits
SMARTiView protein in SMART
SM00355, ZnF_C2H2, 4 hits
SUPFAMiSSF57667, SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 3 hits
PS50157, ZINC_FINGER_C2H2_2, 4 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH2MV82_ORYLA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H2MV82
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 21, 2012
Last sequence update: December 5, 2018
Last modified: June 2, 2021
This is version 50 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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