UniProtKB - H2M8J9 (H2M8J9_ORYLA)
Protein
NR LBD domain-containing protein
Gene
dax1
Organism
Oryzias latipes (Japanese rice fish) (Japanese killifish)
Status
Functioni
GO - Molecular functioni
- transcription corepressor activity Source: GO_Central
- transcription factor binding Source: GO_Central
GO - Biological processi
- negative regulation of DNA-binding transcription factor activity Source: GO_Central
- negative regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | ReceptorARBA annotation, RepressorARBA annotation |
Biological process | Transcription, Transcription regulationARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: NR LBD domain-containing proteinInterPro annotation |
Gene namesi | Name:dax1Imported |
Organismi | Oryzias latipes (Japanese rice fish) (Japanese killifish)Imported |
Taxonomic identifieri | 8090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Neoteleostei › Acanthomorphata › Ovalentaria › Atherinomorphae › Beloniformes › Adrianichthyidae › Oryziinae › Oryzias |
Proteomesi |
|
Interactioni
GO - Molecular functioni
- transcription factor binding Source: GO_Central
Protein-protein interaction databases
STRINGi | 8090.ENSORLP00000014816 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 37 – 287 | NR LBDInterPro annotationAdd BLAST | 251 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 218 – 238 | Sequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
eggNOGi | KOG3575, Eukaryota |
GeneTreei | ENSGT00390000015719 |
HOGENOMi | CLU_093194_0_0_1 |
InParanoidi | H2M8J9 |
OMAi | RCLHYIQ |
TreeFami | TF332386 |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit |
InterProi | View protein in InterPro IPR035500, NHR-like_dom_sf IPR033544, NR0B1/2 IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt |
PANTHERi | PTHR24081, PTHR24081, 2 hits |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit |
PRINTSi | PR00398, STRDHORMONER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit |
i Sequence
Sequence statusi: Complete.
H2M8J9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MATLESCRCR GASGQTNSSI LYSILKNESA DEQQPRSHQH ALQHLLQKTP
60 70 80 90 100
SSCAPTPLLD PQQQACSCGS TRRRGVLRSP QVTCKAASAV LVKTLRFVKN
110 120 130 140 150
VPCFRELPED DQLLLIRSGW ASLLVLGLAQ DRVDFDTTET VEPSMLQRIL
160 170 180 190 200
TGLPHRQSEP QPGHSRTAAG VSVVDIEAIK AFLKKCWSVD ISTKEYAYLK
210 220 230 240 250
GAVLFNPDLQ GLRCQHYIQS LRREAHEALN EHVRLVQRED TTRFAKLLIA
260 270 280
LSMLRTISPP VVAQLFFRPV IGTVNIEEVL MEMFYGK
Genome annotation databases
Ensembli | ENSORLT00000014817; ENSORLP00000014816; ENSORLG00000011824 |
Similar proteinsi
Cross-referencesi
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 8090.ENSORLP00000014816 |
Genome annotation databases
Ensembli | ENSORLT00000014817; ENSORLP00000014816; ENSORLG00000011824 |
Phylogenomic databases
eggNOGi | KOG3575, Eukaryota |
GeneTreei | ENSGT00390000015719 |
HOGENOMi | CLU_093194_0_0_1 |
InParanoidi | H2M8J9 |
OMAi | RCLHYIQ |
TreeFami | TF332386 |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit |
InterProi | View protein in InterPro IPR035500, NHR-like_dom_sf IPR033544, NR0B1/2 IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt |
PANTHERi | PTHR24081, PTHR24081, 2 hits |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit |
PRINTSi | PR00398, STRDHORMONER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | H2M8J9_ORYLA | |
Accessioni | H2M8J9Primary (citable) accession number: H2M8J9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 21, 2012 |
Last sequence update: | March 21, 2012 | |
Last modified: | October 7, 2020 | |
This is version 57 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |