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Entry version 61 (16 Oct 2019)
Sequence version 1 (21 Mar 2012)
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Protein
Submitted name:

TRansport Protein Particle

Gene

trpp-8

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
TRansport Protein ParticleImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:trpp-8Imported
ORF Names:CELE_F46F11.9Imported, F46F11.9Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

WormBase

More...
WormBasei
F46F11.9a ; CE30536 ; WBGene00018512 ; trpp-8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
H2L043

PeptideAtlas

More...
PeptideAtlasi
H2L043

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00018512 Expressed in 5 organ(s), highest expression level in adult organism

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
H2L043 baseline and differential

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
H2L043

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni245 – 287DisorderedSequence analysisAdd BLAST43

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi249 – 287PolarSequence analysisAdd BLAST39

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1938 Eukaryota
ENOG410XPCJ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000000568

KEGG Orthology (KO)

More...
KOi
K20305

Database of Orthologous Groups

More...
OrthoDBi
625387at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR024420 TRAPP_III_complex_Trs85

The PANTHER Classification System

More...
PANTHERi
PTHR12975 PTHR12975, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12739 TRAPPC-Trs85, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

H2L043-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSVSPSPLI ALISSECSQK HAHNRGFKSL SHFIFPFTSH ECQVREPIDN
60 70 80 90 100
LKASQRIRLD IRDISSDGHL LTLSVLPYVL IQALKTCTDV SQSIKLFRDV
110 120 130 140 150
LARCSEPSEH ESFGHYLACI FVVSTEDENP LGEFSKMIQT QQTLYNTTST
160 170 180 190 200
LMIPGHCSTP KWAAPHAKTP RHYILLHDSR SPRSSTERRD ELLAQMCATY
210 220 230 240 250
GNDNCQMLQL DSDSESAEMK GVWDEIDEFN DVLEKGLEEA HQHSTDAIAP
260 270 280 290 300
GPNGASNQQS PSSPTSSVAT ISSTMPAVGS VSPNSHPNST VVWKSSKKLA
310 320 330 340 350
SLADAKAVQA ILSKFLDVCL IPYVEKEMRF LYETAGQKKG IGKSFTSMKR
360 370 380 390 400
WFGSGTALSN MATPITYAWD SSEMQTRRLA DLLLMFGFPN SAFEQYRGLK
410 420 430 440 450
RDLEADKAMA AHAVALEMCC VALHSAQPQL NANQFMIKYL ETPVSLLIEH
460 470 480 490 500
AKRYPSILRC AFNIADIYSD LGLHKEAALN LAKVSSIEGD HLVAVAQTLA
510 520 530 540 550
AEQFEKAGMG RKASFHRVLA ANRFSNAAIP ALSFDCYRLA LPAFDKKHWG
560 570 580 590 600
VLDEHLAVRL LEEGQKAGVM TTDIASECIR RLVAVCPKLS PSLQTERLRT
610 620 630 640 650
IVNALDIYFP HRNEPVEMLT DIPKVEMETV KAIYGERPLW NEIDENEHQS
660 670 680 690 700
VSSDGWITVE RAAHHALFGA SAPYRGMQLV SDEHSDNQKI RETPAGERFR
710 720 730 740 750
VMVDLTNPLK IPIHLQNLRL SVSDIHNQSG IEGSEKSIPE LGALEHLQLD
760 770 780 790 800
PEETKTIELY VFPRVGCLKF RVDGLLFQLA VDQKDVEARV PLKCRGKRLN
810 820 830 840 850
KTAKQQKSKI YTNDERLSAT VAQKPWPLVE FRVIKSPHQW SYCDQAQRYQ
860 870 880 890 900
LEIENIGHEN VMSMCLATNA FDRVAAGSID ENEHHQQFKM NLAANNAKVA
910 920 930 940 950
TFRFEEGSTS STDSFLKIGE KKRIFFDVRS SDEPTGSTVA PKQSNTVILI
960 970 980 990 1000
AYRSSNGTMR QWRRVIDGER RRLIALTAEI LDLDTKSFSI HLKNCVAVSQ
1010 1020 1030 1040 1050
AALSRVEILR IRTDRNEAST GIKNDCSTTV LPSVNRRVEI ESEQTDTIVA
1060 1070 1080 1090 1100
RLVPLSQGET IKESWLTTTT SVTPPKWPCP AEIHSTMDDE FASKIAEKIG
1110 1120 1130 1140 1150
ILWKANIVNN EGLVTSFIGE SFIDDPFVKL KTLKKDDSVL SSLRISCETT
1160 1170 1180 1190 1200
AKEISHNFSA SHICELPITL LIQNKDLQRR PVSVSIKLSS KVREPVDGIH
1210 1220 1230 1240 1250
LVAPENRHQM WIDRPVRKQT IGIDDEAKLE MKWKITHAAV YDVGGANLSI
1260 1270 1280
EAIFEGSNDA VIFKVPSVLS VVKSSSYTVV
Length:1,280
Mass (Da):142,776
Last modified:March 21, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE60D43001CA4A6AF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9BI63Q9BI63_CAEEL
TRansport Protein Particle
trpp-8 CELE_F46F11.9, F46F11.9
1,282Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX284601 Genomic DNA Translation: CCD71331.1

NCBI Reference Sequences

More...
RefSeqi
NP_491643.2, NM_059242.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
F46F11.9a.1; F46F11.9a.1; WBGene00018512

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
172217

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_F46F11.9

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284601 Genomic DNA Translation: CCD71331.1
RefSeqiNP_491643.2, NM_059242.4

3D structure databases

SMRiH2L043
ModBaseiSearch...

Proteomic databases

EPDiH2L043
PeptideAtlasiH2L043

Genome annotation databases

EnsemblMetazoaiF46F11.9a.1; F46F11.9a.1; WBGene00018512
GeneIDi172217
KEGGicel:CELE_F46F11.9

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
172217
WormBaseiF46F11.9a ; CE30536 ; WBGene00018512 ; trpp-8

Phylogenomic databases

eggNOGiKOG1938 Eukaryota
ENOG410XPCJ LUCA
GeneTreeiENSGT00390000000568
KOiK20305
OrthoDBi625387at2759

Gene expression databases

BgeeiWBGene00018512 Expressed in 5 organ(s), highest expression level in adult organism
ExpressionAtlasiH2L043 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR024420 TRAPP_III_complex_Trs85
PANTHERiPTHR12975 PTHR12975, 1 hit
PfamiView protein in Pfam
PF12739 TRAPPC-Trs85, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH2L043_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H2L043
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 21, 2012
Last sequence update: March 21, 2012
Last modified: October 16, 2019
This is version 61 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health

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