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Entry version 66 (16 Oct 2019)
Sequence version 1 (21 Mar 2012)
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Protein

Tyrosine-protein kinase receptor svh-2

Gene

svh-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor tyrosine kinase which may phosphorylate mlk-1, a component of the mlk-1, mek-1 and kgb-1 pathway (PubMed:22388962). Involved in axon regeneration after injury by promoting the generation of productive and stable growth cones (PubMed:22388962, PubMed:27984580).2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei767ATPPROSITE-ProRule annotation1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei767Required for shc-1 interaction1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei858Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi741 – 749ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Receptor, Transferase, Tyrosine-protein kinase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-202733 Cell surface interactions at the vascular wall

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tyrosine-protein kinase receptor svh-2Curated (EC:2.7.10.1PROSITE-ProRule annotation2 Publications)
Alternative name(s):
Met/Ron-like receptor tyrosine kinase svh-21 Publication
Suppressor of vhp-1 deletion lethality protein svh-2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:svh-2Imported
ORF Names:T14E8.1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

WormBase

More...
WormBasei
T14E8.1a ; CE28667 ; WBGene00020504 ; svh-2
T14E8.1b ; CE29341 ; WBGene00020504 ; svh-2
T14E8.1c ; CE37148 ; WBGene00020504 ; svh-2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini35 – 651ExtracellularSequence analysisAdd BLAST617
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei652 – 672HelicalSequence analysisAdd BLAST21
Topological domaini673 – 1086CytoplasmicSequence analysisAdd BLAST414

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Viable. Reduced axon regeneration 24 hours following injury of D-type motor neurons.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi767K → R: Abolished interaction with shc-1. Probable loss of kinase activity. Loss of phosphorylation at Y-890. Impaired axon regeneration following injury. 2 Publications1
Mutagenesisi890Y → F: Abolishes phosphorylation. Impaired axon regeneration following injury. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 34Sequence analysisAdd BLAST34
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000043416335 – 1086Tyrosine-protein kinase receptor svh-2CuratedAdd BLAST1052

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi276N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi299N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi461N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi554N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi617N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei890Phosphotyrosine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

May be autophosphorylated on Tyr-890 following dimerization.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
H2KZU7

PeptideAtlas

More...
PeptideAtlasi
H2KZU7

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
H2KZU7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in body wall and vulva muscles, pharynx, intestine, excretory canals, distal tip cells and some neurons. Expressed in D-type motor neurons upon axon injury.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00020504 Expressed in 4 organ(s), highest expression level in multi-cellular organism

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via cytoplasmic domain) with mlk-1 (PubMed:22388962).

Interacts with shc-1 (via SH2 domain) (PubMed:27984580).

2 Publications

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
6239.T14E8.1a

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
H2KZU7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini735 – 996Protein kinasePROSITE-ProRule annotationAdd BLAST262

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IQAB Eukaryota
ENOG410XRIK LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000168249

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000019317

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
H2KZU7

KEGG Orthology (KO)

More...
KOi
K05099

Identification of Orthologs from Complete Genome Data

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OMAi
VIWELFT

Database of Orthologous Groups

More...
OrthoDBi
163404at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR036352 Semap_dom_sf
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
IPR015943 WD40/YVTN_repeat-like_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07714 Pkinase_Tyr, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00109 TYRKINASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00219 TyrKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF101912 SSF101912, 1 hit
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform aImported (identifier: H2KZU7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVLGSSQSSA KELTTQSSIF RFLVLLLCFT SATGGQINGK LLNGNGVFVS
60 70 80 90 100
RDELQNKNVL GVITGFDLLV VATHSRFQVF ENNEERRTVG HVSLDMHPRT
110 120 130 140 150
KFLELKLFSK SEIFYCDESS CGLCTYSGVT SSCSTFMLNG DEPKIQEILS
160 170 180 190 200
SSAVKIENLG QIMLAISFKN EEDPDNPRTM ILRYNAQDTG TVIPTAYHAD
210 220 230 240 250
SSFIHNNHAL TGFEREGFVY FVMTASQIFE PEVFLHDQSN NKVTVTKVIR
260 270 280 290 300
FCATDQTADL ASKISILVGC DQEFRNISSR GETAVYDHAN DLINIVMFNH
310 320 330 340 350
TSMNHLMCRF KMANIEKRFK TIWSTCQETS FSGSTAKTTR CKYPQIFDQM
360 370 380 390 400
KVKKGCLTYS RLDDESSPTL CVRYGRGDAL DNCQLHTAKS NSYRYGWLED
410 420 430 440 450
YNVLQGELMM RIPYPFFGIA ESLITDGKSY FAAVSGEFDM SDVLRFSASE
460 470 480 490 500
SADIRPHWRT NISVVGKFSI TKTKENQLLY TTVEGLQSLD ISCKGLYPNC
510 520 530 540 550
QTLRQGGWED PLECSWCADD NAQRTITSSE VSSCKNNLKH ECPPSMRWIH
560 570 580 590 600
KYNNNSGFTA VVDGFRALKN PKLNACGTNC VVTVVDSSSI QCDTNPDEVI
610 620 630 640 650
GDSCKQVFLS GMIGDKNYSF PFDYQQADRG TQTDVKNSQV DDKKGSSPGW
660 670 680 690 700
KIAIAIISVM TIILIVAIIV YYMRNRFPRI KTHVRPPIGQ RIENEYDMGH
710 720 730 740 750
MAGRQAQLAI NGDNYVKVFR SMRPDLKVDF KNLRVDKLDP IGQGHYGVVY
760 770 780 790 800
KAMYSPSKSL EEKVVCKYLK EGKISEFYEE ARTMSEFDHP NILKLIGVAL
810 820 830 840 850
DDSSHLPIII TEYMAKGDLK SFIENVENTI KMRDLFEFAF DIAKGMNYMH
860 870 880 890 900
SKKFIHRDLA CRNCLLDEHL RVKIADFGLC RKVDIETELY VQMHERDLPV
910 920 930 940 950
RWFPPEISEQ GFGITSDIWS FGVVIWELFT RGSTPYSNMA SWILILPWLK
960 970 980 990 1000
ESETNRLRKP PYCPEKLYTD VMLACWKANP AERPQFSDLV TIIPNVVKYM
1010 1020 1030 1040 1050
EGYDRSQLQA GYERVSSRFL SLSRHDPAFP IYQNEMPNTP LLANCQNDTN
1060 1070 1080
DSKTLAELPS DSPSTSTAIP QSTPYQLLSE CSETSV
Note: No experimental confirmation available.Curated
Length:1,086
Mass (Da):122,895
Last modified:March 21, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i58BD2277423F77E0
GO
Isoform bImported (identifier: H2KZU7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1017-1030: SRFLSLSRHDPAFP → ELVTSRPSISNLSE
     1031-1086: Missing.

Show »
Length:1,030
Mass (Da):116,768
Checksum:i91D7024FEBE58C33
GO
Isoform cImported (identifier: H2KZU7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1018-1018: R → F
     1019-1086: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:1,018
Mass (Da):115,489
Checksum:iAA0719DCE853C738
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0579161017 – 1030SRFLS…DPAFP → ELVTSRPSISNLSE in isoform b. CuratedAdd BLAST14
Alternative sequenceiVSP_0579171018R → F in isoform c. Curated1
Alternative sequenceiVSP_0579191019 – 1086Missing in isoform c. CuratedAdd BLAST68
Alternative sequenceiVSP_0579181031 – 1086Missing in isoform b. CuratedAdd BLAST56

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB693147 mRNA Translation: BAL45942.1
BX284606 Genomic DNA Translation: CCD83400.1
BX284606 Genomic DNA Translation: CCD83401.1
BX284606 Genomic DNA Translation: CCD83402.1

NCBI Reference Sequences

More...
RefSeqi
NP_001024906.1, NM_001029735.3 [H2KZU7-3]
NP_509104.1, NM_076703.6 [H2KZU7-1]
NP_509105.1, NM_076704.4 [H2KZU7-2]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
T14E8.1a.1; T14E8.1a.1; WBGene00020504 [H2KZU7-1]
T14E8.1b.1; T14E8.1b.1; WBGene00020504 [H2KZU7-2]
T14E8.1b.2; T14E8.1b.2; WBGene00020504 [H2KZU7-2]
T14E8.1c.1; T14E8.1c.1; WBGene00020504 [H2KZU7-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
180929

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
cel:CELE_T14E8.1

UCSC genome browser

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UCSCi
T14E8.1c c. elegans

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB693147 mRNA Translation: BAL45942.1
BX284606 Genomic DNA Translation: CCD83400.1
BX284606 Genomic DNA Translation: CCD83401.1
BX284606 Genomic DNA Translation: CCD83402.1
RefSeqiNP_001024906.1, NM_001029735.3 [H2KZU7-3]
NP_509104.1, NM_076703.6 [H2KZU7-1]
NP_509105.1, NM_076704.4 [H2KZU7-2]

3D structure databases

SMRiH2KZU7
ModBaseiSearch...

Protein-protein interaction databases

STRINGi6239.T14E8.1a

PTM databases

iPTMnetiH2KZU7

Proteomic databases

PaxDbiH2KZU7
PeptideAtlasiH2KZU7

Genome annotation databases

EnsemblMetazoaiT14E8.1a.1; T14E8.1a.1; WBGene00020504 [H2KZU7-1]
T14E8.1b.1; T14E8.1b.1; WBGene00020504 [H2KZU7-2]
T14E8.1b.2; T14E8.1b.2; WBGene00020504 [H2KZU7-2]
T14E8.1c.1; T14E8.1c.1; WBGene00020504 [H2KZU7-3]
GeneIDi180929
KEGGicel:CELE_T14E8.1
UCSCiT14E8.1c c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
180929
WormBaseiT14E8.1a ; CE28667 ; WBGene00020504 ; svh-2
T14E8.1b ; CE29341 ; WBGene00020504 ; svh-2
T14E8.1c ; CE37148 ; WBGene00020504 ; svh-2

Phylogenomic databases

eggNOGiENOG410IQAB Eukaryota
ENOG410XRIK LUCA
GeneTreeiENSGT00940000168249
HOGENOMiHOG000019317
InParanoidiH2KZU7
KOiK05099
OMAiVIWELFT
OrthoDBi163404at2759

Enzyme and pathway databases

ReactomeiR-CEL-202733 Cell surface interactions at the vascular wall

Miscellaneous databases

Protein Ontology

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PROi
PR:H2KZU7

Gene expression databases

BgeeiWBGene00020504 Expressed in 4 organ(s), highest expression level in multi-cellular organism

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR036352 Semap_dom_sf
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
IPR015943 WD40/YVTN_repeat-like_dom_sf
PfamiView protein in Pfam
PF07714 Pkinase_Tyr, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00219 TyrKc, 1 hit
SUPFAMiSSF101912 SSF101912, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSVH2_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H2KZU7
Secondary accession number(s): H1AGA1, Q6AHP3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 14, 2015
Last sequence update: March 21, 2012
Last modified: October 16, 2019
This is version 66 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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