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Entry version 67 (07 Apr 2021)
Sequence version 1 (21 Mar 2012)
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Protein

Nuclear protein localization protein 4 homolog 1

Gene

npl-4.1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

In association with ufd-1 and ATPase cdc-48.1 and/or cdc-48.2, involved in the cytoplasmic elimination of misfolded proteins exported from the ER (PubMed:16647269, PubMed:22768338).

This pathway, known as ERAD, prevents the activation of the unfolded protein response (UPR) caused by the accumulation of misfolded proteins in the ER (PubMed:16647269, PubMed:22768338).

During S phase and in association with ufd-1, cdc-48.1 and/or cdc-48.2 and ubxn-3, ensures the degradation of DNA licensing factor cdt-1 after the initiation of DNA replication and thus the disassembly of the DNA replication CGM helicase complex by promoting the dissociation from chromatin of several of its components including cdc-45 and sld-5 (PubMed:18728180, PubMed:21981920, PubMed:26842564, PubMed:28368371).

Regulates ubxn-3 nuclear localization during S phase (PubMed:26842564).

6 Publications

Caution

There is another gene, npl-4.2, which has a 99% identical sequence making it difficult to identify the specific function for each protein.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri499 – 529RanBP2-typePROSITE-ProRule annotationAdd BLAST31

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChaperone
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nuclear protein localization protein 4 homolog 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:npl-4.1Imported
ORF Names:F59E12.4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

WormBase

More...
WormBasei
F59E12.4a ; CE28572 ; WBGene00019120 ; npl-4.1
F59E12.4b ; CE28573 ; WBGene00019120 ; npl-4.1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Simultaneous RNAi-mediated knockdown of npl-4.1 and npl-4.2 causes embryonic lethality (PubMed:16647269, PubMed:26842564). In embryos, DNA replication is partially impaired causing a delay in S phase progression in P0, AB and P1 cells; simultaneous RNAi-mediated knockdown of DNA replication checkpoint kinases chk-1 or atl-1 suppresses the delay in S phase (PubMed:18728180, PubMed:26842564). During S phase, prevents DNA replication licensing factor cdt-1 down-regulation and causes cdt-1 accumulation on mitotic chromosomes (PubMed:21981920). Impairs dissociation from the chromatin of components of the DNA replication machinery, including cdc-45, GINS complex component sld-5 and CMG helicase component mcm-3, resulting in their persistent association with chromatin throughout embryonic mitosis (PubMed:21981920, PubMed:26842564, PubMed:28368371). Abnormal ubxn-3 localization into punctate structures in the nucleus (PubMed:26842564). Reduces ufd-1 expression in embryos (PubMed:21981920, PubMed:26842564). Simultaneous RNAi-mediated knockdown of npl-4.1 and npl-4.2 in adults causes a proliferation arrest of mitotic germline cells in the gonad with formation of rad-51 foci on chromatin (PubMed:18728180). Induces the unfolded protein response and increases sensitivity to tunicamycin-induced ER stress (PubMed:16647269). Causes accumulation of misfolded protein cpl-1 in the ER (PubMed:22768338).5 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004450841 – 529Nuclear protein localization protein 4 homolog 1Add BLAST529

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
H2KYU6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
H2KYU6

PeptideAtlas

More...
PeptideAtlasi
H2KYU6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00019120, Expressed in adult organism and 3 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms a complex composed of ubxn-3, ufd-1, npl-4.1 and cdc-48.1; within the complex, interacts with ufd-1 and ubxn-3 (PubMed:20977550).

Interacts with ufd-1 (PubMed:16647269).

Interacts with elc-1/elongin C; the interaction may mediate the interaction between the npl-4-ufd-1-cdc-48 complex and the E3 ubiquitin ligase cul-2 complex (PubMed:19773360).

3 Publications

GO - Molecular functioni

Protein-protein interaction databases

Database of interacting proteins

More...
DIPi
DIP-25816N

Protein interaction database and analysis system

More...
IntActi
H2KYU6, 2 interactors

STRING: functional protein association networks

More...
STRINGi
6239.F59E12.4b

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
H2KYU6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini129 – 266MPNPROSITE-ProRule annotationAdd BLAST138

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NPL4 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri499 – 529RanBP2-typePROSITE-ProRule annotationAdd BLAST31

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2834, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000018731

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_017172_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
H2KYU6

Identification of Orthologs from Complete Genome Data

More...
OMAi
MAYINET

Database of Orthologous Groups

More...
OrthoDBi
1106766at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
H2KYU6

Family and domain databases

Conserved Domains Database

More...
CDDi
cd08061, MPN_NPL4, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR037518, MPN
IPR016563, Npl4
IPR007717, NPL4_C
IPR007716, NPL4_Zn-bd_put
IPR001876, Znf_RanBP2
IPR036443, Znf_RanBP2_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05021, NPL4, 1 hit
PF05020, zf-NPL4, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF010052, Polyub_prc_Npl4, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00547, ZnF_RBZ, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF90209, SSF90209, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50249, MPN, 1 hit
PS01358, ZF_RANBP2_1, 1 hit
PS50199, ZF_RANBP2_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform bImported (identifier: H2KYU6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVLEVPQTER VNDVDVFLST QDGQIQRPKG PNCRHPVRQK CTNCLPVDPF
60 70 80 90 100
DEEYLKEKDI KHMSFHAHVR KLLGSQGKGT TLKKPLENFR CSLKPNCDAH
110 120 130 140 150
KPFPKGICTK CKPQVVTLNR QKFRHVDNIQ IENQELVNQF LDYWRLSGHQ
160 170 180 190 200
RVGFLIGQYQ PHLEVPLGIK ATVAAIYEPP QHCREDGIEF LEDKNQKTID
210 220 230 240 250
NLLEMLGLQR VGWIFTDCWT ANSAEGTVHY TRHKDSFFLS AEECITAAML
260 270 280 290 300
QNQHPNITEY SMDRHYGSKF VTVVASGDES MHVNFHGYQV SNQCAAMVEA
310 320 330 340 350
DILCPTLYTP ELAYVRETPL SEEHYITDVQ FSMKNEYGAE VMKNGRPLPV
360 370 380 390 400
EYLLVDVPAG MPKEPHYTFH VGTSNKSKSA KFNVENRQAI GQLQGGANLI
410 420 430 440 450
QYSSEFSKNQ FLEQATNFHF LLYLVTNDQV QISDEWMKRL CDAVKAQDRG
460 470 480 490 500
TAMEWAQECE DWHQLMALAH ANGGSGNDVS DIPVIPNGDP FSGSSSGGSG
510 520
GAVWNCGHCT FQNEAARQDC SMCGLPAAD
Length:529
Mass (Da):59,579
Last modified:March 21, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF1358139A3ED1D47
GO
Isoform aImported (identifier: H2KYU6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     479-480: Missing.

Show »
Length:527
Mass (Da):59,393
Checksum:i5B0B95B0B80FB61F
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_059819479 – 480Missing in isoform a. Curated2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX284602 Genomic DNA Translation: CCD64968.1
BX284602 Genomic DNA Translation: CCD64969.1

NCBI Reference Sequences

More...
RefSeqi
NP_495096.1, NM_062695.4 [H2KYU6-1]
NP_495097.1, NM_062696.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
F59E12.4a.1; F59E12.4a.1; WBGene00019120 [H2KYU6-2]
F59E12.4b.1; F59E12.4b.1; WBGene00019120 [H2KYU6-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
173952

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_F59E12.4

UCSC genome browser

More...
UCSCi
F59E12.4a, c. elegans

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284602 Genomic DNA Translation: CCD64968.1
BX284602 Genomic DNA Translation: CCD64969.1
RefSeqiNP_495096.1, NM_062695.4 [H2KYU6-1]
NP_495097.1, NM_062696.4

3D structure databases

SMRiH2KYU6
ModBaseiSearch...

Protein-protein interaction databases

DIPiDIP-25816N
IntActiH2KYU6, 2 interactors
STRINGi6239.F59E12.4b

Proteomic databases

EPDiH2KYU6
PaxDbiH2KYU6
PeptideAtlasiH2KYU6

Genome annotation databases

EnsemblMetazoaiF59E12.4a.1; F59E12.4a.1; WBGene00019120 [H2KYU6-2]
F59E12.4b.1; F59E12.4b.1; WBGene00019120 [H2KYU6-1]
GeneIDi173952
KEGGicel:CELE_F59E12.4
UCSCiF59E12.4a, c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
173952
WormBaseiF59E12.4a ; CE28572 ; WBGene00019120 ; npl-4.1
F59E12.4b ; CE28573 ; WBGene00019120 ; npl-4.1

Phylogenomic databases

eggNOGiKOG2834, Eukaryota
GeneTreeiENSGT00390000018731
HOGENOMiCLU_017172_2_0_1
InParanoidiH2KYU6
OMAiMAYINET
OrthoDBi1106766at2759
PhylomeDBiH2KYU6

Miscellaneous databases

Protein Ontology

More...
PROi
PR:H2KYU6

Gene expression databases

BgeeiWBGene00019120, Expressed in adult organism and 3 other tissues

Family and domain databases

CDDicd08061, MPN_NPL4, 1 hit
InterProiView protein in InterPro
IPR037518, MPN
IPR016563, Npl4
IPR007717, NPL4_C
IPR007716, NPL4_Zn-bd_put
IPR001876, Znf_RanBP2
IPR036443, Znf_RanBP2_sf
PfamiView protein in Pfam
PF05021, NPL4, 1 hit
PF05020, zf-NPL4, 1 hit
PIRSFiPIRSF010052, Polyub_prc_Npl4, 1 hit
SMARTiView protein in SMART
SM00547, ZnF_RBZ, 1 hit
SUPFAMiSSF90209, SSF90209, 1 hit
PROSITEiView protein in PROSITE
PS50249, MPN, 1 hit
PS01358, ZF_RANBP2_1, 1 hit
PS50199, ZF_RANBP2_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNPL41_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H2KYU6
Secondary accession number(s): Q95QZ7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 12, 2018
Last sequence update: March 21, 2012
Last modified: April 7, 2021
This is version 67 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families
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