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Entry version 57 (07 Oct 2020)
Sequence version 1 (21 Mar 2012)
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Protein
Submitted name:

Transcriptional regulator

Gene

SHJG_4965

Organism
Streptomyces hygroscopicus subsp. jinggangensis (strain 5008)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi1 – 83OmpR/PhoB-typePROSITE-ProRule annotationAdd BLAST83

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotationARBA annotation
Biological processTwo-component regulatory systemARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Transcriptional regulatorImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:SHJG_4965Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiStreptomyces hygroscopicus subsp. jinggangensis (strain 5008)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1133850 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007170 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
1133850.SHJG_4965

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 83OmpR/PhoB-typeInterPro annotationAdd BLAST83

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni230 – 293DisorderedSequence analysisAdd BLAST64

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili657 – 677Sequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the AfsR/DnrI/RedD regulatory family.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG3629, Bacteria
COG3903, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_004665_1_3_11

Identification of Orthologs from Complete Genome Data

More...
OMAi
FAGGWDL

Database of Orthologous Groups

More...
OrthoDBi
1377603at2

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.10, 1 hit
1.25.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005158, BTAD
IPR001867, OmpR/PhoB-type_DNA-bd
IPR027417, P-loop_NTPase
IPR016032, Sig_transdc_resp-reg_C-effctor
IPR011990, TPR-like_helical_dom_sf
IPR036388, WH-like_DNA-bd_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03704, BTAD, 1 hit
PF00486, Trans_reg_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01043, BTAD, 1 hit
SM00862, Trans_reg_C, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46894, SSF46894, 1 hit
SSF48452, SSF48452, 2 hits
SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51755, OMPR_PHOB, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

H2JYS1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTQAADDQGT PVPIGGRRLR TLLAALALRP GRTTAPRTLV EEIWADDPPQ
60 70 80 90 100
DAPAALQALV GRLRRTLGRH TIASTPGGYR LEAAEDEVDL HVFERLAHTG
110 120 130 140 150
TQALTAGDPA TAHRALTQAL ALWYGPALAD LPDRTAAARP EALRLEAARA
160 170 180 190 200
RAAASLALGR AREAVPELRE LTTVHPYDEA LHALLIRALR DTGRPADALA
210 220 230 240 250
AYESARRTLA DSLGTDPGPE LQSLHTSLLK PEPLDAPGYQ ETAKPTHAPE
260 270 280 290 300
HLEPPKPAYA PEYLESPKPA HTSWHPAHPA YPAPPKPPGR TGNLRPRLTS
310 320 330 340 350
FVGREPELKA IRSDVHRARL VTLTGPGGSG KTRLAEEAAA PLPSAWLVEL
360 370 380 390 400
APLDRPEAVP GAVVSALGLR ETVLLTNELA TPQADPTALL IEYCAPRSHL
410 420 430 440 450
LILDNCEHVI GAAAALAETL LTHCPGLTIL ATSREPLGVP GESVRPVEPL
460 470 480 490 500
VPEQAHRLFT ERAKAVRPDA DAVLGDTEAV AEICRRLDGL PLAIELAAAR
510 520 530 540 550
LRLLTPRQIA DRLDDRFRLL TSGSRTVLPR QQTLRAVVDW SWELLDERER
560 570 580 590 600
TVLREVSVFA GGWDLAAAEA VCTGPAADLI GALVDKSLVV AAPHDPDGTG
610 620 630 640 650
AGMRYRMLET IHEYATERAA EVPGLRAAAE RRHRAWVRAL VEEAEPRLRS
660 670 680 690 700
AAQLPWIARL ETELDNIRAA LDRAVRAGDE AEAGAVVLAT GWFWWLRNHR
710 720 730 740 750
QEAVAWVRLV LRLGIALDTL PAGAPADEVR ARAKTADPVG AFLAAPDGEA
760 770 780 790 800
GHPLRELRMD LRMLDLFLTA ETGTESLAAD ERTREYLARV RAAYEGGGPQ
810 820 830 840 850
AARLPGIIWP LTSYYLGGPT DIGPQMTQCV ANCRRYGGDW ELGVALMYRA
860 870 880 890 900
HVTVDSPGNL RGVDEDLAEL RTLGRRVGDR WMRAQICSAT GEAAMVRGRY
910 920 930 940 950
EEARGEYEEA LRLAYEVGAY AESPFLIARL AEISYRSGDR EAALAALDEA
960 970 980 990 1000
GTAADRYAVP ESRAFVLLLR AHIALHDNQH AQARELYEAT RAVIRDGTPP
1010 1020 1030 1040 1050
PQFVAAQRMA EALIEAHGSG PAHGLPILAK ALREAVDHRC AESITAGLVD
1060 1070 1080 1090 1100
VAAGLLARLG DLPGALRLFA AADHWRDGLD RPEPERGEAA RVRATARAAL
1110 1120 1130
PADRYAAECA RGASFGVADV LRELGAGTAT GR
Length:1,132
Mass (Da):121,966
Last modified:March 21, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i24B8AC31F4F2F9E9
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CP003275 Genomic DNA Translation: AEY90233.1

NCBI Reference Sequences

More...
RefSeqi
WP_014673557.1, NC_017765.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AEY90233; AEY90233; SHJG_4965

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
shy:SHJG_4965

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1133850.20.peg.5492

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003275 Genomic DNA Translation: AEY90233.1
RefSeqiWP_014673557.1, NC_017765.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi1133850.SHJG_4965

Genome annotation databases

EnsemblBacteriaiAEY90233; AEY90233; SHJG_4965
KEGGishy:SHJG_4965
PATRICifig|1133850.20.peg.5492

Phylogenomic databases

eggNOGiCOG3629, Bacteria
COG3903, Bacteria
HOGENOMiCLU_004665_1_3_11
OMAiFAGGWDL
OrthoDBi1377603at2

Family and domain databases

Gene3Di1.10.10.10, 1 hit
1.25.40.10, 2 hits
InterProiView protein in InterPro
IPR005158, BTAD
IPR001867, OmpR/PhoB-type_DNA-bd
IPR027417, P-loop_NTPase
IPR016032, Sig_transdc_resp-reg_C-effctor
IPR011990, TPR-like_helical_dom_sf
IPR036388, WH-like_DNA-bd_sf
PfamiView protein in Pfam
PF03704, BTAD, 1 hit
PF00486, Trans_reg_C, 1 hit
SMARTiView protein in SMART
SM01043, BTAD, 1 hit
SM00862, Trans_reg_C, 1 hit
SUPFAMiSSF46894, SSF46894, 1 hit
SSF48452, SSF48452, 2 hits
SSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51755, OMPR_PHOB, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH2JYS1_STRHJ
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H2JYS1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 21, 2012
Last sequence update: March 21, 2012
Last modified: October 7, 2020
This is version 57 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
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