Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 61 (10 Apr 2019)
Sequence version 1 (21 Mar 2012)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein
Submitted name:

Twitchin

Gene

unc-22

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinaseSAAS annotation, Transferase

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
H2FLH3

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
TwitchinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:unc-22Imported
ORF Names:CELE_ZK617.1Imported, ZK617.1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IV

Organism-specific databases

WormBase

More...
WormBasei
ZK617.1g ; CE46868 ; WBGene00006759 ; unc-22

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
H2FLH3

PeptideAtlas

More...
PeptideAtlasi
H2FLH3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00006759 Expressed in 4 organ(s), highest expression level in material anatomical entity

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
H2FLH3 baseline and differential

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
H2FLH3

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
H2FLH3

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini5 – 97Ig-likeInterPro annotationAdd BLAST93
Domaini111 – 204Ig-likeInterPro annotationAdd BLAST94
Domaini377 – 466Ig-likeInterPro annotationAdd BLAST90
Domaini661 – 753Ig-likeInterPro annotationAdd BLAST93
Domaini812 – 903Ig-likeInterPro annotationAdd BLAST92
Domaini907 – 996Ig-likeInterPro annotationAdd BLAST90
Domaini1002 – 1088Ig-likeInterPro annotationAdd BLAST87
Domaini1288 – 1380Fibronectin type-IIIInterPro annotationAdd BLAST93
Domaini1386 – 1481Fibronectin type-IIIInterPro annotationAdd BLAST96
Domaini1581 – 1678Fibronectin type-IIIInterPro annotationAdd BLAST98
Domaini1684 – 1777Fibronectin type-IIIInterPro annotationAdd BLAST94
Domaini1776 – 1871Ig-likeInterPro annotationAdd BLAST96
Domaini1879 – 1972Fibronectin type-IIIInterPro annotationAdd BLAST94
Domaini1978 – 2073Fibronectin type-IIIInterPro annotationAdd BLAST96
Domaini2173 – 2266Fibronectin type-IIIInterPro annotationAdd BLAST94
Domaini2269 – 2365Fibronectin type-IIIInterPro annotationAdd BLAST97
Domaini2369 – 2453Ig-likeInterPro annotationAdd BLAST85
Domaini2465 – 2558Fibronectin type-IIIInterPro annotationAdd BLAST94
Domaini2564 – 2658Fibronectin type-IIIInterPro annotationAdd BLAST95
Domaini2662 – 2752Ig-likeInterPro annotationAdd BLAST91
Domaini2760 – 2855Fibronectin type-IIIInterPro annotationAdd BLAST96
Domaini2861 – 2955Fibronectin type-IIIInterPro annotationAdd BLAST95
Domaini2958 – 3048Ig-likeInterPro annotationAdd BLAST91
Domaini3055 – 3149Fibronectin type-IIIInterPro annotationAdd BLAST95
Domaini3155 – 3249Fibronectin type-IIIInterPro annotationAdd BLAST95
Domaini3253 – 3343Ig-likeInterPro annotationAdd BLAST91
Domaini3351 – 3443Fibronectin type-IIIInterPro annotationAdd BLAST93
Domaini3449 – 3543Fibronectin type-IIIInterPro annotationAdd BLAST95
Domaini3644 – 3737Fibronectin type-IIIInterPro annotationAdd BLAST94
Domaini3743 – 3836Fibronectin type-IIIInterPro annotationAdd BLAST94
Domaini3936 – 4030Fibronectin type-IIIInterPro annotationAdd BLAST95
Domaini4036 – 4130Fibronectin type-IIIInterPro annotationAdd BLAST95
Domaini4135 – 4221Ig-likeInterPro annotationAdd BLAST87
Domaini4228 – 4321Fibronectin type-IIIInterPro annotationAdd BLAST94
Domaini4327 – 4423Fibronectin type-IIIInterPro annotationAdd BLAST97
Domaini4429 – 4524Fibronectin type-IIIInterPro annotationAdd BLAST96
Domaini4626 – 4718Fibronectin type-IIIInterPro annotationAdd BLAST93
Domaini4724 – 4819Fibronectin type-IIIInterPro annotationAdd BLAST96
Domaini4921 – 5016Fibronectin type-IIIInterPro annotationAdd BLAST96
Domaini5023 – 5117Fibronectin type-IIIInterPro annotationAdd BLAST95
Domaini5120 – 5218Fibronectin type-IIIInterPro annotationAdd BLAST99
Domaini5223 – 5311Ig-likeInterPro annotationAdd BLAST89
Domaini5413 – 5507Fibronectin type-IIIInterPro annotationAdd BLAST95
Domaini5513 – 5609Fibronectin type-IIIInterPro annotationAdd BLAST97
Domaini5613 – 5701Ig-likeInterPro annotationAdd BLAST89
Domaini5706 – 5797Ig-likeInterPro annotationAdd BLAST92
Domaini5804 – 5897Fibronectin type-IIIInterPro annotationAdd BLAST94
Domaini5951 – 6206Protein kinaseInterPro annotationAdd BLAST256
Domaini6275 – 6363Ig-likeInterPro annotationAdd BLAST89
Domaini6386 – 6485Ig-likeInterPro annotationAdd BLAST100
Domaini6553 – 6642Ig-likeInterPro annotationAdd BLAST90
Domaini6648 – 6749Ig-likeInterPro annotationAdd BLAST102
Domaini6757 – 6839Ig-likeInterPro annotationAdd BLAST83

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili473 – 500Sequence analysisAdd BLAST28

Keywords - Domaini

Coiled coilSequence analysis, RepeatSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0613 Eukaryota
ENOG410XQFD LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000169746

Database of Orthologous Groups

More...
OrthoDBi
184at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063 FN3, 31 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 61 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00041 fn3, 31 hits
PF07679 I-set, 27 hits
PF00069 Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060 FN3, 32 hits
SM00409 IG, 30 hits
SM00408 IGc2, 24 hits
SM00220 S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 30 hits
SSF49265 SSF49265, 17 hits
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853 FN3, 31 hits
PS50835 IG_LIKE, 21 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

H2FLH3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVGAPRFTQK PSIQQTPTGD LLMECHLEAD PQPTIAWQHS GNLLEPSGRV
60 70 80 90 100
VQTLTPLGGS LYKATLVIKE PNAGDGGAYK CTARNQLGES NANINLNFAG
110 120 130 140 150
AGGDEAKSRG PSFVGKPRII PKDGGALIVM ECKVKSASTP VAKWMKDGVP
160 170 180 190 200
LSMGGLYHAI FSDLGDQTYL CQLEIRGPSS SDAGQYRCNI RNDQGETNAN
210 220 230 240 250
LALNFEEPDP SERQERKRST ASPRPSSRGP GSRPSSPKKS MKSREGTPKR
260 270 280 290 300
TLKPREGSPS KKLRSRTSTP VNEEVSQSES RRSSRTDKME VDQVSGASKR
310 320 330 340 350
KPDGLPPPGG DEKKLRAGSP STRKSPSRKS ASPTPSRKGS SAGGAASGTT
360 370 380 390 400
GASASATSAT SGGSASSDAS RDKYTRPPIV LEASRSQTGR IGGSVVLEVQ
410 420 430 440 450
WQCHSSTIIE WYRDGTLVRN SSEYSQSFNG SIAKLQVNKL TEEKSGLYKC
460 470 480 490 500
HAKCDYGEGQ SSAMVKIEQS DVEEELMKHR KDAEDEYQKE EQKSQTLQAE
510 520 530 540 550
TKKRVARRSK SKSKSPAPQA KKSTTSESGR QEASEVEHKR SSSVRPDPDE
560 570 580 590 600
ESQLDEIPSS GLTIPEERRR ELLGQVGESD DEVSESISEL PSFAGGKPRR
610 620 630 640 650
KTDDKPKKVS IAPVSTNKSS DDEPSTPRRR SSIDMRRESV QEILEKTSTP
660 670 680 690 700
LVPSGASGSA PKIVEVPENV TVVENETAIL TCKVSGSPAP TFRWFKGSRE
710 720 730 740 750
VISGGRFKHI TDGKEHTVAL ALLKCRSQDE GPYTLTIENV HGTDSADVKL
760 770 780 790 800
LVTSDNGLDF RAMLKHSNQQ RANSKRESQA GFQKDGEGGG AGGGGGEKKP
810 820 830 840 850
MTEAERRQSL FPGKKVEKWD IPLPEKTVQQ QVDKICEWKC TYSRPNAKIR
860 870 880 890 900
WYKDRKEIFS GGLKYKIVIE KNVCTLIINN PEVDDTGKYT CEANGVPTHA
910 920 930 940 950
QLTVLEPPMK YSFLNPLPNT QEIYRTKQAV LTCKVNTPRA PLVWYRGSKA
960 970 980 990 1000
IQEGDPRFII EKDAVGRCTL TIKEVEEDDQ AEWTARITQD VFSKVQVYVE
1010 1020 1030 1040 1050
EPRHTFVVPM KSQKVNESDL ATLETDVNDK DAEVVWWHDG KRIDIDGVKF
1060 1070 1080 1090 1100
KVESSNRKRR LIINGARIED HGEYKCTTKD DRTMAQLIVD AKNKFIVALK
1110 1120 1130 1140 1150
DTEVIEKDDV TLMCQTKDTK TPGIWFRNGK QISSMPGGKF ETQSRNGTHT
1160 1170 1180 1190 1200
LKIGKIEMNE ADVYEIDQAG LRGSCNVTVL EAEKRPILNW KPKKIEAKAG
1210 1220 1230 1240 1250
EPCVVKVPFQ IKGTRRGDPK AQILKNGKPI DEEMRKLVEV IIKDDVAEIV
1260 1270 1280 1290 1300
FKNPQLADTG KWALELGNSA GTALAPFELF VKDKPKPPKG PLETKNVTAE
1310 1320 1330 1340 1350
GLDLVWGTPD PDEGAPVKAY IIEMQEGRSG NWAKVGETKG TDFKVKDLKE
1360 1370 1380 1390 1400
HGEYKFRVKA LNECGLSDPL TGESVLAKNP YGVPGKPKNM DAIDVDKDHC
1410 1420 1430 1440 1450
TLAWEPPEED GGAPITGYII ERREKSEKDW HQVGQTKPDC CELTDKKVVE
1460 1470 1480 1490 1500
DKEYLYRVKA VNKAGPGDPC DHGKPIKMKA KKASPEFTGG GIKDLRLKVG
1510 1520 1530 1540 1550
ETIKYDVPIS GEPLPECLWV VNGKPLKAVG RVKMSSERGK HIMKIENAVR
1560 1570 1580 1590 1600
ADSGKFTITL KNSSGSCDST ATVTVVGRPT PPKGPLDIAD VCADGATLSW
1610 1620 1630 1640 1650
NPPDDDGGDP LTGYIVEAQD MDNKGKYIEV GKVDPNTTTL KVNGLRNKGN
1660 1670 1680 1690 1700
YKFRVKAVNN EGESEPLSAD QYTQIKDPWD EPGKPGRPEI TDFDADRIDI
1710 1720 1730 1740 1750
AWEPPHKDGG APIEEYIVEV RDPDTKEWKE VKRVPDTNAS ISGLKEGKEY
1760 1770 1780 1790 1800
QFRVRAVNKA GPGQPSEPSE KQLAKPKFIP AWLKHDNLKS ITVKAGATVR
1810 1820 1830 1840 1850
WEVKIGGEPI PEVKWFKGNQ QLENGIQLTI DTRKNEHTIL CIPSAMRSDV
1860 1870 1880 1890 1900
GEYRLTVKNS HGADEEKANL TVLDRPSKPN GPLEVSDVFE DNLNLSWKPP
1910 1920 1930 1940 1950
DDDGGEPIEY YEVEKLDTAT GRWVPCAKVK DTKAHIDGLK KGQTYQFRVK
1960 1970 1980 1990 2000
AVNKEGASDA LSTDKDTKAK NPYDEPGKTG TPDVVDWDAD RVSLEWEPPK
2010 2020 2030 2040 2050
SDGGAPITQY VIEKKGKHGR DWQECGKVSG DQTNAEILGL KEGEEYQFRV
2060 2070 2080 2090 2100
KAVNKAGPGE ASDPSRKVVA KPRNLKPWID REAMKTITIK VGNDVEFDVP
2110 2120 2130 2140 2150
VRGEPPPKKE WIFNEKPVDD QKIRIESEDY KTRFVLRGAT RKHAGLYTLT
2160 2170 2180 2190 2200
ATNASGSDKH SVEVIVLGKP SSPLGPLEVS NVYEDRADLE WKVPEDDGGA
2210 2220 2230 2240 2250
PIDHYEIEKM DLATGRWVPC GRSETTKTTV PNLQPGHEYK FRVRAVNKEG
2260 2270 2280 2290 2300
ESDPLTTNTA ILAKNPYEVP GKVDKPELVD WDKDHVDLAW NAPDDGGAPI
2310 2320 2330 2340 2350
EAFVIEKKDK NGRWEEALVV PGDQKTATVP NLKEGEEYQF RISARNKAGT
2360 2370 2380 2390 2400
GDPSDPSDRV VAKPRNLAPR IHREDLSDTT VKVGATLKFI VHIDGEPAPD
2410 2420 2430 2440 2450
VTWSFNGKGI GESKAQIENE PYISRFALPK ALRKQSGKYT ITATNINGTD
2460 2470 2480 2490 2500
SVTINIKVKS KPTKPKGPIE VTDVFEDRAT LDWKPPEDDG GEPIEFYEIE
2510 2520 2530 2540 2550
KMNTKDGIWV PCGRSGDTHF TVDSLNKGDH YKFRVKAVNS EGPSDPLETE
2560 2570 2580 2590 2600
TDILAKNPFD RPDRPGRPEP TDWDSDHVDL KWDPPLSDGG APIEEYQIEK
2610 2620 2630 2640 2650
RTKYGRWEPA ITVPGGQTTA TVPDLTPNEE YEFRVVAVNK GGPSDPSDAS
2660 2670 2680 2690 2700
KAVIAKPRNL KPHIDRDALK NLTIKAGQSI SFDVPVSGEP APTVTWHWPD
2710 2720 2730 2740 2750
NREIRNGGRV KLDNPEYQSK LVVKQMERGD SGTFTIKAVN ANGEDEATVK
2760 2770 2780 2790 2800
INVIDKPTSP NGPLDVSDVH GDHVTLNWRA PDDDGGIPIE NYVIEKYDTA
2810 2820 2830 2840 2850
SGRWVPAAKV AGDKTTAVVD GLIPGHEYKF RVAAVNAEGE SDPLETFGTT
2860 2870 2880 2890 2900
LAKDPFDKPG KTNAPEITDW DKDHVDLEWK PPANDGGAPI EEYVVEMKDE
2910 2920 2930 2940 2950
FSPFWNDVAH VPAGQTNATV GNLKEGSKYE FRIRAKNKAG LGDPSDSASA
2960 2970 2980 2990 3000
VAKARNVPPV IDRNSIQEIK VKAGQDFSLN IPVSGEPTPT ITWTFEGTPV
3010 3020 3030 3040 3050
ESDDRMKLNN EDGKTKFHVK RALRSDTGTY IIKAENENGT DTAEVKVTVL
3060 3070 3080 3090 3100
DHPSSPRGPL DVTNIVKDGC DLAWKEPEDD GGAEISHYVI EKQDAATGRW
3110 3120 3130 3140 3150
TACGESKDTN FHVDDLTQGH EYKFRVKAVN RHGDSDPLEA REAIIAKDPF
3160 3170 3180 3190 3200
DRADKPGTPE IVDWDKDHAD LKWTPPADDG GAPIEGYLVE MRTPSGDWVP
3210 3220 3230 3240 3250
AVTVGAGELT ATVDGLKPGQ TYQFRVKALN KAGESTPSDP SRTMVAKPRH
3260 3270 3280 3290 3300
LAPKINRDMF VAQRVKAGQT LNFDVNVEGE PAPKIEWFLN GSPLSSGGNT
3310 3320 3330 3340 3350
HIDNNTDNNT KLTTKSTARA DSGKYKIVAT NESGKDEHEV DVNILDIPGA
3360 3370 3380 3390 3400
PEGPLRHKDI TKESVVLKWD EPLDDGGSPI TNYVVEKQED GGRWVPCGET
3410 3420 3430 3440 3450
SDTSLKVNKL SEGHEYKFRV KAVNRQGTSA PLTSDHAIVA KNPFDEPDAP
3460 3470 3480 3490 3500
TDVTPVDWDK DHVDLEWKPP ANDGGAPIDA YIVEKKDKFG DWVECARVDG
3510 3520 3530 3540 3550
KTTKATADNL TPGETYQFRV KAVNKAGPGK PSDPTGNVVA KPRRMAPKLN
3560 3570 3580 3590 3600
LAGLLDLRIK AGTPIKLDIA FEGEPAPVAK WKANDATIDT GARADVTNTP
3610 3620 3630 3640 3650
TSSAIHIFSA VRGDTGVYKI IVENEHGKDT AQCNVTVLDV PGTPEGPLKI
3660 3670 3680 3690 3700
DEIHKEGCTL NWKPPTDNGG TDVLHYIVEK MDTSRGTWQE VGTFPDCTAK
3710 3720 3730 3740 3750
VNKLVPGKEY AFRVKAVNLQ GESKPLEAEE PIIAKNQFDV PDPVDKPEVT
3760 3770 3780 3790 3800
DWDKDRIDIK WNPTANNGGA PVTGYIVEKK EKGSAIWTEA GKTPGTTFSA
3810 3820 3830 3840 3850
DNLKPGVEYE FRVIAVNAAG PSDPSDPTDP QITKARYLKP KILTASRKIK
3860 3870 3880 3890 3900
IKAGFTHNLE VDFIGAPDPT ATWTVGDSGA ALAPELLVDA KSSTTSIFFP
3910 3920 3930 3940 3950
SAKRADSGNY KLKVKNELGE DEAIFEVIVQ DRPSAPEGPL EVSDVTKDSC
3960 3970 3980 3990 4000
VLNWKPPKDD GGAEISNYVV EKRDTKTNTW VPVSAFVTGT SITVPKLTEG
4010 4020 4030 4040 4050
HEYEFRVMAE NTFGRSDSLN TDEPVLAKDP FGTPGKPGRP EIVDTDNDHI
4060 4070 4080 4090 4100
DIKWDPPRDN GGSPVDHYDI ERKDAKTGRW IKVNTSPVQG TAFSDTRVQK
4110 4120 4130 4140 4150
GHTYEYRVVA VNKAGPGQPS DSSAAATAKP MHEAPKFDLD LDGKEFRVKA
4160 4170 4180 4190 4200
GEPLVITIPF TASPQPDISW TKEGGKPLAG VETTDSQTKL VIPSTRRSDS
4210 4220 4230 4240 4250
GPVKIKAVNP YGEAEANIKI TVIDKPGAPE NITYPAVSRH TCTLNWDAPK
4260 4270 4280 4290 4300
DDGGAEIAGY KIEYQEVGSQ IWDKVPGLIS GTAYTVRGLE HGQQYRFRIR
4310 4320 4330 4340 4350
AENAVGLSDY CQGVPVVIKD PFDPPGAPST PEITGYDTNQ VSLAWNPPRD
4360 4370 4380 4390 4400
DGGSPILGYV VERFEKRGGG DWAPVKMPMV KGTECIVPGL HENETYQFRV
4410 4420 4430 4440 4450
RAVNAAGHGE PSNGSEPVTC RPYVEKPGAP DAPRVGKITK NSAELTWNRP
4460 4470 4480 4490 4500
LRDGGAPIDG YIVEKKKLGD NDWTRCNDKP VRDTAFEVKN LGEKEEYEFR
4510 4520 4530 4540 4550
VIAVNSAGEG EPSKPSDLVL IEEQPGRPIF DINNLKDITV RAGETIQIRI
4560 4570 4580 4590 4600
PYAGGNPKPI IDLFNGNSPI FENERTVVDV NPGEIVITTT GSKRSDAGPY
4610 4620 4630 4640 4650
KISATNKYGK DTCKLNVFVL DAPGKPTGPI RATDIQADAM TLSWRPPKDN
4660 4670 4680 4690 4700
GGDAITNYVV EKRTPGGDWV TVGHPVGTTL RVRNLDANTP YEFRVRAENQ
4710 4720 4730 4740 4750
YGVGEPLETD DAIVAKNPFD TPGAPGQPEA VETSEEAITL QWTRPTSDGG
4760 4770 4780 4790 4800
APIQGYVIEK REVGSTEWTK AAFGNILDTK HRVTGLTPKK TYEFRVAAYN
4810 4820 4830 4840 4850
AAGQGEYSVN SVPITADNAP TRPKINMGML TRDILAYAGE RAKILVPFAA
4860 4870 4880 4890 4900
SPAPKVTFSK GENKISPTDP RVKVEYSDFL ATLTIEKSEL TDGGLYFVEL
4910 4920 4930 4940 4950
ENSQGSDSAS IRLKVVDKPA SPQHIRVEDI APDCCTLYWM PPSSDGGSPI
4960 4970 4980 4990 5000
TNYIVEKLDL RHSDGKWEKV SSFVRNLNYT VGGLIKDNRY RFRVRAETQY
5010 5020 5030 5040 5050
GVSEPCELAD VVVAKYQFEV PNQPEAPTVR DKDSTWAELE WDPPRDGGSK
5060 5070 5080 5090 5100
IIGYQVQYRD TSSGRWINAK MDLSEQCHAR VTGLRQNGEF EFRIIAKNAA
5110 5120 5130 5140 5150
GFSKPSPPSE RCQLKSRFGP PGPPIHVGAK SIGRNHCTIT WMAPLEDGGS
5160 5170 5180 5190 5200
KITGYNVEIR EYGSTLWTVA SDYNVREPEF TVDKLREFND YEFRVVAINA
5210 5220 5230 5240 5250
AGKGIPSLPS GPIKIQESGG SRPQIVVKPE DTAQPYNRRA VFTCEAVGRP
5260 5270 5280 5290 5300
EPTARWLRNG RELPESSRYR FEASDGVYKF TIKEVWDIDA GEYTVEVSNP
5310 5320 5330 5340 5350
YGSDTATANL VVQAPPVIEK DVPNTILPSG DLVRLKIYFS GTAPFRHSLV
5360 5370 5380 5390 5400
LNREEIDMDH PTIRIVEFDD HILITIPALS VREAGRYEYT VSNDSGEATT
5410 5420 5430 5440 5450
GFWLNVTGLP EAPQGPLHIS NIGPSTATLS WRPPVTDGGS KITSYVVEKR
5460 5470 5480 5490 5500
DLSKDEWVTV TSNVKDMNYI VTGLFENHEY EFRVSAQNEN GIGAPLVSEH
5510 5520 5530 5540 5550
PIIARLPFDP PTSPLNLEIV QVGGDYVTLS WQRPLSDGGG RLRGYIVEKQ
5560 5570 5580 5590 5600
EEEHDEWFRC NQNPSPPNNY NVPNLIDGRK YRYRVFAVND AGLSDLAELD
5610 5620 5630 5640 5650
QTLFQASGSG EGPKIVSPLS DLNEEVGRCV TFECEISGSP RPEYRWFKGC
5660 5670 5680 5690 5700
KELVDTSKYT LINKGDKQVL IINDLTSDDA DEYTCRATNS SGTRSTRANL
5710 5720 5730 5740 5750
RIKTKPRVFI PPKYHGGYEA QKGETIELKI PYKAYPQGEA RWTKDGEKIE
5760 5770 5780 5790 5800
NNSKFSITTD DKFATLRISN ASREDYGEYR VVVENSVGSD SGTVNVTVAD
5810 5820 5830 5840 5850
VPEPPRFPII ENILDEAVIL SWKPPALDGG SLVTNYTIEK REAMGGSWSP
5860 5870 5880 5890 5900
CAKSRYTYTT IEGLRAGKQY EFRIIAENKH GQSKPCEPTA PVLIPGDERK
5910 5920 5930 5940 5950
RRRGYDVDEQ GKIVRGKGTV SSNYDNYVFD IWKQYYPQPV EIKHDHVLDH
5960 5970 5980 5990 6000
YDIHEELGTG AFGVVHRVTE RATGNNFAAK FVMTPHESDK ETVRKEIQTM
6010 6020 6030 6040 6050
SVLRHPTLVN LHDAFEDDNE MVMIYEFMSG GELFEKVADE HNKMSEDEAV
6060 6070 6080 6090 6100
EYMRQVCKGL CHMHENNYVH LDLKPENIMF TTKRSNELKL IDFGLTAHLD
6110 6120 6130 6140 6150
PKQSVKVTTG TAEFAAPEVA EGKPVGYYTD MWSVGVLSYI LLSGLSPFGG
6160 6170 6180 6190 6200
ENDDETLRNV KSCDWNMDDS AFSGISEDGK DFIRKLLLAD PNTRMTIHQA
6210 6220 6230 6240 6250
LEHPWLTPGN APGRDSQIPS SRYTKIRDSI KTKYDAWPEP LPPLGRISNY
6260 6270 6280 6290 6300
SSLRKHRPQE YSIRDAFWDR SEAQPRFIVK PYGTEVGEGQ SANFYCRVIA
6310 6320 6330 6340 6350
SSPPVVTWHK DDRELKQSVK YMKRYNGNDY GLTINRVKGD DKGEYTVRAK
6360 6370 6380 6390 6400
NSYGTKEEIV FLNVTRHSEP LKFEPLEPMK KAPSPPRVEE FKERRSAPFF
6410 6420 6430 6440 6450
TFHLRNRLIQ KNHQCKLTCS LQGNPNPTIE WMKDGHPVDE DRVQVSFRSG
6460 6470 6480 6490 6500
VCSLEIFNAR VDDAGTYTVT ATNDLGVDVS ECVLTVQTKG GEPIPRVSSF
6510 6520 6530 6540 6550
RPRRAYDTLS TGTDVERSHS YADMRRRSLI RDVSPDVRSA ADDLKTKITN
6560 6570 6580 6590 6600
ELPSFTAQLS DSETEVGGSA EFSAAVSGQP EPLIEWLHNG ERISESDSRF
6610 6620 6630 6640 6650
RASYVAGKAT LRISDAKKSD EGQYLCRASN SAGQEQTRAT LTVKGDQPLL
6660 6670 6680 6690 6700
NGHAGQAVES ELRVTKHLGG EIVNNGESVT FEARVQGTPE EVLWMRNGQE
6710 6720 6730 6740 6750
LTNGDKTSIS QDGETLSFTI NSADASDAGH YQLEVRSKGT NLVSVASLVV
6760 6770 6780 6790 6800
VGEKADPPVT RLPSSVSAPL GGSTAFTIEF ENVEGLTVQW FRGSEKIEKN
6810 6820 6830 6840
ERVKSVKTGN TFKLDIKNVE QDDDGIYVAK VVKEKKAIAK YAAALLLV
Length:6,848
Mass (Da):754,514
Last modified:March 21, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i52C7B051198F7E1B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q23551UNC22_CAEEL
Twitchin
unc-22 ZK617.1
7,158Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H2FLH2H2FLH2_CAEEL
Twitchin
unc-22 CELE_ZK617.1, ZK617.1
6,927Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A061AE24A0A061AE24_CAEEL
Twitchin
unc-22 CELE_ZK617.1, ZK617.1
7,142Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A061ACT3A0A061ACT3_CAEEL
Twitchin
unc-22 CELE_ZK617.1, ZK617.1
7,133Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX284604 Genomic DNA Translation: CCF23389.1

NCBI Reference Sequences

More...
RefSeqi
NP_001255602.1, NM_001268673.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Cel.23028

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
ZK617.1g.1; ZK617.1g.1; WBGene00006759
ZK617.1g.2; ZK617.1g.2; WBGene00006759
ZK617.1g.3; ZK617.1g.3; WBGene00006759

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
178135

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA Translation: CCF23389.1
RefSeqiNP_001255602.1, NM_001268673.1
UniGeneiCel.23028

3D structure databases

ProteinModelPortaliH2FLH3
SMRiH2FLH3
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

EPDiH2FLH3
PeptideAtlasiH2FLH3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiZK617.1g.1; ZK617.1g.1; WBGene00006759
ZK617.1g.2; ZK617.1g.2; WBGene00006759
ZK617.1g.3; ZK617.1g.3; WBGene00006759
GeneIDi178135

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
178135
WormBaseiZK617.1g ; CE46868 ; WBGene00006759 ; unc-22

Phylogenomic databases

eggNOGiKOG0613 Eukaryota
ENOG410XQFD LUCA
GeneTreeiENSGT00940000169746
OrthoDBi184at2759

Enzyme and pathway databases

SignaLinkiH2FLH3

Gene expression databases

BgeeiWBGene00006759 Expressed in 4 organ(s), highest expression level in material anatomical entity
ExpressionAtlasiH2FLH3 baseline and differential

Family and domain databases

CDDicd00063 FN3, 31 hits
Gene3Di2.60.40.10, 61 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00041 fn3, 31 hits
PF07679 I-set, 27 hits
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00060 FN3, 32 hits
SM00409 IG, 30 hits
SM00408 IGc2, 24 hits
SM00220 S_TKc, 1 hit
SUPFAMiSSF48726 SSF48726, 30 hits
SSF49265 SSF49265, 17 hits
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50853 FN3, 31 hits
PS50835 IG_LIKE, 21 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH2FLH3_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H2FLH3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 21, 2012
Last sequence update: March 21, 2012
Last modified: April 10, 2019
This is version 61 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again