Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 62 (10 Apr 2019)
Sequence version 1 (21 Mar 2012)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein
Submitted name:

Twitchin

Gene

unc-22

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinaseSAAS annotation, Transferase

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
H2FLH2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
TwitchinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:unc-22Imported
ORF Names:CELE_ZK617.1Imported, ZK617.1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IV

Organism-specific databases

WormBase

More...
WormBasei
ZK617.1f ; CE46948 ; WBGene00006759 ; unc-22

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
H2FLH2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00006759 Expressed in 4 organ(s), highest expression level in material anatomical entity

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
H2FLH2 baseline and differential

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
H2FLH2

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
H2FLH2

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini5 – 97Ig-likeInterPro annotationAdd BLAST93
Domaini111 – 204Ig-likeInterPro annotationAdd BLAST94
Domaini377 – 466Ig-likeInterPro annotationAdd BLAST90
Domaini749 – 841Ig-likeInterPro annotationAdd BLAST93
Domaini891 – 982Ig-likeInterPro annotationAdd BLAST92
Domaini986 – 1075Ig-likeInterPro annotationAdd BLAST90
Domaini1081 – 1167Ig-likeInterPro annotationAdd BLAST87
Domaini1367 – 1459Fibronectin type-IIIInterPro annotationAdd BLAST93
Domaini1465 – 1560Fibronectin type-IIIInterPro annotationAdd BLAST96
Domaini1660 – 1757Fibronectin type-IIIInterPro annotationAdd BLAST98
Domaini1763 – 1856Fibronectin type-IIIInterPro annotationAdd BLAST94
Domaini1855 – 1950Ig-likeInterPro annotationAdd BLAST96
Domaini1958 – 2051Fibronectin type-IIIInterPro annotationAdd BLAST94
Domaini2057 – 2152Fibronectin type-IIIInterPro annotationAdd BLAST96
Domaini2252 – 2345Fibronectin type-IIIInterPro annotationAdd BLAST94
Domaini2348 – 2444Fibronectin type-IIIInterPro annotationAdd BLAST97
Domaini2448 – 2532Ig-likeInterPro annotationAdd BLAST85
Domaini2544 – 2637Fibronectin type-IIIInterPro annotationAdd BLAST94
Domaini2643 – 2737Fibronectin type-IIIInterPro annotationAdd BLAST95
Domaini2741 – 2831Ig-likeInterPro annotationAdd BLAST91
Domaini2839 – 2934Fibronectin type-IIIInterPro annotationAdd BLAST96
Domaini2940 – 3034Fibronectin type-IIIInterPro annotationAdd BLAST95
Domaini3037 – 3127Ig-likeInterPro annotationAdd BLAST91
Domaini3134 – 3228Fibronectin type-IIIInterPro annotationAdd BLAST95
Domaini3234 – 3328Fibronectin type-IIIInterPro annotationAdd BLAST95
Domaini3332 – 3422Ig-likeInterPro annotationAdd BLAST91
Domaini3430 – 3522Fibronectin type-IIIInterPro annotationAdd BLAST93
Domaini3528 – 3622Fibronectin type-IIIInterPro annotationAdd BLAST95
Domaini3723 – 3816Fibronectin type-IIIInterPro annotationAdd BLAST94
Domaini3822 – 3915Fibronectin type-IIIInterPro annotationAdd BLAST94
Domaini4015 – 4109Fibronectin type-IIIInterPro annotationAdd BLAST95
Domaini4115 – 4209Fibronectin type-IIIInterPro annotationAdd BLAST95
Domaini4214 – 4300Ig-likeInterPro annotationAdd BLAST87
Domaini4307 – 4400Fibronectin type-IIIInterPro annotationAdd BLAST94
Domaini4406 – 4502Fibronectin type-IIIInterPro annotationAdd BLAST97
Domaini4508 – 4603Fibronectin type-IIIInterPro annotationAdd BLAST96
Domaini4705 – 4797Fibronectin type-IIIInterPro annotationAdd BLAST93
Domaini4803 – 4898Fibronectin type-IIIInterPro annotationAdd BLAST96
Domaini5000 – 5095Fibronectin type-IIIInterPro annotationAdd BLAST96
Domaini5102 – 5196Fibronectin type-IIIInterPro annotationAdd BLAST95
Domaini5199 – 5297Fibronectin type-IIIInterPro annotationAdd BLAST99
Domaini5302 – 5390Ig-likeInterPro annotationAdd BLAST89
Domaini5492 – 5586Fibronectin type-IIIInterPro annotationAdd BLAST95
Domaini5592 – 5688Fibronectin type-IIIInterPro annotationAdd BLAST97
Domaini5692 – 5780Ig-likeInterPro annotationAdd BLAST89
Domaini5785 – 5876Ig-likeInterPro annotationAdd BLAST92
Domaini5883 – 5976Fibronectin type-IIIInterPro annotationAdd BLAST94
Domaini6030 – 6285Protein kinaseInterPro annotationAdd BLAST256
Domaini6354 – 6442Ig-likeInterPro annotationAdd BLAST89
Domaini6465 – 6564Ig-likeInterPro annotationAdd BLAST100
Domaini6632 – 6721Ig-likeInterPro annotationAdd BLAST90
Domaini6727 – 6828Ig-likeInterPro annotationAdd BLAST102
Domaini6836 – 6918Ig-likeInterPro annotationAdd BLAST83

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili473 – 500Sequence analysisAdd BLAST28

Keywords - Domaini

Coiled coilSequence analysis, RepeatSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0613 Eukaryota
ENOG410XQFD LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000169746

Database of Orthologous Groups

More...
OrthoDBi
184at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063 FN3, 31 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 61 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00041 fn3, 31 hits
PF07679 I-set, 27 hits
PF00069 Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060 FN3, 32 hits
SM00409 IG, 30 hits
SM00408 IGc2, 24 hits
SM00220 S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 30 hits
SSF49265 SSF49265, 17 hits
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853 FN3, 31 hits
PS50835 IG_LIKE, 21 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

H2FLH2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVGAPRFTQK PSIQQTPTGD LLMECHLEAD PQPTIAWQHS GNLLEPSGRV
60 70 80 90 100
VQTLTPLGGS LYKATLVIKE PNAGDGGAYK CTARNQLGES NANINLNFAG
110 120 130 140 150
AGGDEAKSRG PSFVGKPRII PKDGGALIVM ECKVKSASTP VAKWMKDGVP
160 170 180 190 200
LSMGGLYHAI FSDLGDQTYL CQLEIRGPSS SDAGQYRCNI RNDQGETNAN
210 220 230 240 250
LALNFEEPDP SERQERKRST ASPRPSSRGP GSRPSSPKKS MKSREGTPKR
260 270 280 290 300
TLKPREGSPS KKLRSRTSTP VNEEVSQSES RRSSRTDKME VDQVSGASKR
310 320 330 340 350
KPDGLPPPGG DEKKLRAGSP STRKSPSRKS ASPTPSRKGS SAGGAASGTT
360 370 380 390 400
GASASATSAT SGGSASSDAS RDKYTRPPIV LEASRSQTGR IGGSVVLEVQ
410 420 430 440 450
WQCHSSTIIE WYRDGTLVRN SSEYSQSFNG SIAKLQVNKL TEEKSGLYKC
460 470 480 490 500
HAKCDYGEGQ SSAMVKIEQS DVEEELMKHR KDAEDEYQKE EQKSQTLQAE
510 520 530 540 550
TKKRVARRSK SKSKSPAPQA KKSTTSESGR QEASEVEHKR SSSVRPDPDE
560 570 580 590 600
ESQLDEIPSS GLTIPEERRR ELLGQVGESD DEVSESISEL PSFAGGKPRR
610 620 630 640 650
KTDHHKEVEE KSTSEELKAK VAGRQVGQKR NGAQKPEEPK NLLSQIQLKK
660 670 680 690 700
VTKKAHDDTN ELEGIKLKKV TTVPKHVADD DSQSESESRR GSVFGELRRG
710 720 730 740 750
SRAPRDSADN SRRDSIRRSS IDMRRESVQE ILEKTSTPLV PSGASGSAPK
760 770 780 790 800
IVEVPENVTV VENETAILTC KVSGSPAPTF RWFKGSREVI SGGRFKHITD
810 820 830 840 850
GKEHTVALAL LKCRSQDEGP YTLTIENVHG TDSADVKLLV TSDNGLDFRA
860 870 880 890 900
MLKHRESQAG FQKDGEGGGA GGGGGEKKPM TEAERRQSLF PGKKVEKWDI
910 920 930 940 950
PLPEKTVQQQ VDKICEWKCT YSRPNAKIRW YKDRKEIFSG GLKYKIVIEK
960 970 980 990 1000
NVCTLIINNP EVDDTGKYTC EANGVPTHAQ LTVLEPPMKY SFLNPLPNTQ
1010 1020 1030 1040 1050
EIYRTKQAVL TCKVNTPRAP LVWYRGSKAI QEGDPRFIIE KDAVGRCTLT
1060 1070 1080 1090 1100
IKEVEEDDQA EWTARITQDV FSKVQVYVEE PRHTFVVPMK SQKVNESDLA
1110 1120 1130 1140 1150
TLETDVNDKD AEVVWWHDGK RIDIDGVKFK VESSNRKRRL IINGARIEDH
1160 1170 1180 1190 1200
GEYKCTTKDD RTMAQLIVDA KNKFIVALKD TEVIEKDDVT LMCQTKDTKT
1210 1220 1230 1240 1250
PGIWFRNGKQ ISSMPGGKFE TQSRNGTHTL KIGKIEMNEA DVYEIDQAGL
1260 1270 1280 1290 1300
RGSCNVTVLE AEKRPILNWK PKKIEAKAGE PCVVKVPFQI KGTRRGDPKA
1310 1320 1330 1340 1350
QILKNGKPID EEMRKLVEVI IKDDVAEIVF KNPQLADTGK WALELGNSAG
1360 1370 1380 1390 1400
TALAPFELFV KDKPKPPKGP LETKNVTAEG LDLVWGTPDP DEGAPVKAYI
1410 1420 1430 1440 1450
IEMQEGRSGN WAKVGETKGT DFKVKDLKEH GEYKFRVKAL NECGLSDPLT
1460 1470 1480 1490 1500
GESVLAKNPY GVPGKPKNMD AIDVDKDHCT LAWEPPEEDG GAPITGYIIE
1510 1520 1530 1540 1550
RREKSEKDWH QVGQTKPDCC ELTDKKVVED KEYLYRVKAV NKAGPGDPCD
1560 1570 1580 1590 1600
HGKPIKMKAK KASPEFTGGG IKDLRLKVGE TIKYDVPISG EPLPECLWVV
1610 1620 1630 1640 1650
NGKPLKAVGR VKMSSERGKH IMKIENAVRA DSGKFTITLK NSSGSCDSTA
1660 1670 1680 1690 1700
TVTVVGRPTP PKGPLDIADV CADGATLSWN PPDDDGGDPL TGYIVEAQDM
1710 1720 1730 1740 1750
DNKGKYIEVG KVDPNTTTLK VNGLRNKGNY KFRVKAVNNE GESEPLSADQ
1760 1770 1780 1790 1800
YTQIKDPWDE PGKPGRPEIT DFDADRIDIA WEPPHKDGGA PIEEYIVEVR
1810 1820 1830 1840 1850
DPDTKEWKEV KRVPDTNASI SGLKEGKEYQ FRVRAVNKAG PGQPSEPSEK
1860 1870 1880 1890 1900
QLAKPKFIPA WLKHDNLKSI TVKAGATVRW EVKIGGEPIP EVKWFKGNQQ
1910 1920 1930 1940 1950
LENGIQLTID TRKNEHTILC IPSAMRSDVG EYRLTVKNSH GADEEKANLT
1960 1970 1980 1990 2000
VLDRPSKPNG PLEVSDVFED NLNLSWKPPD DDGGEPIEYY EVEKLDTATG
2010 2020 2030 2040 2050
RWVPCAKVKD TKAHIDGLKK GQTYQFRVKA VNKEGASDAL STDKDTKAKN
2060 2070 2080 2090 2100
PYDEPGKTGT PDVVDWDADR VSLEWEPPKS DGGAPITQYV IEKKGKHGRD
2110 2120 2130 2140 2150
WQECGKVSGD QTNAEILGLK EGEEYQFRVK AVNKAGPGEA SDPSRKVVAK
2160 2170 2180 2190 2200
PRNLKPWIDR EAMKTITIKV GNDVEFDVPV RGEPPPKKEW IFNEKPVDDQ
2210 2220 2230 2240 2250
KIRIESEDYK TRFVLRGATR KHAGLYTLTA TNASGSDKHS VEVIVLGKPS
2260 2270 2280 2290 2300
SPLGPLEVSN VYEDRADLEW KVPEDDGGAP IDHYEIEKMD LATGRWVPCG
2310 2320 2330 2340 2350
RSETTKTTVP NLQPGHEYKF RVRAVNKEGE SDPLTTNTAI LAKNPYEVPG
2360 2370 2380 2390 2400
KVDKPELVDW DKDHVDLAWN APDDGGAPIE AFVIEKKDKN GRWEEALVVP
2410 2420 2430 2440 2450
GDQKTATVPN LKEGEEYQFR ISARNKAGTG DPSDPSDRVV AKPRNLAPRI
2460 2470 2480 2490 2500
HREDLSDTTV KVGATLKFIV HIDGEPAPDV TWSFNGKGIG ESKAQIENEP
2510 2520 2530 2540 2550
YISRFALPKA LRKQSGKYTI TATNINGTDS VTINIKVKSK PTKPKGPIEV
2560 2570 2580 2590 2600
TDVFEDRATL DWKPPEDDGG EPIEFYEIEK MNTKDGIWVP CGRSGDTHFT
2610 2620 2630 2640 2650
VDSLNKGDHY KFRVKAVNSE GPSDPLETET DILAKNPFDR PDRPGRPEPT
2660 2670 2680 2690 2700
DWDSDHVDLK WDPPLSDGGA PIEEYQIEKR TKYGRWEPAI TVPGGQTTAT
2710 2720 2730 2740 2750
VPDLTPNEEY EFRVVAVNKG GPSDPSDASK AVIAKPRNLK PHIDRDALKN
2760 2770 2780 2790 2800
LTIKAGQSIS FDVPVSGEPA PTVTWHWPDN REIRNGGRVK LDNPEYQSKL
2810 2820 2830 2840 2850
VVKQMERGDS GTFTIKAVNA NGEDEATVKI NVIDKPTSPN GPLDVSDVHG
2860 2870 2880 2890 2900
DHVTLNWRAP DDDGGIPIEN YVIEKYDTAS GRWVPAAKVA GDKTTAVVDG
2910 2920 2930 2940 2950
LIPGHEYKFR VAAVNAEGES DPLETFGTTL AKDPFDKPGK TNAPEITDWD
2960 2970 2980 2990 3000
KDHVDLEWKP PANDGGAPIE EYVVEMKDEF SPFWNDVAHV PAGQTNATVG
3010 3020 3030 3040 3050
NLKEGSKYEF RIRAKNKAGL GDPSDSASAV AKARNVPPVI DRNSIQEIKV
3060 3070 3080 3090 3100
KAGQDFSLNI PVSGEPTPTI TWTFEGTPVE SDDRMKLNNE DGKTKFHVKR
3110 3120 3130 3140 3150
ALRSDTGTYI IKAENENGTD TAEVKVTVLD HPSSPRGPLD VTNIVKDGCD
3160 3170 3180 3190 3200
LAWKEPEDDG GAEISHYVIE KQDAATGRWT ACGESKDTNF HVDDLTQGHE
3210 3220 3230 3240 3250
YKFRVKAVNR HGDSDPLEAR EAIIAKDPFD RADKPGTPEI VDWDKDHADL
3260 3270 3280 3290 3300
KWTPPADDGG APIEGYLVEM RTPSGDWVPA VTVGAGELTA TVDGLKPGQT
3310 3320 3330 3340 3350
YQFRVKALNK AGESTPSDPS RTMVAKPRHL APKINRDMFV AQRVKAGQTL
3360 3370 3380 3390 3400
NFDVNVEGEP APKIEWFLNG SPLSSGGNTH IDNNTDNNTK LTTKSTARAD
3410 3420 3430 3440 3450
SGKYKIVATN ESGKDEHEVD VNILDIPGAP EGPLRHKDIT KESVVLKWDE
3460 3470 3480 3490 3500
PLDDGGSPIT NYVVEKQEDG GRWVPCGETS DTSLKVNKLS EGHEYKFRVK
3510 3520 3530 3540 3550
AVNRQGTSAP LTSDHAIVAK NPFDEPDAPT DVTPVDWDKD HVDLEWKPPA
3560 3570 3580 3590 3600
NDGGAPIDAY IVEKKDKFGD WVECARVDGK TTKATADNLT PGETYQFRVK
3610 3620 3630 3640 3650
AVNKAGPGKP SDPTGNVVAK PRRMAPKLNL AGLLDLRIKA GTPIKLDIAF
3660 3670 3680 3690 3700
EGEPAPVAKW KANDATIDTG ARADVTNTPT SSAIHIFSAV RGDTGVYKII
3710 3720 3730 3740 3750
VENEHGKDTA QCNVTVLDVP GTPEGPLKID EIHKEGCTLN WKPPTDNGGT
3760 3770 3780 3790 3800
DVLHYIVEKM DTSRGTWQEV GTFPDCTAKV NKLVPGKEYA FRVKAVNLQG
3810 3820 3830 3840 3850
ESKPLEAEEP IIAKNQFDVP DPVDKPEVTD WDKDRIDIKW NPTANNGGAP
3860 3870 3880 3890 3900
VTGYIVEKKE KGSAIWTEAG KTPGTTFSAD NLKPGVEYEF RVIAVNAAGP
3910 3920 3930 3940 3950
SDPSDPTDPQ ITKARYLKPK ILTASRKIKI KAGFTHNLEV DFIGAPDPTA
3960 3970 3980 3990 4000
TWTVGDSGAA LAPELLVDAK SSTTSIFFPS AKRADSGNYK LKVKNELGED
4010 4020 4030 4040 4050
EAIFEVIVQD RPSAPEGPLE VSDVTKDSCV LNWKPPKDDG GAEISNYVVE
4060 4070 4080 4090 4100
KRDTKTNTWV PVSAFVTGTS ITVPKLTEGH EYEFRVMAEN TFGRSDSLNT
4110 4120 4130 4140 4150
DEPVLAKDPF GTPGKPGRPE IVDTDNDHID IKWDPPRDNG GSPVDHYDIE
4160 4170 4180 4190 4200
RKDAKTGRWI KVNTSPVQGT AFSDTRVQKG HTYEYRVVAV NKAGPGQPSD
4210 4220 4230 4240 4250
SSAAATAKPM HEAPKFDLDL DGKEFRVKAG EPLVITIPFT ASPQPDISWT
4260 4270 4280 4290 4300
KEGGKPLAGV ETTDSQTKLV IPSTRRSDSG PVKIKAVNPY GEAEANIKIT
4310 4320 4330 4340 4350
VIDKPGAPEN ITYPAVSRHT CTLNWDAPKD DGGAEIAGYK IEYQEVGSQI
4360 4370 4380 4390 4400
WDKVPGLISG TAYTVRGLEH GQQYRFRIRA ENAVGLSDYC QGVPVVIKDP
4410 4420 4430 4440 4450
FDPPGAPSTP EITGYDTNQV SLAWNPPRDD GGSPILGYVV ERFEKRGGGD
4460 4470 4480 4490 4500
WAPVKMPMVK GTECIVPGLH ENETYQFRVR AVNAAGHGEP SNGSEPVTCR
4510 4520 4530 4540 4550
PYVEKPGAPD APRVGKITKN SAELTWNRPL RDGGAPIDGY IVEKKKLGDN
4560 4570 4580 4590 4600
DWTRCNDKPV RDTAFEVKNL GEKEEYEFRV IAVNSAGEGE PSKPSDLVLI
4610 4620 4630 4640 4650
EEQPGRPIFD INNLKDITVR AGETIQIRIP YAGGNPKPII DLFNGNSPIF
4660 4670 4680 4690 4700
ENERTVVDVN PGEIVITTTG SKRSDAGPYK ISATNKYGKD TCKLNVFVLD
4710 4720 4730 4740 4750
APGKPTGPIR ATDIQADAMT LSWRPPKDNG GDAITNYVVE KRTPGGDWVT
4760 4770 4780 4790 4800
VGHPVGTTLR VRNLDANTPY EFRVRAENQY GVGEPLETDD AIVAKNPFDT
4810 4820 4830 4840 4850
PGAPGQPEAV ETSEEAITLQ WTRPTSDGGA PIQGYVIEKR EVGSTEWTKA
4860 4870 4880 4890 4900
AFGNILDTKH RVTGLTPKKT YEFRVAAYNA AGQGEYSVNS VPITADNAPT
4910 4920 4930 4940 4950
RPKINMGMLT RDILAYAGER AKILVPFAAS PAPKVTFSKG ENKISPTDPR
4960 4970 4980 4990 5000
VKVEYSDFLA TLTIEKSELT DGGLYFVELE NSQGSDSASI RLKVVDKPAS
5010 5020 5030 5040 5050
PQHIRVEDIA PDCCTLYWMP PSSDGGSPIT NYIVEKLDLR HSDGKWEKVS
5060 5070 5080 5090 5100
SFVRNLNYTV GGLIKDNRYR FRVRAETQYG VSEPCELADV VVAKYQFEVP
5110 5120 5130 5140 5150
NQPEAPTVRD KDSTWAELEW DPPRDGGSKI IGYQVQYRDT SSGRWINAKM
5160 5170 5180 5190 5200
DLSEQCHARV TGLRQNGEFE FRIIAKNAAG FSKPSPPSER CQLKSRFGPP
5210 5220 5230 5240 5250
GPPIHVGAKS IGRNHCTITW MAPLEDGGSK ITGYNVEIRE YGSTLWTVAS
5260 5270 5280 5290 5300
DYNVREPEFT VDKLREFNDY EFRVVAINAA GKGIPSLPSG PIKIQESGGS
5310 5320 5330 5340 5350
RPQIVVKPED TAQPYNRRAV FTCEAVGRPE PTARWLRNGR ELPESSRYRF
5360 5370 5380 5390 5400
EASDGVYKFT IKEVWDIDAG EYTVEVSNPY GSDTATANLV VQAPPVIEKD
5410 5420 5430 5440 5450
VPNTILPSGD LVRLKIYFSG TAPFRHSLVL NREEIDMDHP TIRIVEFDDH
5460 5470 5480 5490 5500
ILITIPALSV REAGRYEYTV SNDSGEATTG FWLNVTGLPE APQGPLHISN
5510 5520 5530 5540 5550
IGPSTATLSW RPPVTDGGSK ITSYVVEKRD LSKDEWVTVT SNVKDMNYIV
5560 5570 5580 5590 5600
TGLFENHEYE FRVSAQNENG IGAPLVSEHP IIARLPFDPP TSPLNLEIVQ
5610 5620 5630 5640 5650
VGGDYVTLSW QRPLSDGGGR LRGYIVEKQE EEHDEWFRCN QNPSPPNNYN
5660 5670 5680 5690 5700
VPNLIDGRKY RYRVFAVNDA GLSDLAELDQ TLFQASGSGE GPKIVSPLSD
5710 5720 5730 5740 5750
LNEEVGRCVT FECEISGSPR PEYRWFKGCK ELVDTSKYTL INKGDKQVLI
5760 5770 5780 5790 5800
INDLTSDDAD EYTCRATNSS GTRSTRANLR IKTKPRVFIP PKYHGGYEAQ
5810 5820 5830 5840 5850
KGETIELKIP YKAYPQGEAR WTKDGEKIEN NSKFSITTDD KFATLRISNA
5860 5870 5880 5890 5900
SREDYGEYRV VVENSVGSDS GTVNVTVADV PEPPRFPIIE NILDEAVILS
5910 5920 5930 5940 5950
WKPPALDGGS LVTNYTIEKR EAMGGSWSPC AKSRYTYTTI EGLRAGKQYE
5960 5970 5980 5990 6000
FRIIAENKHG QSKPCEPTAP VLIPGDERKR RRGYDVDEQG KIVRGKGTVS
6010 6020 6030 6040 6050
SNYDNYVFDI WKQYYPQPVE IKHDHVLDHY DIHEELGTGA FGVVHRVTER
6060 6070 6080 6090 6100
ATGNNFAAKF VMTPHESDKE TVRKEIQTMS VLRHPTLVNL HDAFEDDNEM
6110 6120 6130 6140 6150
VMIYEFMSGG ELFEKVADEH NKMSEDEAVE YMRQVCKGLC HMHENNYVHL
6160 6170 6180 6190 6200
DLKPENIMFT TKRSNELKLI DFGLTAHLDP KQSVKVTTGT AEFAAPEVAE
6210 6220 6230 6240 6250
GKPVGYYTDM WSVGVLSYIL LSGLSPFGGE NDDETLRNVK SCDWNMDDSA
6260 6270 6280 6290 6300
FSGISEDGKD FIRKLLLADP NTRMTIHQAL EHPWLTPGNA PGRDSQIPSS
6310 6320 6330 6340 6350
RYTKIRDSIK TKYDAWPEPL PPLGRISNYS SLRKHRPQEY SIRDAFWDRS
6360 6370 6380 6390 6400
EAQPRFIVKP YGTEVGEGQS ANFYCRVIAS SPPVVTWHKD DRELKQSVKY
6410 6420 6430 6440 6450
MKRYNGNDYG LTINRVKGDD KGEYTVRAKN SYGTKEEIVF LNVTRHSEPL
6460 6470 6480 6490 6500
KFEPLEPMKK APSPPRVEEF KERRSAPFFT FHLRNRLIQK NHQCKLTCSL
6510 6520 6530 6540 6550
QGNPNPTIEW MKDGHPVDED RVQVSFRSGV CSLEIFNARV DDAGTYTVTA
6560 6570 6580 6590 6600
TNDLGVDVSE CVLTVQTKGG EPIPRVSSFR PRRAYDTLST GTDVERSHSY
6610 6620 6630 6640 6650
ADMRRRSLIR DVSPDVRSAA DDLKTKITNE LPSFTAQLSD SETEVGGSAE
6660 6670 6680 6690 6700
FSAAVSGQPE PLIEWLHNGE RISESDSRFR ASYVAGKATL RISDAKKSDE
6710 6720 6730 6740 6750
GQYLCRASNS AGQEQTRATL TVKGDQPLLN GHAGQAVESE LRVTKHLGGE
6760 6770 6780 6790 6800
IVNNGESVTF EARVQGTPEE VLWMRNGQEL TNGDKTSISQ DGETLSFTIN
6810 6820 6830 6840 6850
SADASDAGHY QLEVRSKGTN LVSVASLVVV GEKADPPVTR LPSSVSAPLG
6860 6870 6880 6890 6900
GSTAFTIEFE NVEGLTVQWF RGSEKIEKNE RVKSVKTGNT FKLDIKNVEQ
6910 6920
DDDGIYVAKV VKEKKAIAKY AAALLLV
Length:6,927
Mass (Da):763,470
Last modified:March 21, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9671874AC5929A05
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q23551UNC22_CAEEL
Twitchin
unc-22 ZK617.1
7,158Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H2FLH3H2FLH3_CAEEL
Twitchin
unc-22 CELE_ZK617.1, ZK617.1
6,848Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A061AE24A0A061AE24_CAEEL
Twitchin
unc-22 CELE_ZK617.1, ZK617.1
7,142Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A061ACT3A0A061ACT3_CAEEL
Twitchin
unc-22 CELE_ZK617.1, ZK617.1
7,133Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX284604 Genomic DNA Translation: CCF23388.1

NCBI Reference Sequences

More...
RefSeqi
NP_001255601.1, NM_001268672.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Cel.23028

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
ZK617.1f.1; ZK617.1f.1; WBGene00006759
ZK617.1f.2; ZK617.1f.2; WBGene00006759
ZK617.1f.3; ZK617.1f.3; WBGene00006759

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
178135

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_ZK617.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA Translation: CCF23388.1
RefSeqiNP_001255601.1, NM_001268672.1
UniGeneiCel.23028

3D structure databases

ProteinModelPortaliH2FLH2
SMRiH2FLH2
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiH2FLH2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiZK617.1f.1; ZK617.1f.1; WBGene00006759
ZK617.1f.2; ZK617.1f.2; WBGene00006759
ZK617.1f.3; ZK617.1f.3; WBGene00006759
GeneIDi178135
KEGGicel:CELE_ZK617.1

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
178135
WormBaseiZK617.1f ; CE46948 ; WBGene00006759 ; unc-22

Phylogenomic databases

eggNOGiKOG0613 Eukaryota
ENOG410XQFD LUCA
GeneTreeiENSGT00940000169746
OrthoDBi184at2759

Enzyme and pathway databases

SignaLinkiH2FLH2

Gene expression databases

BgeeiWBGene00006759 Expressed in 4 organ(s), highest expression level in material anatomical entity
ExpressionAtlasiH2FLH2 baseline and differential

Family and domain databases

CDDicd00063 FN3, 31 hits
Gene3Di2.60.40.10, 61 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00041 fn3, 31 hits
PF07679 I-set, 27 hits
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00060 FN3, 32 hits
SM00409 IG, 30 hits
SM00408 IGc2, 24 hits
SM00220 S_TKc, 1 hit
SUPFAMiSSF48726 SSF48726, 30 hits
SSF49265 SSF49265, 17 hits
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50853 FN3, 31 hits
PS50835 IG_LIKE, 21 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH2FLH2_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H2FLH2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 21, 2012
Last sequence update: March 21, 2012
Last modified: April 10, 2019
This is version 62 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again