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Protein

Cellular tumor antigen p53

Gene

TP53

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivatorUniRule annotation, DNA-bindingUniRule annotation
Biological processApoptosisUniRule annotation, Cell cycleUniRule annotation, Transcription, Transcription regulationUniRule annotation
LigandMetal-bindingUniRule annotation, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Cellular tumor antigen p53UniRule annotation
Gene namesi
Name:TP53Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000141510.16

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CytoplasmUniRule annotation, NucleusUniRule annotation

PTM / Processingi

Keywords - PTMi

PhosphoproteinUniRule annotation

Expressioni

Gene expression databases

BgeeiENSG00000141510
ExpressionAtlasiH2EHT1 baseline and differential

Interactioni

Subunit structurei

Binds DNA as a homotetramer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliH2EHT1
SMRiH2EHT1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini56 – 249P53InterPro annotationAdd BLAST194
Domaini280 – 318P53_tetramerInterPro annotationAdd BLAST39

Sequence similaritiesi

Belongs to the p53 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG410IITK Eukaryota
ENOG410ZSWV LUCA

Family and domain databases

CDDicd08367 P53, 1 hit
Gene3Di2.60.40.720, 1 hit
4.10.170.10, 1 hit
InterProiView protein in InterPro
IPR008967 p53-like_TF_DNA-bd
IPR012346 p53/RUNT-type_TF_DNA-bd_sf
IPR011615 p53_DNA-bd
IPR036674 p53_tetramer_sf
IPR010991 p53_tetrameristn
IPR002117 p53_tumour_suppressor
PANTHERiPTHR11447 PTHR11447, 1 hit
PfamiView protein in Pfam
PF00870 P53, 1 hit
PF07710 P53_tetramer, 1 hit
PRINTSiPR00386 P53SUPPRESSR
SUPFAMiSSF47719 SSF47719, 1 hit
SSF49417 SSF49417, 1 hit
PROSITEiView protein in PROSITE
PS00348 P53, 1 hit

Sequencei

Sequence statusi: Complete.

H2EHT1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDLMLSPDD IEQWFTEDPG PDEAPRMPEA APPVAPAPAA PTPAAPAPAP
60 70 80 90 100
SWPLSSSVPS QKTYQGSYGF RLGFLHSGTA KSVTCTYSPA LNKMFCQLAK
110 120 130 140 150
TCPVQLWVDS TPPPGTRVRA MAIYKQSQHM TEVVRRCPHH ERCSDSDGLA
160 170 180 190 200
PPQHLIRVEG NLRVEYLDDR NTFRHSVVVP YEPPEVGSDC TTIHYNYMCN
210 220 230 240 250
SSCMGGMNRR PILTIITLED SSGNLLGRNS FEVRVCACPG RDRRTEEENL
260 270 280 290 300
RKKGEPHHEL PPGSTKRALP NNTSSSPQPK KKPLDGEYFT LQIRGRERFE
310 320 330 340 350
MFRELNEALE LKDAQAGKEP GGSRAHSSHL KSKKGQSTSR HKKLMFKTEG

PDSD
Length:354
Mass (Da):39,320
Last modified:March 21, 2012 - v1
Checksum:i6F12310423325770
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JN900492 mRNA Translation: AEX20383.1
RefSeqiNP_001119590.1, NM_001126118.1
NP_001263689.1, NM_001276760.1
NP_001263690.1, NM_001276761.1
UniGeneiHs.437460
Hs.740601

Genome annotation databases

GeneIDi7157

Similar proteinsi

Entry informationi

Entry nameiH2EHT1_HUMAN
AccessioniPrimary (citable) accession number: H2EHT1
Entry historyiIntegrated into UniProtKB/TrEMBL: March 21, 2012
Last sequence update: March 21, 2012
Last modified: May 23, 2018
This is version 49 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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