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Entry version 31 (07 Oct 2020)
Sequence version 1 (21 Mar 2012)
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Protein

Envelopment polyprotein

Gene

GP

Organism
Bovine Schmallenberg virus (isolate Bovine/BH80/Germany/2011) (SBV)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Glycoprotein C and glycoprotein N interact with each other and are present at the surface of the virion. They are able to attach the virion to a cell receptor and to promote fusion of membranes after endocytosis of the virion (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processFusion of virus membrane with host endosomal membrane, Fusion of virus membrane with host membrane, Host-virus interaction, Viral attachment to host cell, Viral penetration into host cytoplasm, Virus entry into host cell

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Envelopment polyprotein
Alternative name(s):
M polyprotein
Cleaved into the following 3 chains:
Glycoprotein NBy similarity
Short name:
Gn
Alternative name(s):
Glycoprotein G2
Non-structural protein MBy similarity
Short name:
NSm
Glycoprotein CBy similarity
Short name:
Gc
Alternative name(s):
Glycoprotein G1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GP
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBovine Schmallenberg virus (isolate Bovine/BH80/Germany/2011) (SBV)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1318464 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesRiboviriaOrthornaviraeNegarnaviricotaPolyploviricotinaEllioviricetesBunyaviralesPeribunyaviridaeOrthobunyavirusSchmallenberg orthobunyavirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiBos taurus (Bovine) [TaxID: 9913]
Ovis aries (Sheep) [TaxID: 9940]

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei210 – 230HelicalSequence analysisAdd BLAST21
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini231 – 314CytoplasmicSequence analysisAdd BLAST84
Transmembranei315 – 335HelicalSequence analysisAdd BLAST21
Topological domaini336 – 361LumenalSequence analysisAdd BLAST26
Transmembranei362 – 382HelicalSequence analysisAdd BLAST21
Topological domaini383 – 448CytoplasmicSequence analysisAdd BLAST66
Transmembranei449 – 469HelicalSequence analysisAdd BLAST21
Topological domaini470 – 1361LumenalSequence analysisAdd BLAST892
Transmembranei1362 – 1382HelicalSequence analysisAdd BLAST21
Topological domaini1383 – 1403CytoplasmicSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Host endoplasmic reticulum, Host Golgi apparatus, Host membrane, Membrane, Virion

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 17Sequence analysisAdd BLAST17
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000042247018 – 1403Envelopment polyproteinAdd BLAST1386
ChainiPRO_000042247118 – 308Glycoprotein NAdd BLAST291
ChainiPRO_0000422472309 – 466Non-structural protein MAdd BLAST158
ChainiPRO_0000422473467 – 1403Glycoprotein CAdd BLAST937

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Specific enzymatic cleavages in vivo yield mature proteins including nonstructural protein NSm, glycoprotein C, and glycoprotein N.

Keywords - PTMi

Glycoprotein

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
H2AM12

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Glycoprotein C and Glycoprotein N interact with each other.

By similarity

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11403
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
H2AM12

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005167, Bunya_G1
IPR005168, Bunya_G2
IPR026400, Bunya_nonstruc_pro_NSm

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03557, Bunya_G1, 1 hit
PF03563, Bunya_G2, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR04210, bunya_NSm, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

H2AM12-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLLNIVLISN LACLAFALPL KEGTRGSRCF LNGELVKTVN TSKVVSECCV
60 70 80 90 100
KDDISIIKSN AEHYKSGDRL AAVIKYYRLY QVKDWHSCNP IYDDHGSFMI
110 120 130 140 150
LDIDNTGTLI PKMHTCRVEC EIALNKDTGE VILNSYRINH YRISGTMHVS
160 170 180 190 200
GWFKNKIEIP LENTCESIEV TCGLKTLNFH ACFHTHKSCT RYFKGSILPE
210 220 230 240 250
LMIESFCTNL ELILLVTFIL VGSVMMMILT KTYIVYVFIP IFYPFVKLYA
260 270 280 290 300
YMYNKYFKLC KNCLLAVHPF TNCPSTCICG MIYTTTESLK LHRMCNNCSG
310 320 330 340 350
YKALPKTRKL CKSKISNIVL CVITSLIFFS FITPISSQCI DIEKLPDEYI
360 370 380 390 400
TCKRELANIK SLTIDDTYSF IYSCTCIIVL ILLKKAAKYI LYCNCSFCGM
410 420 430 440 450
VHERRGLKIM DNFTNKCLSC VCAENKGLTI HRASEKCLFK FESSYNRTGL
460 470 480 490 500
IIFMLLLVPT IVMTQETSIN CKNIQSTQLT IEHLSKCMAF YQNKTSSPVV
510 520 530 540 550
INEIISDASV DEQELIKSLN LNCNVIDRFI SESSVIETQV YYEYIKSQLC
560 570 580 590 600
PLQVHDIFTI NSASNIQWKA LARSFTLGVC NTNPHKHICR CLESMQMCTS
610 620 630 640 650
TKTDHAREMS IYYDGHPDRF EHDMKIILNI MRYIVPGLGR VLLDQIKQTK
660 670 680 690 700
DYQALRHIQG KLSPKSQSNL QLKGFLEFVD FILGANVTIE KTPQTLTTLS
710 720 730 740 750
LIKGAHRNLD QKDPGPTPIL VCKSPQKVVC YSPRGVTHPG DYISCKSKMY
760 770 780 790 800
KWPSLGVYKH NRDQQQACSS DTHCLEMFEP AERTITTKIC KVSDMTYSES
810 820 830 840 850
PYSTGIPSCN VKRFGSCNVR GHQWQIAECS NGLFYYVSAK AHSKTNDITL
860 870 880 890 900
YCLSANCLDL RYAFRSSSCS DIVWDTSYRN KLTPKSINHP DIENYIAALQ
910 920 930 940 950
SDIANDLTMH YFKPLKNLPA IIPQYKTMTL NGDKVSNGIR NSYIESHIPA
960 970 980 990 1000
INGLSAGINI AMPNGESLFS IIIYVRRVIN KASYRFLYET GPTIGINAKH
1010 1020 1030 1040 1050
EEVCTGKCPS PIPHQDGWVT FSKERSSNWG CEEWGCLAIN DGCLYGSCQD
1060 1070 1080 1090 1100
IIRPEYKIYK KSSIEQKDVE VCITMAHESF CSTVDVLQPL ISDRIQLDIQ
1110 1120 1130 1140 1150
TIQMDSMPNI IAVKNGKVYV GDINDLGSTA KKCGSVQLYS EGIIGSGTPK
1160 1170 1180 1190 1200
FDYVCHAFNR KDVILRRCFD NSYQSCLLLE QDNTLTIAST SHMEVHKKVS
1210 1220 1230 1240 1250
SVGTINYKIM LGDFDYNAYS TQATVTIDEI RCGGCYGCPE GMACALKLST
1260 1270 1280 1290 1300
NTIGSCSIKS NCDTYIKIIA VDPMQSEYSI KLNCPLATET VSVSVCSASA
1310 1320 1330 1340 1350
YTKPSISKNQ PKIVLNSLDE TSYIEQHDKK CSTWLCRVYK EGISVIFQPL
1360 1370 1380 1390 1400
FGNLSFYWRL TIYIIISLIM LILFLYILIP LCKRLKGLLE YNERIYQMEN

KFK
Length:1,403
Mass (Da):158,806
Last modified:March 21, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i90B360E3EE5BA3E5
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
JX853180 Viral cRNA Translation: AGC84161.1
HE649913 Genomic RNA Translation: CCF55030.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JX853180 Viral cRNA Translation: AGC84161.1
HE649913 Genomic RNA Translation: CCF55030.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6H3SX-ray2.02A/B465-874[»]
6H3TX-ray2.84A/B465-702[»]
6H3UX-ray3.17A/B465-702[»]
SMRiH2AM12
ModBaseiSearch...
PDBe-KBiSearch...

Proteomic databases

PRIDEiH2AM12

Family and domain databases

InterProiView protein in InterPro
IPR005167, Bunya_G1
IPR005168, Bunya_G2
IPR026400, Bunya_nonstruc_pro_NSm
PfamiView protein in Pfam
PF03557, Bunya_G1, 1 hit
PF03563, Bunya_G2, 1 hit
TIGRFAMsiTIGR04210, bunya_NSm, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGP_SBVBH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H2AM12
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2013
Last sequence update: March 21, 2012
Last modified: October 7, 2020
This is version 31 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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