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Entry version 33 (07 Oct 2020)
Sequence version 1 (21 Mar 2012)
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Protein

RNA-directed RNA polymerase L

Gene

L

Organism
Bovine Schmallenberg virus (isolate Bovine/BH80/Germany/2011) (SBV)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

RNA-dependent RNA polymerase which is responsible for replication and transcription of the viral RNA genome.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Nucleotidyltransferase, Protease, RNA-directed RNA polymerase, Thiol protease, Transferase
Biological processUbl conjugation pathway, Viral RNA replication
LigandNucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RNA-directed RNA polymerase L (EC:2.7.7.48)
Short name:
Protein L
Alternative name(s):
Large structural protein
Replicase
Transcriptase
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:L
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBovine Schmallenberg virus (isolate Bovine/BH80/Germany/2011) (SBV)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1318464 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesRiboviriaOrthornaviraeNegarnaviricotaPolyploviricotinaEllioviricetesBunyaviralesPeribunyaviridaeOrthobunyavirusSchmallenberg orthobunyavirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiBos taurus (Bovine) [TaxID: 9913]
Ovis aries (Sheep) [TaxID: 9940]

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

  • virion Source: UniProtKB-SubCell

Keywords - Cellular componenti

Virion

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004224761 – 2254RNA-directed RNA polymerase LAdd BLAST2254

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
H2AM11

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
H2AM11

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1023 – 1214RdRp catalyticPROSITE-ProRule annotationAdd BLAST192

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029124, L_protein_N
IPR007099, RNA-dir_pol_NSvirus
IPR007322, RNA_pol_bunyavir

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04196, Bunya_RdRp, 1 hit
PF15518, L_protein_N, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50525, RDRP_SSRNA_NEG_SEG, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

H2AM11-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
METYKINIFR DRINQCRSAE EAKDIVADLL MARHDYFGRE VCYYLDIEFR
60 70 80 90 100
QDVPAYDILL EFLPAGTAFN IRNCTPDNFI IHNGKLYIID YKVSTDHAYG
110 120 130 140 150
QKTYEKYTQI FGDALSELPF DFEVVIIRAD PLRDTIHVNS NQFLEIFGPL
160 170 180 190 200
NINLDFTWFF NLRSLIYEKY KDDDRFLEIV NQGEFTMTGP WIDEDTPELY
210 220 230 240 250
SHPVFLEFYD SLDEMAKLTF HESMTFDATR GEKWNQNLQK VINRYGNDYN
260 270 280 290 300
IFVKEAAAGI FRCEGNYPKP NHDEITIGWN QMVQRVSTER NLTQDVSKQK
310 320 330 340 350
PSIHFIWGQP DETSNATTPK LIKIAKALQN ISGESTYISA FRALGMLMDF
360 370 380 390 400
SENTALYEAH TSKLKSMARQ TSKRIDTKLE PIKIGTATIY WEQQFKLDTE
410 420 430 440 450
IMNTKDKSHL LKDFLGIGGH VQFSKKTIDD LDTDKPTILD FNKKEVIDFC
460 470 480 490 500
KFQYENVKKI LSGDNNLERI GCYLEEYGAN IASCSKDTWD QINQIGKSNY
510 520 530 540 550
WACIKDFSVL MKNMLAVSQY NRHNTFRVVC CANNNLFGFV MPSSDIKAKR
560 570 580 590 600
STLVYFLAVL HSTPQNVMHH GALHATFKTG SKYLSISKGM RLDKERCQRI
610 620 630 640 650
VSSPGLFMLT TLMFAGDNPT LNLTDVMNFT FHTSLSITKA MLSLTEPSRY
660 670 680 690 700
MIMNSLAISS HVRDYIAEKF GPYTKTSFSV VMANLIKRGC YMAYNQRDKV
710 720 730 740 750
DMRNICLTDY EITQKGVRDN RDLSSIWFEG YVSLKEYINQ IYLPFYFNSK
760 770 780 790 800
GLHEKHHVMI DLAKTILDIE RDQRLNIPGI WSTTPRKQTA NLNITIYAVA
810 820 830 840 850
KNLIMDTARH NYIRSRIENT NNLNRSICTI STFTSSKSCI KVGDFEKEKS
860 870 880 890 900
SATKKAADCM SKEIKKYTIA NPEFVDEELL NATIRHSRYE DLKKAIPNYI
910 920 930 940 950
DIMSTKVFDS LYQKIKRKEI DDKPTVYHIL SAMKNHTDFK FTFFNKGQKT
960 970 980 990 1000
AKDREIFVGE FEAKMCLYLV ERISKERCKL NPDEMISEPG DSKLKKLEEL
1010 1020 1030 1040 1050
AESEIRFTAA TMKQIKERYL AEMGEASHMI AYKPHSVKIE INADMSKWSA
1060 1070 1080 1090 1100
QDVLFKYFWL FALDPALYLQ EKERILYFLC NYMQKKLILP DEMLCSILDQ
1110 1120 1130 1140 1150
RIKHEDDIIY EMTNGLSQNW VNIKRNWLQG NLNYTSSYLH SCSMNVYKDI
1160 1170 1180 1190 1200
LKRAATLLEG EVLVNSMVHS DDNHTSIVMI QDKLDDDIVI EFSAKLFEKI
1210 1220 1230 1240 1250
CLTFGNQANM KKTYITNFIK EFVSLFNIYG EPFSVYGRFI LTSVGDCAFL
1260 1270 1280 1290 1300
GPYEDVASRL SATQTAIKHG APPSLAWTAI ALTQWITHST YNMLPGQIND
1310 1320 1330 1340 1350
PTSSLPSHDR FELPIELCGL INSELPTIAI AGLEADNLSY LVRLSKRMSP
1360 1370 1380 1390 1400
IHLCREPIQH QYENIHTWDI SKLTQCDIFR LKLLRYMTLD STMSSDDGMG
1410 1420 1430 1440 1450
ETSEMRSRSL LTPRKFTTAS SLSRLHSYAD YQKTIQDQQK IEELFEYFIA
1460 1470 1480 1490 1500
NPQLLVTKGE TCEEFCMSVL FRYNSRKFKE SLSIQNPAQL FIEQVLFANK
1510 1520 1530 1540 1550
PMIDYTSIHD RLFGIQDDPN INDATCIIGK KTFVETYQQI KIDVEKFTLD
1560 1570 1580 1590 1600
VEDIKTIYSF CIMNDPILVA CANNLLISIQ GVEMQRLGMT CCYMPEIKSL
1610 1620 1630 1640 1650
KVIYHSPALV LRAYVTDNYE QKGMEPDEMR RDIYHLEEFI EKTKLRTNMQ
1660 1670 1680 1690 1700
GRIANNEIKL MKRDLKFEVQ ELTKFYQICY EYVKSTEHKI KIFILPKKAY
1710 1720 1730 1740 1750
TPIDFCSLVT GNLISDNKWM VVHYLKQITV PAKKAQIATS IDLEIQIAYE
1760 1770 1780 1790 1800
CFRLIAHFAD MFLNDDSKKA YINAIINTYT YKDVQVSSLY KKIKNSRLRS
1810 1820 1830 1840 1850
KIIPLLYHLG DLQQIDVDRF DAEKAEEQIT WNNWQTSREF TTGPIDLSIK
1860 1870 1880 1890 1900
GYGRSIRIVG EDNKLTAAEM QLSRVRSDIV SRHGQALLNK PHGLKLEKME
1910 1920 1930 1940 1950
PVTDLNPKLW YIAYQLREKK RYHYGVFSTS YIEEHNSRIE ASRIRKTNKW
1960 1970 1980 1990 2000
IPVCPIAISK QSSDGKPSLA KIPMLNIGEI KFTKLQIAVD DHAMIRKAPF
2010 2020 2030 2040 2050
SKMVFFDGPP IQSGGIDIGK LMKNQNILNL RLDNIQSITL LDLCRIFSCR
2060 2070 2080 2090 2100
GSKVDQDAFE FLSDEPLDED VIDELDSSPA LVVSYTKKST KSNSFKNVIV
2110 2120 2130 2140 2150
RALIRECDIF EDIMDITDDG FTSDSNLEVL ENLTWILNML ATNQWSTELL
2160 2170 2180 2190 2200
ACIHMCLYRN EMDHIYHNFQ VPEIFVDNPI SLNVKWDEVI MFLNILRDRD
2210 2220 2230 2240 2250
YKFEPWVSIL NHSLTKAIEY AYKKMEEERK QKSTGINKFL KGKKMGGRSK

FDFQ
Length:2,254
Mass (Da):261,027
Last modified:March 21, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4FE8F8FCEC43B644
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
JX853179 Viral cRNA Translation: AGC84160.1
HE649912 Genomic RNA Translation: CCF55029.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JX853179 Viral cRNA Translation: AGC84160.1
HE649912 Genomic RNA Translation: CCF55029.1

3D structure databases

SMRiH2AM11
ModBaseiSearch...

Proteomic databases

PRIDEiH2AM11

Family and domain databases

InterProiView protein in InterPro
IPR029124, L_protein_N
IPR007099, RNA-dir_pol_NSvirus
IPR007322, RNA_pol_bunyavir
PfamiView protein in Pfam
PF04196, Bunya_RdRp, 1 hit
PF15518, L_protein_N, 1 hit
PROSITEiView protein in PROSITE
PS50525, RDRP_SSRNA_NEG_SEG, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiL_SBVBH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H2AM11
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2013
Last sequence update: March 21, 2012
Last modified: October 7, 2020
This is version 33 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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