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UniProtKB - H1A5Y8 (H1A5Y8_DANRE)

Entry version 55 (07 Apr 2021)
Sequence version 2 (20 Jan 2016)
Previous versions | rss
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Protein
Submitted name:

Leucine-rich repeat (in FLII)-interacting protein 1a

Gene

lrrfip1a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Leucine-rich repeat (in FLII)-interacting protein 1aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:lrrfip1aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Zebrafish Information Network genome database

More...ZFINi		ZDB-GENE-030131-99, lrrfip1a

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSDARG00000030012, Expressed in swim bladder and 40 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		H1A5Y8, baseline and differential

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 20DisorderedSequence analysisAdd BLAST20
Regioni52 – 122DisorderedSequence analysisAdd BLAST71
Regioni290 – 313DisorderedSequence analysisAdd BLAST24
Regioni327 – 415DisorderedSequence analysisAdd BLAST89
Regioni427 – 529DisorderedSequence analysisAdd BLAST103
Regioni956 – 987DisorderedSequence analysisAdd BLAST32
Regioni999 – 1168DisorderedSequence analysisAdd BLAST170

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili133 – 153Sequence analysisAdd BLAST21
Coiled coili161 – 199Sequence analysisAdd BLAST39
Coiled coili203 – 226Sequence analysisAdd BLAST24
Coiled coili234 – 278Sequence analysisAdd BLAST45

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi52 – 89PolyampholyteSequence analysisAdd BLAST38
Compositional biasi90 – 122PolarSequence analysisAdd BLAST33
Compositional biasi299 – 313PolarSequence analysisAdd BLAST15
Compositional biasi338 – 360PolarSequence analysisAdd BLAST23
Compositional biasi394 – 415PolyampholyteSequence analysisAdd BLAST22
Compositional biasi453 – 483PolyampholyteSequence analysisAdd BLAST31
Compositional biasi495 – 509BasicSequence analysisAdd BLAST15
Compositional biasi960 – 977AcidicSequence analysisAdd BLAST18
Compositional biasi1000 – 1014PolarSequence analysisAdd BLAST15
Compositional biasi1017 – 1049PolyampholyteSequence analysisAdd BLAST33
Compositional biasi1063 – 1077PolarSequence analysisAdd BLAST15
Compositional biasi1078 – 1092PolyampholyteSequence analysisAdd BLAST15
Compositional biasi1099 – 1115PolyampholyteSequence analysisAdd BLAST17
Compositional biasi1135 – 1168PolyampholyteSequence analysisAdd BLAST34

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the LRRFIP family.ARBA annotation

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysisARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00530000063564

Database of Orthologous Groups

More...OrthoDBi		1434475at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR019139, LRRFIP1/2

The PANTHER Classification System

More...PANTHERi		PTHR19212, PTHR19212, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF09738, LRRFIP, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All

H1A5Y8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGSQGPGRKR TPSKNGLTAE EDALNVIAKE AEARLAAKRA ARAEAREIRM 
        60         70         80         90        100
KELERQQKEV SDDEERMSVG SRSNVRADDR LERDYLEKGS SRASTISGTT 
       110        120        130        140        150
LTSLGGTSSR RGSGDTSISA DTEASIREIK DSLLEVEEKY RKAMVSNAQL 
       160        170        180        190        200
DNEKTNMMYE VDTLRDSLME LEEMLFETRR ELEEKIKDLE REKHAHSILQ 
       210        220        230        240        250
FQFSELKETL KQSEELLSDI RQLRLKQDGF VREISDLQET IEWKNKKIGA 
       260        270        280        290        300
LERQKEFSDA IRNERDELRD EVVQLKDVLK KHGIVLGPDL VTNGETGDEV 
       310        320        330        340        350
GNADPNSQTA SAEIREGSSV LGIHQLKHKD QEQKYLDDEV QGNQQSSNAL 
       360        370        380        390        400
FSSTNPPLEA NDNGVLGDSV VPGVGQHENR TEEPLSSVGD EEVTATAPKE 
       410        420        430        440        450
EVKSEEHELK DLKNNAVELK RKVCMGEHLE TEQQESKCVN SSQEIKEEAP 
       460        470        480        490        500
LDSVSNTMHD ETDKPDEAVL DEQCKEEPVE SSQMEEPPKT QVTSASNKKK 
       510        520        530        540        550
KKKKKNKQKQ KQSDKQESGT AMEVLNEDNS NQIVESVLEG TNEEPLANAV 
       560        570        580        590        600
SETTMNADLP ASSCSDITTK GQDRIEVAAT NTVVDDVHDG VQLVTDEVDS 
       610        620        630        640        650
AEISKSISNF DCSESSNDIL SEGPSNNIIS NTTDDPSNNI ICNTADDLSN 
       660        670        680        690        700
NIISDTADDL SNNIISDTAD DLSNNIISDT ADDLSNDIIT NTSVDLSSDI 
       710        720        730        740        750
ITNTPDDLSN DSITNTADDP SNIIISDPAT IIEERAEDSA NSSLEPAITC 
       760        770        780        790        800
SELKSSEMEA SCHEPSVGPI TSENNKTLLV DAKEEKVDLE CDEEPSPQNV 
       810        820        830        840        850
DVDRICDPED QEASAQFDFH VMENVENKAE LMMQEQTVDP LMDSQLQDSV 
       860        870        880        890        900
QSEVGKEKEQ GELDKENLEA HKEEVFAGSK VDYSPFIETQ VQVVQDDNLF 
       910        920        930        940        950
TNEANQESVE PSDQNSMVEK VEEEISIQGL VTPDGQLPKD DNDLLIELDV 
       960        970        980        990       1000
VGLVHKQEDA DEEDEGESFD FDETDLEVSS DGPLKKSLDK LKEEVTLLKE 
      1010       1020       1030       1040       1050
NVQEASQENQ SNVIDEDLTQ EDEHLQLADQ ESKPHEQKDD GHDTENMQSR 
      1060       1070       1080       1090       1100
DVEGCLTEKS LINCDVSPLS QQHNTSANKE DTFEEHQKAL VDVPVSERVN 
      1110       1120       1130       1140       1150
LMSDKEKREV GQEISSSIPH KKQASVISGD PKLEKEITGN NKEDESRESR 
      1160 
KSAKGKGKGK GKEDCKMS
Length:1,168
Mass (Da):129,462
Last modified:January 20, 2016 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i63C81D5C5AEAC4CE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1QGV4F1QGV4_DANRE
Leucine-rich repeat (in FLII)-inter...
lrrfip1a
1,177Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F1QDT9F1QDT9_DANRE
Leucine-rich repeat (in FLII)-inter...
lrrfip1a
487Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G1K2J1G1K2J1_DANRE
Leucine-rich repeat (in FLII)-inter...
lrrfip1a
244Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F1QI65F1QI65_DANRE
Leucine-rich repeat (in FLII)-inter...
lrrfip1a
446Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0R4IBX6A0A0R4IBX6_DANRE
Leucine-rich repeat (in FLII)-inter...
lrrfip1a
178Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0R4IL11A0A0R4IL11_DANRE
Leucine-rich repeat (in FLII)-inter...
lrrfip1a
539Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0WEN2H0WEN2_DANRE
Leucine-rich repeat (in FLII)-inter...
lrrfip1a
203Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0R4IUM2A0A0R4IUM2_DANRE
Leucine-rich repeat (in FLII)-inter...
lrrfip1a
118Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0R4IXG0A0A0R4IXG0_DANRE
Leucine-rich repeat (in FLII)-inter...
lrrfip1a
82Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
CR545476 Genomic DNA No translation available.
CT867952 Genomic DNA No translation available.

NCBI Reference Sequences

More...RefSeqi		XP_005167693.1, XM_005167636.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSDART00000101577; ENSDARP00000092350; ENSDARG00000030012

Database of genes from NCBI RefSeq genomes

More...GeneIDi		407677

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR545476 Genomic DNA No translation available.
CT867952 Genomic DNA No translation available.
RefSeqiXP_005167693.1, XM_005167636.2

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Genome annotation databases

EnsembliENSDART00000101577; ENSDARP00000092350; ENSDARG00000030012
GeneIDi407677

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		407677
ZFINiZDB-GENE-030131-99, lrrfip1a

Phylogenomic databases

GeneTreeiENSGT00530000063564
OrthoDBi1434475at2759

Gene expression databases

BgeeiENSDARG00000030012, Expressed in swim bladder and 40 other tissues
ExpressionAtlasiH1A5Y8, baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR019139, LRRFIP1/2
PANTHERiPTHR19212, PTHR19212, 1 hit
PfamiView protein in Pfam
PF09738, LRRFIP, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH1A5Y8_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H1A5Y8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: January 20, 2016
Last modified: April 7, 2021
This is version 55 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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