Fork-head domain-containing protein

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA-binding transcription factor activity Source: InterPro
• protein kinase binding Source: Ensembl
• RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: Ensembl

GO - Biological processⁱ

• DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator Source: Ensembl
• G2/M transition of mitotic cell cycle Source: Ensembl
• negative regulation of cell aging Source: Ensembl
• negative regulation of stress-activated MAPK cascade Source: Ensembl
• negative regulation of transcription by RNA polymerase II Source: Ensembl
• positive regulation of cell population proliferation Source: Ensembl
• positive regulation of double-strand break repair Source: Ensembl
• positive regulation of transcription by RNA polymerase II Source: Ensembl
• regulation of cell cycle arrest Source: Ensembl
• regulation of Ras protein signal transduction Source: Ensembl
• regulation of reactive oxygen species metabolic process Source: Ensembl

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• protein kinase binding Source: Ensembl

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MRTSPRRPLI LKRRKLALPQ NDESSTSARD EKRGQDEKAP KQEHRQEDQH 
        60         70         80         90        100
NRQPRDKRDG GLQKFPAGIK IIDHPTMPNT QVVAIPTNAD IQSIIEALTA 
       110        120        130        140        150
KGKECGNNGP NKFILISSGG TSRSAGPAPS QHLPSEKKSS AAIRAAVIQE 
       160        170        180        190        200
REKNVAQTSG LAGSGETMSS VLDNSLTNIQ WLGKMRSDGL NPSSVKEDTE 
       210        220        230        240        250
KENQIPLQER VKTEEEAAAA AIPTAAGSSS WQDSVSERPP YSYMAMIQFA 
       260        270        280        290        300
INSTERKRMT LKDIYTWIED HFPYFKHVAK PGWKNSIRHN LSLHDMFVRE 
       310        320        330        340        350
TSANGKISFW TIHPDANRCL TLDQVFKPLD LGSPTSPEYS ESQQKSNVPD 
       360        370        380        390        400
PLKNIGSKTE PQNSRRKMKP LLPRVNSYLV PIQFPLSQPL VLQPSMKVPL 
       410        420        430        440        450
SVAQGASLNS TETLQSNKRV CIAPKMSLSA EESPSLPTAV VKEEGQCDEG 
       460        470        480        490        500
LFSPSHSVQE NSSQPGEELS SFPEGACVKE EEGSQLDPWL SPFASTVTVK 
       510        520        530        540        550
EEPSLFLPDS STKERKQFTT LKSPPKAVSD SLVIKRRERR EVGRSRRKQH 
       560        570        580        590        600
LALSRSEEPV LVLPESSSFD SFRLGADRPF PQENQPLENI SQLSCSQGEE 
       610        620        630        640        650
AAFKTPVKDI FSKLPVSSTP SKVSATTTPS LEVLDPWKSA SLAKGSHELD 
       660        670        680        690        700
FSPVKTLQLP FTPLQDNQDL LGFNSTPLKN PLFDSPRELL NTESSDMVLV 
       710        720        730        740        750
PLTSSPAFIR DTSKQSAVEL AASGFTENRS LMEGLILDTM NDSLSKILLD 
       760        770 
ISFPGLEDEN LGTDISWSQL IPELK                            

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

3D structure databases

Genome annotation databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ