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Protein

Alpha-1,4 glucan phosphorylase

Gene

PYGL

Organism
Taeniopygia guttata (Zebra finch) (Poephila guttata)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.UniRule annotation

Catalytic activityi

((1->4)-alpha-D-glucosyl)(n) + phosphate = ((1->4)-alpha-D-glucosyl)(n-1) + alpha-D-glucose 1-phosphate.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferaseUniRule annotation, Transferase
Biological processCarbohydrate metabolismUniRule annotation
LigandPyridoxal phosphateUniRule annotation

Enzyme and pathway databases

ReactomeiR-TGU-6798695 Neutrophil degranulation
R-TGU-70221 Glycogen breakdown (glycogenolysis)

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-1,4 glucan phosphorylaseUniRule annotation (EC:2.4.1.1UniRule annotation)
Gene namesi
Name:PYGLImported
OrganismiTaeniopygia guttata (Zebra finch) (Poephila guttata)Imported
Taxonomic identifieri59729 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaePasseriformesPasseroideaEstrildidaeEstrildinaeTaeniopygia
Proteomesi
  • UP000007754 Componenti: Chromosome 5

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei681N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Protein-protein interaction databases

STRINGi59729.ENSTGUP00000013542

Family & Domainsi

Sequence similaritiesi

Belongs to the glycogen phosphorylase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2099 Eukaryota
COG0058 LUCA
GeneTreeiENSGT00390000016886
InParanoidiH0ZSE6
KOiK00688
OMAiARDIWNM
OrthoDBiEOG091G03RB
TreeFamiTF300309

Family and domain databases

CDDicd04300 GT1_Glycogen_Phosphorylase, 1 hit
InterProiView protein in InterPro
IPR011833 Glycg_phsphrylas
IPR000811 Glyco_trans_35
IPR035090 Pyridoxal_P_attach_site
PANTHERiPTHR11468 PTHR11468, 1 hit
PfamiView protein in Pfam
PF00343 Phosphorylase, 1 hit
PIRSFiPIRSF000460 Pprylas_GlgP, 1 hit
TIGRFAMsiTIGR02093 P_ylase, 1 hit
PROSITEiView protein in PROSITE
PS00102 PHOSPHORYLASE, 1 hit

Sequencei

Sequence statusi: Complete.

H0ZSE6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRPLSDQER RKQISIRGIV GVENVAELKR GFNRHLHFTL VKDRNVATPR
60 70 80 90 100
DYYFALAHTV RDHLVGRWIR TQQYYYEKDP KRIYYLSLEF YMGRTLQNTM
110 120 130 140 150
INLGLQNACD EAVYQLGLDM EELEEIEEDA GLGNGGLGRL AACFLDSMAT
160 170 180 190 200
LGLAAYGYGI RYEYGIFNQK IRDGWQVEEA DDWLRHGNPW EKARPEYMLP
210 220 230 240 250
VHFYGRVEHS ASGAKWIDTQ VVLALPYDTP VPGYMNNTVN TMRLWSARAP
260 270 280 290 300
NDFNLRDFNV GDYIQAVLDR NLAENISRVL YPNDNFFEGK ELRLKQEYFV
310 320 330 340 350
VAATLQDIIR RFKASKFGST DSVRTVFDSF PDQVAIQLND THPAMAIPEL
360 370 380 390 400
MRIFVDIEKL PWDKAWDITK RTFAYTNHTV LPEALERWPV DLVEMLLPRH
410 420 430 440 450
LQIIYEINQR HLDHIASLFP NDVGRLRRMS LIEEGDTKRI NMAHLCIVGS
460 470 480 490 500
HAVNGVAKIH SEIVRTQVFE DFAALEPEKF QNKTNGITPR RWLLLCNPGL
510 520 530 540 550
AELIAEKIGE DYVRDLSQLT KLHKFVDDDL FIREVAKVKQ ENKVKFALYL
560 570 580 590 600
EKEYEVKINP SSMFDVHVKR IHEYKRQLMN CLHIITMYNR IRRDPAKLFV
610 620 630 640 650
PRTVIIGGKA APGYHMGKMI IKLINAVAQV VNNDPVVGSK LKVIFLENYR
660 670 680 690 700
VSLAEKVIPA TDLSEQISTA GTEASGTGNM KFMLNGALTI GTMDGANVEM

AEEAGE
Length:706
Mass (Da):81,013
Last modified:February 22, 2012 - v1
Checksum:i202AC9C44225F780
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ABQF01004272 Genomic DNA No translation available.
ABQF01004273 Genomic DNA No translation available.
RefSeqiXP_012429438.1, XM_012573984.1

Genome annotation databases

EnsembliENSTGUT00000013696; ENSTGUP00000013542; ENSTGUG00000013142
GeneIDi101233562
KEGGitgu:101233562

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ABQF01004272 Genomic DNA No translation available.
ABQF01004273 Genomic DNA No translation available.
RefSeqiXP_012429438.1, XM_012573984.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi59729.ENSTGUP00000013542

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSTGUT00000013696; ENSTGUP00000013542; ENSTGUG00000013142
GeneIDi101233562
KEGGitgu:101233562

Organism-specific databases

CTDi5836

Phylogenomic databases

eggNOGiKOG2099 Eukaryota
COG0058 LUCA
GeneTreeiENSGT00390000016886
InParanoidiH0ZSE6
KOiK00688
OMAiARDIWNM
OrthoDBiEOG091G03RB
TreeFamiTF300309

Enzyme and pathway databases

ReactomeiR-TGU-6798695 Neutrophil degranulation
R-TGU-70221 Glycogen breakdown (glycogenolysis)

Family and domain databases

CDDicd04300 GT1_Glycogen_Phosphorylase, 1 hit
InterProiView protein in InterPro
IPR011833 Glycg_phsphrylas
IPR000811 Glyco_trans_35
IPR035090 Pyridoxal_P_attach_site
PANTHERiPTHR11468 PTHR11468, 1 hit
PfamiView protein in Pfam
PF00343 Phosphorylase, 1 hit
PIRSFiPIRSF000460 Pprylas_GlgP, 1 hit
TIGRFAMsiTIGR02093 P_ylase, 1 hit
PROSITEiView protein in PROSITE
PS00102 PHOSPHORYLASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiH0ZSE6_TAEGU
AccessioniPrimary (citable) accession number: H0ZSE6
Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: October 10, 2018
This is version 48 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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