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Protein

DNA primase large subunit

Gene

PRIM2

Organism
Taeniopygia guttata (Zebra finch) (Poephila guttata)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication.UniRule annotation

Cofactori

[4Fe-4S] clusterUniRule annotationNote: Binds 1 [4Fe-4S] cluster.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi287Iron-sulfur (4Fe-4S)UniRule annotation1
Metal bindingi367Iron-sulfur (4Fe-4S)UniRule annotation1
Metal bindingi384Iron-sulfur (4Fe-4S)UniRule annotation1
Metal bindingi424Iron-sulfur (4Fe-4S)UniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionDNA-bindingUniRule annotation, NucleotidyltransferaseUniRule annotation, Transferase
Biological processDNA replicationUniRule annotation, Transcription
Ligand4Fe-4SUniRule annotation, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

ReactomeiR-TGU-113501 Inhibition of replication initiation of damaged DNA by RB1/E2F1
R-TGU-174411 Polymerase switching on the C-strand of the telomere
R-TGU-174430 Telomere C-strand synthesis initiation
R-TGU-68952 DNA replication initiation
R-TGU-68962 Activation of the pre-replicative complex
R-TGU-69091 Polymerase switching
R-TGU-69166 Removal of the Flap Intermediate

Names & Taxonomyi

Protein namesi
Recommended name:
DNA primase large subunitUniRule annotation (EC:2.7.7.-UniRule annotation)
Gene namesi
Name:PRIM2Imported
OrganismiTaeniopygia guttata (Zebra finch) (Poephila guttata)Imported
Taxonomic identifieri59729 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaePasseriformesPasseroideaEstrildidaeEstrildinaeTaeniopygia
Proteomesi
  • UP000007754 Componenti: Chromosome 3

Subcellular locationi

    Keywords - Cellular componenti

    DNA-directed RNA polymeraseUniRule annotation, PrimosomeUniRule annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi59729.ENSTGUP00000013171

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the eukaryotic-type primase large subunit family.UniRule annotation

    Phylogenomic databases

    eggNOGiKOG2267 Eukaryota
    COG2219 LUCA
    GeneTreeiENSGT00390000009790
    InParanoidiH0ZRC8
    KOiK02685
    OMAiDCHGCPY
    OrthoDBiEOG091G08G7
    TreeFamiTF105893

    Family and domain databases

    CDDicd07322 PriL_PriS_Eukaryotic, 1 hit
    InterProiView protein in InterPro
    IPR016558 DNA_primase_lsu_euk
    IPR007238 DNA_primase_lsu_euk/arc
    PANTHERiPTHR10537 PTHR10537, 1 hit
    PfamiView protein in Pfam
    PF04104 DNA_primase_lrg, 1 hit
    PIRSFiPIRSF009449 DNA_primase_large_subunit, 1 hit

    Sequencei

    Sequence statusi: Complete.

    H0ZRC8-1 [UniParc]FASTAAdd to basket

    « Hide

            10         20         30         40         50
    MEFSSRARQR HARLAGDRRE QYPHSLQFYL EPPTESISLV EFESFAVDRL
    60 70 80 90 100
    RLLKVIENLG VSHVRGSDVY KTKLEAELRK LKFPYRALVE DDYEARRKDH
    110 120 130 140 150
    ISHFILRLAY CQSEDLRRWF LQQEMDLFRY RFNELTENLM QKFLEHVNLS
    160 170 180 190 200
    FEAIGEDLKN ELANELSVST PGFNMSKVKE QMFYKVGLAD AVDLFRARKV
    210 220 230 240 250
    FIKDGFAYVP FKEIDVIVLN HYRTKLSKAL ALTARSLPSI QSDERLQPLL
    260 270 280 290 300
    NHLSHSYVGP DYSVQNNTGK ISLEQIDALS VKSFPLCMRQ LHRALRDNHH
    310 320 330 340 350
    LRHGGRMQYG LFLKGIGLTL EQALEFWKKE FIRGKVDADK FDKGYAYSIR
    360 370 380 390 400
    HSYGKEGRRT DYTPYSCMKI IMSNPPSQGD YHGCPFRHSD PELLKQKLQS
    410 420 430 440 450
    YKISPSGIAQ VLELVKGMHF QLACQKYFEL THDVDDIGFS LNHPNQYFIE
    460 470 480 490 500
    SQKLLSGGRE PKKEFSNSGN FQQKNNSQES INSSSTPTSS NAKADTELEG

    LEAYFTED
    Length:508
    Mass (Da):58,862
    Last modified:February 22, 2012 - v1
    Checksum:i12076D1F01F0390D
    GO

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    ABQF01001019 Genomic DNA No translation available.
    ABQF01001020 Genomic DNA No translation available.
    RefSeqiXP_002194322.1, XM_002194286.2

    Genome annotation databases

    EnsembliENSTGUT00000013320; ENSTGUP00000013171; ENSTGUG00000012790
    GeneIDi100228796
    KEGGitgu:100228796

    Similar proteinsi

    Entry informationi

    Entry nameiH0ZRC8_TAEGU
    AccessioniPrimary (citable) accession number: H0ZRC8
    Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
    Last sequence update: February 22, 2012
    Last modified: March 28, 2018
    This is version 34 of the entry and version 1 of the sequence. See complete history.
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

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