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Protein

Phospholipase A2

Gene
N/A
Organism
Taeniopygia guttata (Zebra finch) (Poephila guttata)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Catalytic activityi

Phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolasePROSITE-ProRule annotation
Biological processLipid degradationPROSITE-ProRule annotation, Lipid metabolism
LigandCalciumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

ReactomeiR-TGU-1482788 Acyl chain remodelling of PC
R-TGU-1482801 Acyl chain remodelling of PS
R-TGU-1482839 Acyl chain remodelling of PE
R-TGU-1482922 Acyl chain remodelling of PI
R-TGU-1483115 Hydrolysis of LPC

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipase A2UniRule annotation (EC:3.1.1.4UniRule annotation)
OrganismiTaeniopygia guttata (Zebra finch) (Poephila guttata)Imported
Taxonomic identifieri59729 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaePasseriformesPasseroideaEstrildidaeEstrildinaeTaeniopygia
Proteomesi
  • UP000007754 Componenti: Chromosome 5

Subcellular locationi

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi59729.ENSTGUP00000011346

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 102C2InterPro annotationAdd BLAST102
Domaini248 – 788PLA2cInterPro annotationAdd BLAST541

Domaini

The N-terminal C2 domain associates with lipid membranes upon calcium binding. It modulates enzyme activity by presenting the active site to its substrate in response to elevations of cytosolic Ca2+.UniRule annotation

Phylogenomic databases

eggNOGiKOG1028 Eukaryota
KOG1325 Eukaryota
ENOG410XR72 LUCA
GeneTreeiENSGT00550000074489
InParanoidiH0ZL73
OMAiYPKYFQP
OrthoDBiEOG091G011T
TreeFamiTF325228

Family and domain databases

Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR016035 Acyl_Trfase/lysoPLipase
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR002642 LysoPLipase_cat_dom
PfamiView protein in Pfam
PF00168 C2, 1 hit
PF01735 PLA2_B, 1 hit
SMARTiView protein in SMART
SM00239 C2, 1 hit
SM00022 PLAc, 1 hit
SUPFAMiSSF52151 SSF52151, 1 hit
PROSITEiView protein in PROSITE
PS50004 C2, 1 hit
PS51210 PLA2C, 1 hit

Sequencei

Sequence statusi: Complete.

H0ZL73-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
SPCNLLTVKI IQMKNARKAD LLSQSDCYVS LSLPTASVQH FRTKTVQNSK
60 70 80 90 100
NPTWNETFHF TIQSQVKNIL ELKVCDEDKV TEDDHLLTVF FDVSKIQLGE
110 120 130 140 150
NIQLSFQLNP QGKEELEVEF TMESSPDPPE NIITNGVLVV PGHWWHGGID
160 170 180 190 200
QDQHTQPKAE RKFALTVDGS YEGTQMHTLS SCLCPTSPAR FHYIKYNQSA
210 220 230 240 250
LTVALPRRRR LSRICVQGRL LLPFFSPFFF FFSVKLVTST AISRGPSVVL
260 270 280 290 300
PRNLDARLGF DLCTDEQNFL QNRRKVVAAA LKDVLHLEED LQEHEVPIVA
310 320 330 340 350
VTTAGCGIRA LTAMYGSILG LQKLRVLDCV SYISGSSGTT WTMTKLYEDA
360 370 380 390 400
DWSRKDLGEV IIEARKQAAK CKMGAFSLKS LRNYYRELSQ RTQAGHKTSF
410 420 430 440 450
IDLWGLMIEA MLNDGKSHHR LSDQRQAVNQ GQNPLPIYLA LNVKDKVATK
460 470 480 490 500
DFREWVEFTP YEVGFLKYGA FIRAEDFGSE FFMGRLMKKL PESRICFMQG
510 520 530 540 550
MWSSIFSKNL LDAWHASDNS EDFWNRWTQD KVTEIEEQPD LPEKPYEMAT
560 570 580 590 600
CIFTPTSGLS TTLRDILTDR PAVSKYHNFL RGFQMHNEYI QDEHFTKWKD
610 620 630 640 650
TLLDTSPNDL RGNSEHLELV DAAFFFETSY PPVMRPERKV DVIIHLNYTG
660 670 680 690 700
GSQTLPLEQA CKYFAEQEIP FPCIGLMDEE NNLKECYMFD GADTPGAPLL
710 720 730 740 750
VYFPLVNDSF QRYVAPGMLR TAAEMEQGKV DISSFSSPYS TREVSLKAED
760 770 780
FNKLLKLAHY NIMNNENMIL QALRMAVARK KQALSQPS
Length:788
Mass (Da):89,884
Last modified:February 22, 2012 - v1
Checksum:iAF455261E0E15626
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ABQF01002464 Genomic DNA No translation available.
ABQF01002465 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSTGUT00000011470; ENSTGUP00000011346; ENSTGUG00000011006

Similar proteinsi

Entry informationi

Entry nameiH0ZL73_TAEGU
AccessioniPrimary (citable) accession number: H0ZL73
Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: March 28, 2018
This is version 32 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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