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Protein

Receptor protein-tyrosine kinase

Gene

EPHB3

Organism
Taeniopygia guttata (Zebra finch) (Poephila guttata)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei637ATPUniRule annotation1
Active sitei730Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi612 – 619ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, ReceptorSAAS annotation, Transferase, Tyrosine-protein kinaseSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-TGU-2682334 EPH-Ephrin signaling
R-TGU-3928662 EPHB-mediated forward signaling
R-TGU-3928664 Ephrin signaling
R-TGU-3928665 EPH-ephrin mediated repulsion of cells

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor protein-tyrosine kinaseSAAS annotation (EC:2.7.10.1SAAS annotation)
Gene namesi
Name:EPHB3Imported
OrganismiTaeniopygia guttata (Zebra finch) (Poephila guttata)Imported
Taxonomic identifieri59729 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaePasseriformesPasseroideaEstrildidaeEstrildinaeTaeniopygia
Proteomesi
  • UP000007754 Componenti: Chromosome 9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei530 – 553HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

Interactioni

Protein-protein interaction databases

STRINGi59729.ENSTGUP00000010755

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 188Eph LBDInterPro annotationAdd BLAST179
Domaini310 – 420Fibronectin type-IIIInterPro annotationAdd BLAST111
Domaini421 – 518Fibronectin type-IIIInterPro annotationAdd BLAST98
Domaini605 – 868Protein kinaseInterPro annotationAdd BLAST264
Domaini897 – 961SAMInterPro annotationAdd BLAST65

Keywords - Domaini

RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG0196 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00760000118975
InParanoidiH0ZJI7
OMAiELAWTAH
OrthoDBiEOG091G00W0
TreeFamiTF315608

Family and domain databases

CDDicd10478 EphR_LBD_B3, 1 hit
cd00063 FN3, 2 hits
Gene3Di2.60.120.260, 1 hit
2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR027936 Eph_TM
IPR034245 EphB3_rcpt_lig-bd
IPR001090 Ephrin_rcpt_lig-bd_dom
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR008979 Galactose-bd-like_sf
IPR009030 Growth_fac_rcpt_cys_sf
IPR013783 Ig-like_fold
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR011641 Tyr-kin_ephrin_A/B_rcpt-like
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
IPR016257 Tyr_kinase_ephrin_rcpt
IPR001426 Tyr_kinase_rcpt_V_CS
PfamiView protein in Pfam
PF14575 EphA2_TM, 1 hit
PF01404 Ephrin_lbd, 1 hit
PF00041 fn3, 2 hits
PF07714 Pkinase_Tyr, 1 hit
PF00536 SAM_1, 1 hit
PIRSFiPIRSF000666 TyrPK_ephrin_receptor, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00615 EPH_lbd, 1 hit
SM01411 Ephrin_rec_like, 1 hit
SM00060 FN3, 2 hits
SM00454 SAM, 1 hit
SM00219 TyrKc, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
SSF49265 SSF49265, 1 hit
SSF49785 SSF49785, 1 hit
SSF56112 SSF56112, 1 hit
SSF57184 SSF57184, 2 hits
PROSITEiView protein in PROSITE
PS51550 EPH_LBD, 1 hit
PS50853 FN3, 2 hits
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS00790 RECEPTOR_TYR_KIN_V_1, 1 hit
PS00791 RECEPTOR_TYR_KIN_V_2, 1 hit
PS50105 SAM_DOMAIN, 1 hit

Sequencei

Sequence statusi: Complete.

H0ZJI7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
LILSLLPFSP ETLMDTKWVT SELAWTTHPE TGWEEVSGYD EAMNPIRTYQ
60 70 80 90 100
VCNVREANQN NWLRTKFIQR QDVQRVYVEL KFTVRDCNSI PNIPGSCKET
110 120 130 140 150
FNLFYYESDT DSASANSPFW MENPYIKVDT IAPDESFSKL ESGRVNTKVR
160 170 180 190 200
SFGPLSKNGF YLAFQDLGAC MSLISVRAFY KKCSNTIAGF AIFPETLTGA
210 220 230 240 250
EPTSLVIAPG TCIPNAVEVS VPLKLYCNGD GEWMVPVGAC TCAAGYEPAM
260 270 280 290 300
KDTQCQACGP GTFKSKQGEG PCSPCPPNSR TTSGAAMVCT CRNGFFRADT
310 320 330 340 350
DPADSACTSV PSAPRNVISN VNETSLVLEW SEPQDTGGRD DLLYNVICKK
360 370 380 390 400
CSVERRLCTR CDDNVEFVPR QLGLTERRIY ISNLMAHTQY TFEIQAVNGI
410 420 430 440 450
SNKSPYPPHF ASVNITTNQA APSAVPTMHL HSSTGNSMTL SWTPPERPNG
460 470 480 490 500
IILDYEIKYS EKQGQSDGIA NTVTSQKNSV RLDGLKANAR YMVQVRARTV
510 520 530 540 550
AGYGRYSLPT EFQTTAEGGS TSKTFQELPL IVGSATAGLV FVIVVVVIAI
560 570 580 590 600
VCFRKQRNNT DPEYTEKLQQ YGEFTPGMKV YIDPFTYEDP NEAVREFAKE
610 620 630 640 650
IDISCVKIEE VIGAGFGEVC RGRLKLPGRR EIFVAIKTLK VGYTERQRRD
660 670 680 690 700
FLSEASIMGQ FDHPNIIHLE GVVTKSRPVM IITEFMENCA LDSFLRLNDG
710 720 730 740 750
QFTVIQLVGM MRGIAAGMKY LSEMNYVHRD LAARNILVNS NLVCKVSDFG
760 770 780 790 800
LSRFLEDDPA DPTYTSSLGG KIPIRWTAPE AIAYRKFTSA SDVWSYGIVM
810 820 830 840 850
WEVMSYGERP YWDMSNQDVI NAVEQDYRLP PPMDCPTALH QLMLDCWVRD
860 870 880 890 900
RNLRPKFAQI VNTLDKLIRN AASLKVIASV QSGISQPLLD RTVPDYTTFT
910 920 930 940 950
TVGDWLDAIK MGRYKENFVN AGFASFDLVA QMTAEDLLRI GVTLAGHQKK
960 970
ILSSIQDMRL QMNQTLPVQV
Length:970
Mass (Da):108,102
Last modified:February 22, 2012 - v1
Checksum:iDD0B8BEB5C519A6D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ABQF01023345 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSTGUT00000010868; ENSTGUP00000010755; ENSTGUG00000010386

Similar proteinsi

Entry informationi

Entry nameiH0ZJI7_TAEGU
AccessioniPrimary (citable) accession number: H0ZJI7
Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: July 18, 2018
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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