UniProtKB - H0ZGR6 (H0ZGR6_TAEGU)
Protein
Mothers against decapentaplegic homolog
Gene
SMAD3
Organism
Taeniopygia guttata (Zebra finch) (Poephila guttata)
Status
Functioni
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- regulation of transcription, DNA-templated Source: InterPro
- transforming growth factor beta receptor signaling pathway Source: InterPro
Keywordsi
Molecular function | DNA-bindingUniRule annotation |
Biological process | Transcription, Transcription regulationUniRule annotationARBA annotation |
Ligand | Metal-bindingARBA annotation, ZincARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Mothers against decapentaplegic homologUniRule annotationShort name: MAD homologUniRule annotation Short name: Mothers against DPP homologUniRule annotation Alternative name(s): SMAD family memberUniRule annotation |
Gene namesi | Name:SMAD3Imported |
Organismi | Taeniopygia guttata (Zebra finch) (Poephila guttata)Imported |
Taxonomic identifieri | 59729 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archelosauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Passeriformes › Passeroidea › Estrildidae › Estrildinae › Taeniopygia |
Proteomesi |
|
Subcellular locationi
Nucleus
- nucleus Source: UniProtKB-SubCell
Other locations
- cytoplasm Source: UniProtKB-SubCell
- transcription regulator complex Source: InterPro
Keywords - Cellular componenti
CytoplasmUniRule annotation, NucleusUniRule annotationARBA annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 10 – 136 | MH1InterPro annotationAdd BLAST | 127 | |
Domaini | 200 – 393 | MH2InterPro annotationAdd BLAST | 194 |
Sequence similaritiesi
Phylogenomic databases
GeneTreei | ENSGT00940000153499 |
HOGENOMi | CLU_026736_0_0_1 |
InParanoidi | H0ZGR6 |
OMAi | NPVSPAH |
TreeFami | TF314923 |
Family and domain databases
Gene3Di | 2.60.200.10, 1 hit 3.90.520.10, 1 hit |
InterProi | View protein in InterPro IPR013790, Dwarfin IPR003619, MAD_homology1_Dwarfin-type IPR013019, MAD_homology_MH1 IPR017855, SMAD-like_dom_sf IPR001132, SMAD_dom_Dwarfin-type IPR008984, SMAD_FHA_dom_sf IPR036578, SMAD_MH1_sf |
PANTHERi | PTHR13703, PTHR13703, 3 hits |
Pfami | View protein in Pfam PF03165, MH1, 1 hit PF03166, MH2, 1 hit |
SMARTi | View protein in SMART SM00523, DWA, 1 hit SM00524, DWB, 1 hit |
SUPFAMi | SSF49879, SSF49879, 1 hit SSF56366, SSF56366, 1 hit |
PROSITEi | View protein in PROSITE PS51075, MH1, 1 hit PS51076, MH2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
H0ZGR6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSILPFTPP IVKRLLGWKK GEQNGQEEKW CEKAVKSLVK KLKKTGQLDE
60 70 80 90 100
LEKAITTQNI NTKCITIPRS LDGRLQVSHR KGLPHVIYCR LWRWPDLHSH
110 120 130 140 150
HELRAMEMCE FAFNMKKDEV CVNPYHYQRV ETPVLPPVLV PRHTEIPAEF
160 170 180 190 200
PPLDDYSHSI PENTNFPAGI EPQSNYIPET PPPGYLSEDG ETSDHQPAFW
210 220 230 240 250
CSISYYELNQ RVGETFHASQ PSMTVDGFTD PSNSERFCLG LLSNVNRNAA
260 270 280 290 300
VELTRRHIGR GVRLYYIGGE VFAECLSDSA IFVQSPNCNQ RYGWHPATVC
310 320 330 340 350
KIPPGCNLKI FNNQEFAALL AQSVNQGFEA VYQLTRMCTI RMSFVKGWGA
360 370 380 390
EYRRQTVTST PCWIELHLNG PLQWLDKVLT QMGSPSIRCS SVS
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A674GSK0 | A0A674GSK0_TAEGU | Mothers against decapentaplegic hom... | SMAD3 | 445 | Annotation score: |
Genome annotation databases
Ensembli | ENSTGUT00000009885; ENSTGUP00000009779; ENSTGUG00000009470 |
Similar proteinsi
Cross-referencesi
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Genome annotation databases
Ensembli | ENSTGUT00000009885; ENSTGUP00000009779; ENSTGUG00000009470 |
Phylogenomic databases
GeneTreei | ENSGT00940000153499 |
HOGENOMi | CLU_026736_0_0_1 |
InParanoidi | H0ZGR6 |
OMAi | NPVSPAH |
TreeFami | TF314923 |
Family and domain databases
Gene3Di | 2.60.200.10, 1 hit 3.90.520.10, 1 hit |
InterProi | View protein in InterPro IPR013790, Dwarfin IPR003619, MAD_homology1_Dwarfin-type IPR013019, MAD_homology_MH1 IPR017855, SMAD-like_dom_sf IPR001132, SMAD_dom_Dwarfin-type IPR008984, SMAD_FHA_dom_sf IPR036578, SMAD_MH1_sf |
PANTHERi | PTHR13703, PTHR13703, 3 hits |
Pfami | View protein in Pfam PF03165, MH1, 1 hit PF03166, MH2, 1 hit |
SMARTi | View protein in SMART SM00523, DWA, 1 hit SM00524, DWB, 1 hit |
SUPFAMi | SSF49879, SSF49879, 1 hit SSF56366, SSF56366, 1 hit |
PROSITEi | View protein in PROSITE PS51075, MH1, 1 hit PS51076, MH2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | H0ZGR6_TAEGU | |
Accessioni | H0ZGR6Primary (citable) accession number: H0ZGR6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 22, 2012 |
Last sequence update: | June 17, 2020 | |
Last modified: | February 10, 2021 | |
This is version 69 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |