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Protein
Submitted name:

Platelet derived growth factor subunit A

Gene

PDGFA

Organism
Taeniopygia guttata (Zebra finch) (Poephila guttata)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGrowth factorUniRule annotationSAAS annotation

Enzyme and pathway databases

ReactomeiR-TGU-114608 Platelet degranulation
R-TGU-1257604 PIP3 activates AKT signaling
R-TGU-186763 Downstream signal transduction
R-TGU-186797 Signaling by PDGF
R-TGU-3000171 Non-integrin membrane-ECM interactions
R-TGU-5673001 RAF/MAP kinase cascade
R-TGU-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

Names & Taxonomyi

Protein namesi
Submitted name:
Platelet derived growth factor subunit AImported
Gene namesi
Name:PDGFAImported
OrganismiTaeniopygia guttata (Zebra finch) (Poephila guttata)Imported
Taxonomic identifieri59729 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaePasseriformesPasseroideaEstrildidaeEstrildinaeTaeniopygia
Proteomesi
  • UP000007754 Componenti: Chromosome 14

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi59729.ENSTGUP00000008778

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 137PDGF_2InterPro annotationAdd BLAST102

Sequence similaritiesi

Belongs to the PDGF/VEGF growth factor family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG410IEXJ Eukaryota
ENOG4111GMH LUCA
GeneTreeiENSGT00510000046755
InParanoidiH0ZDW6
OMAiMRTWACL
OrthoDBiEOG091G0LNU
TreeFamiTF319554

Family and domain databases

CDDicd00135 PDGF, 1 hit
Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR023581 PD_growth_factor_CS
IPR000072 PDGF/VEGF_dom
IPR006782 PDGF_N
PfamiView protein in Pfam
PF00341 PDGF, 1 hit
PF04692 PDGF_N, 1 hit
SMARTiView protein in SMART
SM00141 PDGF, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00249 PDGF_1, 1 hit
PS50278 PDGF_2, 1 hit

Sequencei

Sequence statusi: Complete.

H0ZDW6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
ILFPVLGYDD VSETNLRSYS VHSAKHVQEN RPVPIRRKRS IEEAIPAVCK
60 70 80 90 100
TRTVIYEIPR SQIDPTSANF LIWPPCVEVK RCTGCCNTSS VKCQPSRIHH
110 120 130 140
RSVKVAKVEY VRKKPKLKEV LVRLEEHMEC TCTSSNTNSD YREEET
Length:146
Mass (Da):16,801
Last modified:February 22, 2012 - v1
Checksum:iBA97AC307C41FBA3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ABQF01038289 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSTGUT00000008871; ENSTGUP00000008778; ENSTGUG00000008526

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ABQF01038289 Genomic DNA No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi59729.ENSTGUP00000008778

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSTGUT00000008871; ENSTGUP00000008778; ENSTGUG00000008526

Phylogenomic databases

eggNOGiENOG410IEXJ Eukaryota
ENOG4111GMH LUCA
GeneTreeiENSGT00510000046755
InParanoidiH0ZDW6
OMAiMRTWACL
OrthoDBiEOG091G0LNU
TreeFamiTF319554

Enzyme and pathway databases

ReactomeiR-TGU-114608 Platelet degranulation
R-TGU-1257604 PIP3 activates AKT signaling
R-TGU-186763 Downstream signal transduction
R-TGU-186797 Signaling by PDGF
R-TGU-3000171 Non-integrin membrane-ECM interactions
R-TGU-5673001 RAF/MAP kinase cascade
R-TGU-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

Family and domain databases

CDDicd00135 PDGF, 1 hit
Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR023581 PD_growth_factor_CS
IPR000072 PDGF/VEGF_dom
IPR006782 PDGF_N
PfamiView protein in Pfam
PF00341 PDGF, 1 hit
PF04692 PDGF_N, 1 hit
SMARTiView protein in SMART
SM00141 PDGF, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00249 PDGF_1, 1 hit
PS50278 PDGF_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiH0ZDW6_TAEGU
AccessioniPrimary (citable) accession number: H0ZDW6
Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: May 23, 2018
This is version 50 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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