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Protein

GMP reductase

Gene

GMPR

Organism
Taeniopygia guttata (Zebra finch) (Poephila guttata)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.UniRule annotation

Catalytic activityi

Inosine 5'-phosphate + NH3 + NADP+ = guanosine 5'-phosphate + NADPH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei78NADPUniRule annotation1
Metal bindingi181Potassium; via carbonyl oxygenUniRule annotation1
Metal bindingi183Potassium; via carbonyl oxygenUniRule annotation1
Active sitei186Thioimidate intermediateUniRule annotation1
Metal bindingi186Potassium; via carbonyl oxygenUniRule annotation1
Active sitei188Proton donor/acceptorUniRule annotation1
Metal bindingi189PotassiumUniRule annotation1
Binding sitei269NADP; via carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi26 – 27NADP; shared with neighboring subunitUniRule annotation2
Nucleotide bindingi129 – 131NADPUniRule annotation3
Nucleotide bindingi180 – 181NADPUniRule annotation2
Nucleotide bindingi285 – 286NADPUniRule annotation2
Nucleotide bindingi314 – 317NADP; shared with neighboring subunitUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processPurine metabolismUniRule annotation
LigandMetal-bindingUniRule annotation, NADPUniRule annotation, PotassiumUniRule annotation

Enzyme and pathway databases

ReactomeiR-TGU-74217 Purine salvage

Names & Taxonomyi

Protein namesi
Recommended name:
GMP reductaseUniRule annotation (EC:1.7.1.7UniRule annotation)
Short name:
GMPRUniRule annotation
Alternative name(s):
Guanosine 5'-monophosphate oxidoreductaseUniRule annotation
Short name:
Guanosine monophosphate reductaseUniRule annotation
Gene namesi
Name:GMPRUniRule annotationImported
OrganismiTaeniopygia guttata (Zebra finch) (Poephila guttata)Imported
Taxonomic identifieri59729 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaePasseriformesPasseroideaEstrildidaeEstrildinaeTaeniopygia
Proteomesi
  • UP000007754 Componenti: Chromosome 2

Subcellular locationi

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi59729.ENSTGUP00000006186

Structurei

3D structure databases

ProteinModelPortaliH0Z6I8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 339IMPDHInterPro annotationAdd BLAST330

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni219 – 221GMP bindingUniRule annotation3
Regioni242 – 243GMP bindingUniRule annotation2
Regioni268 – 270GMP bindingUniRule annotation3
Regioni286 – 290GMP bindingUniRule annotation5

Sequence similaritiesi

Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG2550 Eukaryota
COG0516 LUCA
GeneTreeiENSGT00530000062923
InParanoidiH0Z6I8
KOiK00364
OMAiGSHCTTR
OrthoDBiEOG091G09KQ
TreeFamiTF300378

Family and domain databases

CDDicd00381 IMPDH, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00596 GMP_reduct_type1, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR005993 GMPR
IPR015875 IMP_DH/GMP_Rdtase_CS
IPR001093 IMP_DH_GMPRt
PfamiView protein in Pfam
PF00478 IMPDH, 1 hit
PIRSFiPIRSF000235 GMP_reductase, 1 hit
TIGRFAMsiTIGR01305 GMP_reduct_1, 1 hit
PROSITEiView protein in PROSITE
PS00487 IMP_DH_GMP_RED, 1 hit

Sequencei

Sequence statusi: Complete.

H0Z6I8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRVDADLKL DFKDVLVRPK RSSLKSRAEV DLTRTFTFRN SKQTYTGIPI
60 70 80 90 100
IVANMDTVGT FEMAVVMAKH AMFTAIHKHY SLEEWKLFAA NHPECLEHVA
110 120 130 140 150
ASSGSGQNDL KKLTSILEAI PAIKYICLDV ANGYSEHFVE FVKSVRALFP
160 170 180 190 200
HHTIMAGNVV TGEMVEELII SGADIIKVGI GPGSVCTTRI KTGVGYPQLS
210 220 230 240 250
AVIECADSAH GLKGHIISDG GCSCPGDVAK AFGAGADFVM IGGMFAGHDQ
260 270 280 290 300
SAGDIIERNG KKVKLFYGMS SDTAMKKHAG GVAEYRASEG KTVEVPYKGD
310 320 330 340
VEHTILDILG GLRSTCTYVG AAKLKELSKR TTFIRVTQQH NEVFS
Length:345
Mass (Da):37,286
Last modified:February 22, 2012 - v1
Checksum:i70A78FA0A37540F2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ABQF01024106 Genomic DNA No translation available.
ABQF01024107 Genomic DNA No translation available.
RefSeqiXP_002188093.2, XM_002188057.3

Genome annotation databases

EnsembliENSTGUT00000006247; ENSTGUP00000006186; ENSTGUG00000005990
GeneIDi100228013
KEGGitgu:100228013

Similar proteinsi

Entry informationi

Entry nameiH0Z6I8_TAEGU
AccessioniPrimary (citable) accession number: H0Z6I8
Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: March 28, 2018
This is version 44 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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