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Entry version 58 (31 Jul 2019)
Sequence version 1 (22 Feb 2012)
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Protein
Submitted name:

Ankyrin 1

Gene

ANK1

Organism
Taeniopygia guttata (Zebra finch) (Poephila guttata)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Ankyrin 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ANK1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiTaeniopygia guttata (Zebra finch) (Poephila guttata)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri59729 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaePasseriformesPasseroideaEstrildidaeEstrildinaeTaeniopygia
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007754 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini3 – 778ANK_REP_REGIONInterPro annotationAdd BLAST776
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati36 – 57ANKPROSITE-ProRule annotationAdd BLAST22
Repeati69 – 101ANKPROSITE-ProRule annotationAdd BLAST33
Repeati102 – 134ANKPROSITE-ProRule annotationAdd BLAST33
Repeati135 – 159ANKPROSITE-ProRule annotationAdd BLAST25
Repeati197 – 229ANKPROSITE-ProRule annotationAdd BLAST33
Repeati230 – 262ANKPROSITE-ProRule annotationAdd BLAST33
Repeati263 – 295ANKPROSITE-ProRule annotationAdd BLAST33
Repeati296 – 328ANKPROSITE-ProRule annotationAdd BLAST33
Repeati329 – 361ANKPROSITE-ProRule annotationAdd BLAST33
Repeati362 – 394ANKPROSITE-ProRule annotationAdd BLAST33
Repeati395 – 427ANKPROSITE-ProRule annotationAdd BLAST33
Repeati428 – 460ANKPROSITE-ProRule annotationAdd BLAST33
Repeati461 – 493ANKPROSITE-ProRule annotationAdd BLAST33
Repeati494 – 526ANKPROSITE-ProRule annotationAdd BLAST33
Repeati527 – 559ANKPROSITE-ProRule annotationAdd BLAST33
Repeati560 – 586ANKPROSITE-ProRule annotationAdd BLAST27
Repeati593 – 625ANKPROSITE-ProRule annotationAdd BLAST33
Repeati626 – 658ANKPROSITE-ProRule annotationAdd BLAST33
Repeati659 – 691ANKPROSITE-ProRule annotationAdd BLAST33
Repeati692 – 724ANKPROSITE-ProRule annotationAdd BLAST33
Repeati725 – 757ANKPROSITE-ProRule annotationAdd BLAST33
Domaini904 – 1059ZU5InterPro annotationAdd BLAST156
Domaini1061 – 1207ZU5InterPro annotationAdd BLAST147
Domaini1396 – 1480DeathInterPro annotationAdd BLAST85

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni861 – 895DisorderedSequence analysisAdd BLAST35
Regioni1632 – 1654DisorderedSequence analysisAdd BLAST23

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

ANK repeatPROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4177 Eukaryota
COG0666 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155760

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
H0Z4N4

Identification of Orthologs from Complete Genome Data

More...
OMAi
DRADMKM

TreeFam database of animal gene trees

More...
TreeFami
TF351263

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR040745 Ankyrin_UPA
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
IPR000906 ZU5_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796 Ank_2, 9 hits
PF00531 Death, 1 hit
PF17809 UPA_2, 1 hit
PF00791 ZU5, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01415 ANKYRIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248 ANK, 23 hits
SM00005 DEATH, 1 hit
SM00218 ZU5, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47986 SSF47986, 1 hit
SSF48403 SSF48403, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 21 hits
PS50017 DEATH_DOMAIN, 1 hit
PS51145 ZU5, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

H0Z4N4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
KADAATSFLR AARSGNLDKA LDHLRNGVDI NTCNQNGLNA LHLASKEGHV
60 70 80 90 100
KMVVELLHKE IVLETTTKKG NTALHIAALA GQQDVVRELV NYGANVNAQS
110 120 130 140 150
QKGFTPLYMA AQENHLEVVK FLLENGANQN VATEDGFTPL AVALQQGHEN
160 170 180 190 200
VVAHLINYGT KGKVRLPALH IAARNDDTRT AAVLLQNDPN ADVLSKTGFT
210 220 230 240 250
PLHIAAHYEN LSVAQLLLNR GASVNFTPQN GITPLHIASR RGNIIMVRLL
260 270 280 290 300
LDRGAQIETR TKDELTPLHC AARNGHVRIA EILLDHGAPI QAKTKNGLSP
310 320 330 340 350
IHMAAQGDHL DCVRLLLQYS AEIDDITLDH LTPLHVAAHC GHHRVAKLLV
360 370 380 390 400
EKGAKPNSRA LNGFTPLHIA CKKNHIRVME LLLKTGASID AVTESGLTPL
410 420 430 440 450
HVAAFMGHLP IVKTLLQRGA SPNVSNVKVE TPLHMAARAG HTDVAKYLLQ
460 470 480 490 500
NKAKANAKAK DDQTPLHCAA RIGHTGMVKL LLENNANPNL ATTAGHTPLH
510 520 530 540 550
ITAREGHMDT ALALLEKGAS QTCMTKKGFT PLHVAAKYGK VDVAELLLAH
560 570 580 590 600
DAHLNAAGKN GLTPLHVAVH HNNLEIVKLL LPKGSSPHNS AWNGYTPLHI
610 620 630 640 650
AAKQNQMEVA SSLLQYGASA NAESLQGVTP LHLASQEGHA DMVALLFSKQ
660 670 680 690 700
ANGNLGNKSG LTPLHLVAQE GHVLVADVLV KHGVTVDATT RMGYTPLHVA
710 720 730 740 750
SHYGNIKLVK FLLQHQADVN AKTKLGYTPL HQAAQQGHTD VVTLLLKHGA
760 770 780 790 800
SPNEISTNGT TPLAIAKRLG YISVTDVLKI VTEETDIPAV GDKHRMSFPE
810 820 830 840 850
TVDEILDVSE DEGEGWEGQC GRQQSRGWHW CSCWKRDTPR PGDLVESPAV
860 870 880 890 900
LQVPCVPPET VVTRAEETEQ PSKEFDEDSL IPSSPATETS DNISPVASPV
910 920 930 940 950
HTGFLVSFMV DARGGSMRGS RHHGLRVVIP PRACAAPTRI TCRLVKPQKL
960 970 980 990 1000
PAPPPLAEEE GLGSRIIALG PAGAQFLSPV IVEIPHFASY GRGDRELVVL
1010 1020 1030 1040 1050
RSENGSVWKE HRNRYEESYM DQLLNGMDEE LESQEELDKK RVCRIITTDF
1060 1070 1080 1090 1100
PLYFVVMSRI CQDCDMIGPE GGCLKSTLVP MVQATFPDTA VTKRVRLALQ
1110 1120 1130 1140 1150
AQPVPDELVT KLLGNQATFS PIVTVEPRRR KFHRPIGLRI PLPPSWKDNP
1160 1170 1180 1190 1200
RDSGEGDTTS LRLLCSVIGG TAQAQWEDIT GTTKLIYENE CANFTTNVSA
1210 1220 1230 1240 1250
RFWLADCPRT AEAVHFATML YKELTAVPYM AKFVVFAKMN DAREGRLRCY
1260 1270 1280 1290 1300
CMTDDKVDKT LEQHENFTEV ARSRDIEVVE GMPLHVELSG NLVPVKKAAQ
1310 1320 1330 1340 1350
PRTFLFQSFR ENRLVIPIKV RDSSREASGS LSFLRKAMKY EDLQHVLCHL
1360 1370 1380 1390 1400
NISIPPCTKG SGSDERRRTL TPLSLRERYS ILSETSFGSL SSTDKADQKM
1410 1420 1430 1440 1450
VDIAEQLGLS WAELARELQF GVDDINRIRV ENPNSLLEQS IALLNLWASR
1460 1470 1480 1490 1500
EGKNFKIENL YTALRNIDRS EIVNMLEGSG RQSRSLKGSW RYTDRDYSLS
1510 1520 1530 1540 1550
PSQMNGYASL QDELLSPASL HYTLPSPLRA DQYWNEVAIM DAIPMAATEQ
1560 1570 1580 1590 1600
DALMEMSDMQ VWSSGLTPSL VTAEDSSLEC SKAEDSDATS EGRFPGQLLA
1610 1620 1630 1640 1650
DAHGPDHMGS MDLVEDDTVD SDAMNGMIDL LEQEEGQRPE GKMPSGTGEQ
1660 1670 1680 1690 1700
DPESEVSFVS VQEKVQARIM TSPTFSHDVE KSADRLRDWN AEGSFISCLQ
1710 1720 1730 1740 1750
DLTAGSWQEG VTRRLLPTHS TASGAQGQEQ EQVLLCRGQR LAASAPHRRL
1760 1770 1780 1790 1800
AGGGQQPLLW AGESALQEVQ GKEDIHLPGE QVTEQQFTDQ GNIVTKKIIR
1810 1820 1830 1840 1850
KVVRQLGPGD MGDRQEQEEL ILEGSQDLEA EDDHFMKYSI LHRDVRVPKP
1860 1870
EVSGGRMGAQ IVKRASLKRG KQ
Length:1,872
Mass (Da):205,131
Last modified:February 22, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i141B9C15311A8C96
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
ABQF01056193 Genomic DNA No translation available.
ABQF01056194 Genomic DNA No translation available.
ABQF01056195 Genomic DNA No translation available.
ABQF01056196 Genomic DNA No translation available.
ABQF01056197 Genomic DNA No translation available.
ABQF01056198 Genomic DNA No translation available.
ABQF01056199 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSTGUT00000005583; ENSTGUP00000005529; ENSTGUG00000005264

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ABQF01056193 Genomic DNA No translation available.
ABQF01056194 Genomic DNA No translation available.
ABQF01056195 Genomic DNA No translation available.
ABQF01056196 Genomic DNA No translation available.
ABQF01056197 Genomic DNA No translation available.
ABQF01056198 Genomic DNA No translation available.
ABQF01056199 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSTGUT00000005583; ENSTGUP00000005529; ENSTGUG00000005264

Phylogenomic databases

eggNOGiKOG4177 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00940000155760
InParanoidiH0Z4N4
OMAiDRADMKM
TreeFamiTF351263

Family and domain databases

Gene3Di1.25.40.20, 3 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR040745 Ankyrin_UPA
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
IPR000906 ZU5_dom
PfamiView protein in Pfam
PF12796 Ank_2, 9 hits
PF00531 Death, 1 hit
PF17809 UPA_2, 1 hit
PF00791 ZU5, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 23 hits
SM00005 DEATH, 1 hit
SM00218 ZU5, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
SSF48403 SSF48403, 2 hits
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 21 hits
PS50017 DEATH_DOMAIN, 1 hit
PS51145 ZU5, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH0Z4N4_TAEGU
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H0Z4N4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: July 31, 2019
This is version 58 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
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