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UniProtKB - H0YZZ8 (H0YZZ8_TAEGU)

Entry version 54 (07 Oct 2020)
Sequence version 2 (17 Jun 2020)
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Protein

PINc domain-containing protein

Gene

SMG5

Organism
Taeniopygia guttata (Zebra finch) (Poephila guttata)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processNonsense-mediated mRNA decayARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
PINc domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SMG5Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiTaeniopygia guttata (Zebra finch) (Poephila guttata)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri59729 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archelosauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Passeriformes › Passeroidea › Estrildidae › Estrildinae › Taeniopygia
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007754 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 25

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

CytoplasmARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini888 – 1011PINcInterPro annotationAdd BLAST124

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni410 – 429DisorderedSequence analysisAdd BLAST20
Regioni464 – 584DisorderedSequence analysisAdd BLAST121
Regioni623 – 669DisorderedSequence analysisAdd BLAST47

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili847 – 874Sequence analysisAdd BLAST28
Coiled coili925 – 945Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi483 – 498PolarSequence analysisAdd BLAST16
Compositional biasi560 – 574PolarSequence analysisAdd BLAST15

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154566

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_011872_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		H0YZZ8

Identification of Orthologs from Complete Genome Data

More...OMAi		VRTKKCI

TreeFam database of animal gene trees

More...TreeFami		TF327119

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR018834, DNA/RNA-bd_Est1-type
IPR019458, EST1
IPR002716, PIN_dom
IPR011990, TPR-like_helical_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF10374, EST1, 1 hit
PF10373, EST1_DNA_bind, 2 hits
PF13638, PIN_4, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00670, PINc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48452, SSF48452, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

H0YZZ8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSQGGGAAGE SGEPEAKVLH TKRLYRAVVE AVHRLDLILG NKAAYQDVFK 
        60         70         80         90        100
PENISLRNKL RELCVKLMFL HPVDYGRKAE ELLWRKVYYE VIQLIKTNKK 
       110        120        130        140        150
HIHSRSTLEC AYRTHLVAGI GFYQHLLLYI QSHYQLELQC CIDWTHVTDP 
       160        170        180        190        200
LIGCKKPVSA SEKEMEWAQM ACHRCLVYLG DLARYQNELA GVDTELLAER 
       210        220        230        240        250
FYYQALSVAP QVGMPFNQLG TLAGSKYYNV EATYCYLRCI QSEVSFEGAY 
       260        270        280        290        300
GNLKRLYDKA AKMYHQLKKC ETRKLSPSKK RGKDIKRLLV SFMYLQSLLQ 
       310        320        330        340        350
PKSSSLDSEL TSLCQSVLED FNLCLFYLPS PPNLSSTSED EEEYESGYSF 
       360        370        380        390        400
LPDLLIFRMV IICLMSVHSL KRAGSKQYSA AIAFTLALFS HLINHVNIRL 
       410        420        430        440        450
QAELEEGENP VPAFQSDGTD EQEPREAVNS IEKEAEAELA NHQPSEEQRK 
       460        470        480        490        500
NDCKKSKKYS RLSCLRRRRH PQKVDESDLS EGFDSDSSQS SIKGSDGSES 
       510        520        530        540        550
GSEKSDEEAE AAFDVETDSD MNSQESRSDL EDMEDEPGEE GSSQGKSGPK 
       560        570        580        590        600
EALKNCVDSS GLRDSKSPSI SKTEAVDPAV NGPASLSTND ASIASNLQAM 
       610        620        630        640        650
STQLFQTKRC FRLAPTFSNI LLKPSSDPPA LKGGIESKPC VNGDLEKPSL 
       660        670        680        690        700
AEQDDVSDSE ESISSNKSCR NERSLQEKLE IVTNEGLLLT VKVFLDWLRT 
       710        720        730        740        750
NTDLIIMCAQ SSQSLWNRLS VLLNLLPSAA DLQESGLALC DEVKDILSDA 
       760        770        780        790        800
ELPDLKANLL LPEDVALRNL PPLKNAHKRF NFEQDRPIFS AVEESVVRIC 
       810        820        830        840        850
CIRSFGHFIT HLQGSILQFN SELGIFISIA QSEQDNLLHQ AQAQFHMAAE 
       860        870        880        890        900
EARRNRLMRD MAQLRLQLEV SQLEGSLQQP KAQSAMSPYL VPDTQALCQH 
       910        920        930        940        950
LALVKQLATS GRFIIIIPRT VIDGLDFLKK ENAGARDSIR YLEAEFKKGN 
       960        970        980        990       1000
RYIRCQKDVG KSFERHKLKR QDLDAWNLYK ILDSCKQLTV SQGSGEDDTT 
      1010       1020       1030       1040 
GMVTIITGFQ LEDPSSFSLP MQSAIQAAAN ASIEIKNVLE FYKQWKEMG
Length:1,049
Mass (Da):117,684
Last modified:June 17, 2020 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBFF6BEBB3F39B8A4
GO

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSTGUT00000003925; ENSTGUP00000003883; ENSTGUG00000003748

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Genome annotation databases

EnsembliENSTGUT00000003925; ENSTGUP00000003883; ENSTGUG00000003748

Phylogenomic databases

GeneTreeiENSGT00940000154566
HOGENOMiCLU_011872_0_0_1
InParanoidiH0YZZ8
OMAiVRTKKCI
TreeFamiTF327119

Family and domain databases

InterProiView protein in InterPro
IPR018834, DNA/RNA-bd_Est1-type
IPR019458, EST1
IPR002716, PIN_dom
IPR011990, TPR-like_helical_dom_sf
PfamiView protein in Pfam
PF10374, EST1, 1 hit
PF10373, EST1_DNA_bind, 2 hits
PF13638, PIN_4, 1 hit
SMARTiView protein in SMART
SM00670, PINc, 1 hit
SUPFAMiSSF48452, SSF48452, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH0YZZ8_TAEGU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H0YZZ8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: June 17, 2020
Last modified: October 7, 2020
This is version 54 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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