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Entry version 49 (07 Oct 2020)
Sequence version 2 (17 Jun 2020)
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Protein
Submitted name:

Uncharacterized protein

Gene

GTF2I

Organism
Taeniopygia guttata (Zebra finch) (Poephila guttata)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTranscription, Transcription regulationARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GTF2IImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiTaeniopygia guttata (Zebra finch) (Poephila guttata)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri59729 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaePasseriformesPasseroideaEstrildidaeEstrildinaeTaeniopygia
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007754 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni200 – 528DisorderedSequence analysisAdd BLAST329
Regioni558 – 759DisorderedSequence analysisAdd BLAST202
Regioni1078 – 1124DisorderedSequence analysisAdd BLAST47
Regioni1226 – 1254DisorderedSequence analysisAdd BLAST29

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili761 – 781Sequence analysisAdd BLAST21
Coiled coili1133 – 1153Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi249 – 263PolarSequence analysisAdd BLAST15
Compositional biasi287 – 306AcidicSequence analysisAdd BLAST20
Compositional biasi309 – 333PolarSequence analysisAdd BLAST25
Compositional biasi334 – 351PolyampholyteSequence analysisAdd BLAST18
Compositional biasi375 – 389PolarSequence analysisAdd BLAST15
Compositional biasi390 – 404PolyampholyteSequence analysisAdd BLAST15
Compositional biasi405 – 419AcidicSequence analysisAdd BLAST15
Compositional biasi436 – 466PolyampholyteSequence analysisAdd BLAST31
Compositional biasi499 – 522PolyampholyteSequence analysisAdd BLAST24
Compositional biasi581 – 661PolyampholyteSequence analysisAdd BLAST81
Compositional biasi685 – 717PolyampholyteSequence analysisAdd BLAST33
Compositional biasi728 – 743PolyampholyteSequence analysisAdd BLAST16
Compositional biasi744 – 759PolarSequence analysisAdd BLAST16
Compositional biasi1085 – 1102PolarSequence analysisAdd BLAST18
Compositional biasi1227 – 1254PolarSequence analysisAdd BLAST28

Keywords - Domaini

Coiled coilSequence analysis, RepeatARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160349

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_011773_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
H0YZX0

Identification of Orthologs from Complete Genome Data

More...
OMAi
VEVTIEX

TreeFam database of animal gene trees

More...
TreeFami
TF352524

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.90.1460.10, 6 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004212, GTF2I
IPR036647, GTF2I-like_rpt_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02946, GTF2I, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF117773, SSF117773, 6 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51139, GTF2I, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

H0YZX0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQLLAPATS IHDEESLEGR MVVTFLMSGL ESLCKELSKS KAEIACIGVY
60 70 80 90 100
ARNVFVIGTE RGRAFVNSRE DFKTDFIEYC VSEEDRPPKL QKKKTTPPVN
110 120 130 140 150
RQTVDAEELE ALRKSVEEFF CSLYGKALGK SAAVSVTFEE IQRNQSVVIV
160 170 180 190 200
QGLPEGVTFK HPSNYDVSTL KWILENKSGI TFSINRPFLE LRKHVEADMT
210 220 230 240 250
DPSHSVTPPC ESCPPVTVKT EPSKDSETNK DHGISSKMSE VTMKQERDDP
260 270 280 290 300
NYYQFNTPVP SETSGIDEKI APGKSYTEST QPNSSETSED SEDDVDDGDD
310 320 330 340 350
YNDGDEYQPP EGSQRSPSLT AEAGNTRGRN AQEFNFESSH HDMSETSEKP
360 370 380 390 400
EVEVTLEEDD DDYVPPDKRL KSSKSATEAA NTGRRNAEEF NSDSSQHDSS
410 420 430 440 450
EASDDSEAEI TSQDDDDDDE YLPSSKRKRR RTKNTRSTKE IANNRRRNAK
460 470 480 490 500
YLKSDSSRHD MSEIIENPEV EVTVEADEDD YMPSDKRQRT TDSANDNASA
510 520 530 540 550
ERRNAEEFNC ETSRHDMTET SENPEAEVTV EVSKFKAVPV LHASSMDKKT
560 570 580 590 600
GGFLLFLKDD DDNYLPPDKQ LKSNSLANES ADIESKKEME FSSETSWHDM
610 620 630 640 650
SETSENPEVE VTLEDTDHTY VYSNTRRRRT QSVNEEANSQ RRKADEFNSE
660 670 680 690 700
TSRHDMSETS ENPEVEVTLE DTDQPYVHRS KRRRRTQSVN EEANSQRRKA
710 720 730 740 750
EEFNSDSSQH DSSEASEVSE AELSSEDNDD DYVPRERRQR SPRSASSSGD
760 770 780 790 800
SGRSKGTQFN FDRWNSRITD LRTEVEELFE KKYAEAVKAN GPVSIPYTSF
810 820 830 840 850
LSHPEDLYVE GLPDGIPFRR PATYGIPRLE RILLAKDRIQ FVIKKPELLN
860 870 880 890 900
STEAPEANTV STVSNTVKED WHSRVTKLRM AVDQLFCRLY AKALGSNEPK
910 920 930 940 950
AVPYKKFEAH PTDLYVEGLP ENVSFKSPSW YGIPCLEQII QMGDRIKFVI
960 970 980 990 1000
KRPELLNHSS NEVTPPRSNP QAREDWNSKI TKLRKQVEDI FSKKFAKALG
1010 1020 1030 1040 1050
LSVSESVKVP YSMFESNPES LVVEGLPEGV PFRSPTWFGI PRLERIIRGS
1060 1070 1080 1090 1100
SKIKFVIKKP ELIISHLPLR LASKLKKKGI SPESPRRSRS SSENSSVPEI
1110 1120 1130 1140 1150
EVTIEDSPQK EQSHSDASDS NPNFKQQGKE FSFDLWNAKI TDLKQKVENL
1160 1170 1180 1190 1200
FNEKCGEALG RTGPVKVPYA LFDSYPEDFY VEGLPEGVPF RQPTTFGIPR
1210 1220 1230 1240 1250
LEKILRSKPK IKFIIKKPEM LEAAINESSD KSPQGKDNSP SKANAERTTK
1260 1270 1280 1290 1300
NSVKTAASVE DVSIVKVTIK DDESEPLSRA ESARQLREQV NELFSRKFGE
1310 1320 1330 1340 1350
ATGMNFPVKV PYRKITNYPG CVLVDGMPPG VAFKAPSYLE LSSMRKILES
1360 1370 1380 1390 1400
AEFIKFTVIR PFPGLVINNQ LLEEAEAKAE SPAPALAAAA TTTAALPEPA

QPV
Length:1,403
Mass (Da):157,864
Last modified:June 17, 2020 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3997135D9018104A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A674GBG8A0A674GBG8_TAEGU
Uncharacterized protein
GTF2I
1,365Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A674GL68A0A674GL68_TAEGU
Uncharacterized protein
GTF2I
1,376Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A674HIF3A0A674HIF3_TAEGU
Uncharacterized protein
GTF2I
267Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSTGUT00000003897; ENSTGUP00000003855; ENSTGUG00000003714

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENSTGUT00000003897; ENSTGUP00000003855; ENSTGUG00000003714

Phylogenomic databases

GeneTreeiENSGT00940000160349
HOGENOMiCLU_011773_0_0_1
InParanoidiH0YZX0
OMAiVEVTIEX
TreeFamiTF352524

Family and domain databases

Gene3Di3.90.1460.10, 6 hits
InterProiView protein in InterPro
IPR004212, GTF2I
IPR036647, GTF2I-like_rpt_sf
PfamiView protein in Pfam
PF02946, GTF2I, 6 hits
SUPFAMiSSF117773, SSF117773, 6 hits
PROSITEiView protein in PROSITE
PS51139, GTF2I, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH0YZX0_TAEGU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H0YZX0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: June 17, 2020
Last modified: October 7, 2020
This is version 49 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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Main funding by: National Institutes of Health

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