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Entry version 41 (08 May 2019)
Sequence version 1 (22 Feb 2012)
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Protein
Submitted name:

Chromodomain helicase DNA binding protein 6

Gene

CHD6

Organism
Taeniopygia guttata (Zebra finch) (Poephila guttata)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Chromodomain helicase DNA binding protein 6Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CHD6Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiTaeniopygia guttata (Zebra finch) (Poephila guttata)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri59729 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaePasseriformesPasseroideaEstrildidaeEstrildinaeTaeniopygia
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007754 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

NucleusSAAS annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini203 – 267ChromoInterPro annotationAdd BLAST65
Domaini287 – 330ChromoInterPro annotationAdd BLAST44
Domaini385 – 559Helicase ATP-bindingInterPro annotationAdd BLAST175
Domaini699 – 868Helicase C-terminalInterPro annotationAdd BLAST170

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0384 Eukaryota
COG0553 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158986

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
H0YYE6

Identification of Orthologs from Complete Genome Data

More...
OMAi
TIYQRCN

TreeFam database of animal gene trees

More...
TreeFami
TF313572

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00024 CHROMO, 2 hits
cd00079 HELICc, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.20.28.130, 1 hit
3.40.50.10810, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006576 BRK_domain
IPR037259 BRK_sf
IPR016197 Chromo-like_dom_sf
IPR000953 Chromo/chromo_shadow_dom
IPR023780 Chromo_domain
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR038718 SNF2-like_sf
IPR000330 SNF2_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00385 Chromo, 2 hits
PF00271 Helicase_C, 1 hit
PF00176 SNF2_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00592 BRK, 1 hit
SM00298 CHROMO, 2 hits
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF160481 SSF160481, 1 hit
SSF52540 SSF52540, 2 hits
SSF54160 SSF54160, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50013 CHROMO_2, 2 hits
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

H0YYE6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
NGMQDSGGTG VKKKRKKKDL GEQEGGDKAA VEVKPKRRRE PKEPKEPKKV
60 70 80 90 100
KESKKPKEPK QREVAKKPRK PREPKAPKES KDKKSGSEPA PRSRSKKSSK
110 120 130 140 150
DTPVEKKKKG KRKNEIPVNS LDLDQDLPSP SVQSPEESAE SADSQKRRSG
160 170 180 190 200
RQVKRRKYNE DLDFKVVDDD GETIAVLGAG RTSALSASTL AWQAEEPPED
210 220 230 240 250
DANIIEKILA SRMVQKEAHP GGLAFETEEF YVKYRNFSYL HCKWATLEEL
260 270 280 290 300
EKDPRISQKI KRFRNKQAQM KHIFTEPDED LFNPDYVEVD RILEVAHTKD
310 320 330 340 350
PDTGEEVTHY LVKWCSLPYE ESTWELEEDV DPGKIKEFEA LQIPPEIKHM
360 370 380 390 400
ERPASESWQK LEKSREYKNS NQLREYQLEG MNWLLFNWYN RKNCILADEM
410 420 430 440 450
GLGKTIQSIT FLSEIFLMGI HGPFLIIAPL STITNWEREF RTWTEMNAIV
460 470 480 490 500
YHGSQISRQM IQQYEMVYRD TQGNPLPGIF KFQVVITTFE MILADCPELK
510 520 530 540 550
KIQWRCVVID EAHRLKNRNC KLLEGLKLMA LEHKVLLTGT PLQNSVEELF
560 570 580 590 600
SLLNFLEPQQ FPSETAFLEE FGDLKTEEQV KKLQSILKPM MLRRLKDDVE
610 620 630 640 650
KNLAPKQETI IEVELTNIQK KYYRAILEKN FSFLSKGANQ HNMPNLINTM
660 670 680 690 700
MELRKCCNHP YLINGAEEKI LEDFRKTHCP EAPDFQLQAM IQAAGKLVLI
710 720 730 740 750
DKLLPKLIAG GHKVLIFSQM VRCLDILEDY LIQRRYTYER IDGRVRGNLR
760 770 780 790 800
QAAIDRFCKP DSDRFVFLLC TRAGGLGINL TAADTCIIFD SDWNPQNDLQ
810 820 830 840 850
AQARCHRIGQ SKAVKVYRLI TRNSYEREMF DKASLKLGLD KAVLQDINRK
860 870 880 890 900
GSTNGVQQLS KMEVEDLLRK GAYGALMDEE DEGSKFCEED IDQILQRRTQ
910 920 930 940 950
TITIQSEGKG STFAKASFVA SGNRTDISLD DPNFWQKWAK IAELDTDAKN
960 970 980 990 1000
EKESLVIDRP RVRKQTKHYN SFEEDELMEF SELDSDSDER PTRSRRLNEK
1010 1020 1030 1040 1050
TRRYLRAECF RVEKNLLIFG WGRWKDILTH GRFKWHLNEK DMEMICRALL
1060 1070 1080 1090 1100
VYCVKHYKGD DKIKSFIWDL ITPTKDGQNQ ALQNHSGLSA PVPRGRKGKK
1110 1120 1130 1140 1150
TKNQMLLPEI KNADWLATCN PEVVLHDDSY KKHLKQHCNK VLLRVRMLYY
1160 1170 1180 1190 1200
LKAEVLGEAA DKAFEGTPAR ELDVLLPDID YVEIPVDWWN AEADKSLLIG
1210 1220 1230 1240 1250
VFKHGYERYN AMRADPALCF LEKVGMPDEK LLSAEQGISD GAQDATERGI
1260 1270 1280 1290 1300
MEKEENSGEK LEGLDGHMAP TDDCDRSCSP WKAEAQDGSD SDRSCWPVSS
1310 1320 1330 1340 1350
ALTARLRRLV TVYQRCNRKE LPPRTEMLVP GNHGYWLQDE MFRRASEMDL
1360 1370 1380 1390 1400
MNKEMQKRWT RREQADFYRT VSSFGIIYDQ EKKIFDWAQF RAISRLEKKT
1410 1420 1430 1440 1450
DESLEKYFYS FVAMCKNVCG LPLWKEDGPP DPDIYVEPIT EERAARTLYR
1460 1470 1480 1490 1500
IELLRKVREQ VLKCPQLHER LKLCQPSLYL PVWWECGKHD RDLLIGTAKH
1510 1520 1530 1540 1550
GLNRTDYYIM NDPQLSFLDA YRNYAQHKRT GLPGPETLCC LYQSNSKLYS
1560 1570 1580 1590 1600
SPVYSQMDQS CETLENEAES HIKLEPVDST MSQAGGSPLD THCETFMSEV
1610 1620 1630 1640 1650
RDIISSNYDE SSLPDSLVCM MYDEKTCPSE QSSLTRDSPS CTDVGSSVAK
1660 1670 1680 1690 1700
LSEGKLEGDE DPSSCDADAM REVPFLEGLQ VVSDQMDNQN EEAEPSPSTP
1710 1720 1730 1740 1750
DSNPSQSAPS KLSKGLEQKG ALASPATGLP EHGTMERVLS VGLYSPSLHN
1760 1770 1780 1790 1800
YELKQRFISL LQEKGLKAKS GPSQSHSEED EEEEEDDDNS EAAADAEEGL
1810 1820 1830 1840 1850
NGSRTRADFD PEAHELGGEE QSSGLPTPED TCPEDLNGER ESLGLGEPGA
1860 1870 1880 1890 1900
EVREDCGLNE ESTQQHSPGQ AQSQPFSLPA PLPQGGPLGA EAPCAEGQTG
1910 1920 1930 1940 1950
CTETLHPEPQ GIKQEECENR DDGEKASSNQ SQDGPEKYLE EENKNSASVL
1960 1970 1980 1990 2000
PGEIDDLQDA RAPTIAQLLQ EKTLYSFSEW PKDRVIINRI DNICHAILKG
2010 2020 2030 2040 2050
KWPSSSQQFE AQSLLTAPAM ASNTGSRSSF TESEAPDPTF NNGVLMSRVQ
2060 2070 2080 2090 2100
KEGFLSPTFA KDERKHRRPY EFEMERDAKQ RSLEQLAAAH VHPPIVLNGW
2110 2120 2130 2140 2150
REAAVDLSRG SDGSPGNSSP FPLNTNVPKL GTVNALQSSL GMDLSGILQA
2160 2170 2180 2190 2200
GLIHPVTGQI VNGSLRRDDA AMRRRRGRRK NVEGMDLIFL KERPLPNRLQ
2210 2220 2230 2240 2250
DVQEDQPQPP QNSPLPDGPV AATSTPQPVP AAGSQEKAVP NKSLLDWLRQ
2260 2270 2280 2290 2300
QSDYTLDVPS FGTNFSDKPK QRRQRCKDPN KLDISSLTGE ERVPVVHKGT
2310 2320 2330 2340 2350
GRRGYLPENK FNRILSEPVL RDTGPRRRGR RPRNELLKGP GVVADSSSGM
2360 2370 2380 2390 2400
GPLFMNGLIA GMDLVGLQNM RNMQGIPLTG LVGFPAGFAA VPSGEDVKST
2410 2420 2430 2440 2450
LSMLPMMLPG MATVPQMFGV GGLLNSPMTT TCTATAPTSL TSTTKGGTAS
2460 2470 2480 2490 2500
TEKANEEKQG SQDGKREPLT EDKPGPSSFS NQTESAITTS SPVAFNPFLI
2510 2520 2530 2540 2550
PGMSPGLIYP SMFLSPGIGM ALPGIQQTRH SEAANLETQK RKRKKAKGEL
2560 2570 2580 2590
ANPEPETVSL PEKEAANSQN CAQQSLSVVA EKEQDGPAEE E
Length:2,591
Mass (Da):291,906
Last modified:February 22, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i90BF13CBEEB227A0
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
ABQF01051898 Genomic DNA No translation available.
ABQF01051899 Genomic DNA No translation available.
ABQF01051900 Genomic DNA No translation available.
ABQF01051901 Genomic DNA No translation available.
ABQF01051902 Genomic DNA No translation available.
ABQF01051903 Genomic DNA No translation available.
ABQF01051904 Genomic DNA No translation available.
ABQF01051905 Genomic DNA No translation available.
ABQF01051906 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSTGUT00000003357; ENSTGUP00000003324; ENSTGUG00000003179

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ABQF01051898 Genomic DNA No translation available.
ABQF01051899 Genomic DNA No translation available.
ABQF01051900 Genomic DNA No translation available.
ABQF01051901 Genomic DNA No translation available.
ABQF01051902 Genomic DNA No translation available.
ABQF01051903 Genomic DNA No translation available.
ABQF01051904 Genomic DNA No translation available.
ABQF01051905 Genomic DNA No translation available.
ABQF01051906 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSTGUT00000003357; ENSTGUP00000003324; ENSTGUG00000003179

Phylogenomic databases

eggNOGiKOG0384 Eukaryota
COG0553 LUCA
GeneTreeiENSGT00940000158986
InParanoidiH0YYE6
OMAiTIYQRCN
TreeFamiTF313572

Family and domain databases

CDDicd00024 CHROMO, 2 hits
cd00079 HELICc, 1 hit
Gene3Di2.20.28.130, 1 hit
3.40.50.10810, 1 hit
InterProiView protein in InterPro
IPR006576 BRK_domain
IPR037259 BRK_sf
IPR016197 Chromo-like_dom_sf
IPR000953 Chromo/chromo_shadow_dom
IPR023780 Chromo_domain
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR038718 SNF2-like_sf
IPR000330 SNF2_N
PfamiView protein in Pfam
PF00385 Chromo, 2 hits
PF00271 Helicase_C, 1 hit
PF00176 SNF2_N, 1 hit
SMARTiView protein in SMART
SM00592 BRK, 1 hit
SM00298 CHROMO, 2 hits
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF160481 SSF160481, 1 hit
SSF52540 SSF52540, 2 hits
SSF54160 SSF54160, 2 hits
PROSITEiView protein in PROSITE
PS50013 CHROMO_2, 2 hits
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH0YYE6_TAEGU
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H0YYE6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: May 8, 2019
This is version 41 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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