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Protein
Submitted name:

Ubiquitin carboxyl-terminal hydrolase 8

Gene

USP8

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
Ubiquitin carboxyl-terminal hydrolase 8Imported
Gene namesi
Name:USP8Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000138592.13
HGNCiHGNC:12631 USP8

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000138592

PTM / Processingi

Proteomic databases

MaxQBiH0YNL5
PeptideAtlasiH0YNL5
PRIDEiH0YNL5

Expressioni

Gene expression databases

BgeeiENSG00000138592 Expressed in 220 organ(s), highest expression level in corpus callosum
ExpressionAtlasiH0YNL5 baseline and differential

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 115USP8_dimerInterPro annotationAdd BLAST108

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili99 – 133Sequence analysisAdd BLAST35

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG1868 Eukaryota
ENOG410XP8T LUCA
GeneTreeiENSGT00860000133682

Family and domain databases

InterProiView protein in InterPro
IPR015063 USP8_dimer
PfamiView protein in Pfam
PF08969 USP8_dimer, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

H0YNL5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPAVASVPKE LYLSSSLKDL NKKTEVKPEK ISTKSYVHSA LKIFKTAEEC
60 70 80 90 100
RLDRDEERAY VLYMKYVTVY NLIKKRPDFK QQQDYFHSIL GPGNIKKAVE
110 120 130
EAERLSESLK LRYEEAEVRK KLEEKDRQEE AQRLQ
Length:135
Mass (Da):15,928
Last modified:February 22, 2012 - v1
Checksum:i3D576F07665D631E
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P40818UBP8_HUMAN
Ubiquitin carboxyl-terminal hydrola...
USP8 KIAA0055, UBPY
1,118Annotation score:
A0A075B720A0A075B720_HUMAN
Ubiquitin carboxyl-terminal hydrola...
USP8
480Annotation score:
H0YM47H0YM47_HUMAN
Ubiquitin carboxyl-terminal hydrola...
USP8
125Annotation score:
H0YKV1H0YKV1_HUMAN
Ubiquitin carboxyl-terminal hydrola...
USP8
136Annotation score:
H0YM17H0YM17_HUMAN
Ubiquitin carboxyl-terminal hydrola...
USP8
73Annotation score:
H0YLH2H0YLH2_HUMAN
Ubiquitin carboxyl-terminal hydrola...
USP8
96Annotation score:
H0YLS3H0YLS3_HUMAN
Ubiquitin carboxyl-terminal hydrola...
USP8
62Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei135Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC012170 Genomic DNA No translation available.
KF459553 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000558091; ENSP00000454059; ENSG00000138592
UCSCiuc059jdp.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC012170 Genomic DNA No translation available.
KF459553 Genomic DNA No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiH0YNL5
PeptideAtlasiH0YNL5
PRIDEiH0YNL5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000558091; ENSP00000454059; ENSG00000138592
UCSCiuc059jdp.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000138592.13
HGNCiHGNC:12631 USP8
OpenTargetsiENSG00000138592
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1868 Eukaryota
ENOG410XP8T LUCA
GeneTreeiENSGT00860000133682

Miscellaneous databases

ChiTaRSiUSP8 human

Gene expression databases

BgeeiENSG00000138592 Expressed in 220 organ(s), highest expression level in corpus callosum
ExpressionAtlasiH0YNL5 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR015063 USP8_dimer
PfamiView protein in Pfam
PF08969 USP8_dimer, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiH0YNL5_HUMAN
AccessioniPrimary (citable) accession number: H0YNL5
Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: September 12, 2018
This is version 42 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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