UniProtKB - H0YNL5 (H0YNL5_HUMAN)

BLAST

>tr|H0YNL5|H0YNL5_HUMAN Ubiquitin carboxyl-terminal hydrolase 8 (Fragment) OS=Homo sapiens OX=9606 GN=USP8 PE=1 SV=1
MPAVASVPKELYLSSSLKDLNKKTEVKPEKISTKSYVHSALKIFKTAEECRLDRDEERAY
VLYMKYVTVYNLIKKRPDFKQQQDYFHSILGPGNIKKAVEEAERLSESLKLRYEEAEVRK
KLEEKDRQEEAQRLQ

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History
Entry version 42 (12 Sep 2018)
Sequence version 1 (22 Feb 2012)
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Protein

Submitted name:

Ubiquitin carboxyl-terminal hydrolase 8

Gene

USP8

Organism

Homo sapiens (Human)

Status

Unreviewed-Annotation score: -Experimental evidence at protein levelⁱ

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Ubiquitin carboxyl-terminal hydrolase 8Imported
Gene namesⁱ	Name:USP8Imported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 15

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000138592.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:12631 USP8

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000138592

OpenTargetsⁱ

ENSG00000138592

PTM / Processingⁱ

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	H0YNL5
PeptideAtlas More...PeptideAtlasⁱ	H0YNL5
PRIDEⁱ	H0YNL5

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000138592 Expressed in 220 organ(s), highest expression level in corpus callosum
ExpressionAtlasⁱ	H0YNL5 baseline and differential

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	8 – 115	USP8_dimerInterPro annotationAdd BLAST		108

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	99 – 133	Sequence analysisAdd BLAST		35

Keywords - Domainⁱ

Coiled coilSequence analysis

Phylogenomic databases

eggNOGⁱ	KOG1868 Eukaryota ENOG410XP8T LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00860000133682

Family and domain databases

InterProⁱ	View protein in InterPro IPR015063 USP8_dimer
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08969 USP8_dimer, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Fragment.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show all Align All

H0YNL5-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MPAVASVPKE LYLSSSLKDL NKKTEVKPEK ISTKSYVHSA LKIFKTAEEC 
        60         70         80         90        100
RLDRDEERAY VLYMKYVTVY NLIKKRPDFK QQQDYFHSIL GPGNIKKAVE 
       110        120        130 
EAERLSESLK LRYEEAEVRK KLEEKDRQEE AQRLQ

Length:135

Mass (Da):15,928

Last modified:February 22, 2012 - v1

Checksum:ⁱ3D576F07665D631E

Computationally mapped potential isoform sequencesⁱ

There are 7 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

P40818	UBP8_HUMAN	Ubiquitin carboxyl-terminal hydrola... Ubiquitin carboxyl-terminal hydrolase 8, EC 3.4.19.12 (Deubiquitinating enzyme 8) (Ubiquitin isopeptidase Y, hUBPy) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8)	USP8 KIAA0055, UBPY	1,118	Annotation score:
A0A075B720	A0A075B720_HUMAN	Ubiquitin carboxyl-terminal hydrola... Ubiquitin carboxyl-terminal hydrolase 8	USP8	480	Annotation score:
H0YM47	H0YM47_HUMAN	Ubiquitin carboxyl-terminal hydrola... Ubiquitin carboxyl-terminal hydrolase 8	USP8	125	Annotation score:
H0YKV1	H0YKV1_HUMAN	Ubiquitin carboxyl-terminal hydrola... Ubiquitin carboxyl-terminal hydrolase 8	USP8	136	Annotation score:
H0YM17	H0YM17_HUMAN	Ubiquitin carboxyl-terminal hydrola... Ubiquitin carboxyl-terminal hydrolase 8	USP8	73	Annotation score:
H0YLH2	H0YLH2_HUMAN	Ubiquitin carboxyl-terminal hydrola... Ubiquitin carboxyl-terminal hydrolase 8	USP8	96	Annotation score:
H0YLS3	H0YLS3_HUMAN	Ubiquitin carboxyl-terminal hydrola... Ubiquitin carboxyl-terminal hydrolase 8	USP8	62	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Non-terminal residueⁱ	135	Imported		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC012170 Genomic DNA No translation available. KF459553 Genomic DNA No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AC012170 Genomic DNA No translation available.
KF459553 Genomic DNA No translation available.

Genome annotation databases

Ensemblⁱ	ENST00000558091; ENSP00000454059; ENSG00000138592
UCSC genome browser More...UCSCⁱ	uc059jdp.1 human

Protein	Similar proteins		Species	Score	Length	Source
H0YNL5	Ubiquitin carboxyl-terminal hydrolase 8	)	HUMAN		1118	UniRef100_P40818
Uncharacterized protein		PANPA		331
USP8 isoform 1 (Fragment)		PONAB		229
USP8 isoform 13 (Fragment)		PANTR		229
Ubiquitin specific peptidase 8, isoform CRA_a		HUMAN		1118
+6

Protein	Similar proteins		Species	Score	Length	Source
H0YNL5	Ubiquitin carboxyl-terminal hydrolase 8	)	HUMAN		1118	UniRef90_P40818
Uncharacterized protein		PANPA		331
USP8 isoform 1 (Fragment)		PONAB		229
USP8 isoform 13 (Fragment)		PANTR		229
Ubiquitin specific peptidase 8		AILME		1119
+90

Protein	Similar proteins		Species	Score	Length	Source
H0YNL5	Ubiquitin carboxyl-terminal hydrolase 8	)	HUMAN		1118	UniRef50_P40818
Ubiquitin carboxyl-terminal hydrolase 8	)	MOUSE		1080
Uncharacterized protein		PANPA		331
USP8 isoform 1 (Fragment)		PONAB		229
USP8 isoform 13 (Fragment)		PANTR		229
+501

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC012170 Genomic DNA No translation available. KF459553 Genomic DNA No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AC012170 Genomic DNA No translation available.
KF459553 Genomic DNA No translation available.

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

MaxQBⁱ	H0YNL5
PeptideAtlasⁱ	H0YNL5
PRIDEⁱ	H0YNL5

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000558091; ENSP00000454059; ENSG00000138592
UCSCⁱ	uc059jdp.1 human

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000138592.13
HGNCⁱ	HGNC:12631 USP8
OpenTargetsⁱ	ENSG00000138592
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1868 Eukaryota ENOG410XP8T LUCA
GeneTreeⁱ	ENSGT00860000133682

Miscellaneous databases

ChiTaRSⁱ	USP8 human

ChiTaRSⁱ

USP8 human

Gene expression databases

Bgeeⁱ	ENSG00000138592 Expressed in 220 organ(s), highest expression level in corpus callosum
ExpressionAtlasⁱ	H0YNL5 baseline and differential

Family and domain databases

InterProⁱ	View protein in InterPro IPR015063 USP8_dimer
Pfamⁱ	View protein in Pfam PF08969 USP8_dimer, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	H0YNL5_HUMAN
Accessionⁱ	H0YNL5Primary (citable) accession number: H0YNL5
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	February 22, 2012
	Last sequence update:	February 22, 2012
	Last modified:	September 12, 2018
	This is version 42 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

UniProtKB - H0YNL5 (H0YNL5_HUMAN)

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Ubiquitin carboxyl-terminal hydrolase 8

USP8

Select a section on the left to see content.

Names & Taxonomyⁱ

Organism-specific databases

Pathology & Biotechⁱ

Organism-specific databases

PTM / Processingⁱ

Proteomic databases

Expressionⁱ

Gene expression databases

Family & Domainsⁱ

Domains and Repeats

Coiled coil

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

Sequence (1+)ⁱ

Computationally mapped potential isoform sequencesⁱ

Experimental Info

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ

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UniRef

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Supporting data

UniProtKB - H0YNL5 (H0YNL5_HUMAN)

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Ubiquitin carboxyl-terminal hydrolase 8

USP8

Select a section on the left to see content.

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Names & Taxonomyⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ