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Protein
Submitted name:

RAS guanyl-releasing protein 1

Gene

RASGRP1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi160 – 171PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGuanine-nucleotide releasing factorPROSITE-ProRule annotationSAAS annotation
LigandCalciumPROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
RAS guanyl-releasing protein 1Imported
Gene namesi
Name:RASGRP1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000172575.11
HGNCiHGNC:9878 RASGRP1

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000172575

PTM / Processingi

Proteomic databases

MaxQBiH0YNK9
PeptideAtlasiH0YNK9
PRIDEiH0YNK9

Expressioni

Gene expression databases

BgeeiENSG00000172575 Expressed in 198 organ(s), highest expression level in cerebellum
ExpressionAtlasiH0YNK9 baseline and differential

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliH0YNK9
SMRiH0YNK9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 148Ras-GEFInterPro annotationAdd BLAST148
Domaini147 – 182EF-handInterPro annotationAdd BLAST36

Phylogenomic databases

GeneTreeiENSGT00880000137870

Family and domain databases

Gene3Di1.10.840.10, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR008937 Ras-like_GEF
IPR023578 Ras_GEF_dom_sf
IPR001895 RASGEF_cat_dom
IPR036964 RASGEF_cat_dom_sf
PANTHERiPTHR23113 PTHR23113, 1 hit
PfamiView protein in Pfam
PF13405 EF-hand_6, 1 hit
PF00617 RasGEF, 1 hit
SMARTiView protein in SMART
SM00147 RasGEF, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
SSF48366 SSF48366, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 1 hit
PS50009 RASGEF_CAT, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

H0YNK9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
QNFNTLMAVI GGLCHSSISR LKETSSHVPH EINKVLGEMT ELLSSSRNYD
60 70 80 90 100
NYRRAYGECT DFKIPILGVH LKDLISLYEA MPDYLEDGKV NVHKLLALYN
110 120 130 140 150
HISELVQLQE VAPPLEANKD LVHLLTLSLD LYYTEDEIYE LSYAREPRNH
160 170 180 190 200
RAPSVFKNYD HDQDGYISQE EFEKIAASFP FSFCVMDKDR AHGSNHEVAH
210
TILPLRIKRK GRPHQQG
Length:217
Mass (Da):24,924
Last modified:February 22, 2012 - v1
Checksum:iDF3237C74E7EC387
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
O95267GRP1_HUMAN
RAS guanyl-releasing protein 1
RASGRP1 RASGRP
797Annotation score:
H0YKM0H0YKM0_HUMAN
RAS guanyl-releasing protein 1
RASGRP1
848Annotation score:
H0YMF3H0YMF3_HUMAN
RAS guanyl-releasing protein 1
RASGRP1
811Annotation score:
F5H514F5H514_HUMAN
RAS guanyl-releasing protein 1
RASGRP1
797Annotation score:
H0YN83H0YN83_HUMAN
RAS guanyl-releasing protein 1
RASGRP1
96Annotation score:
H0YNG8H0YNG8_HUMAN
RAS guanyl-releasing protein 1
RASGRP1
57Annotation score:
H0YMT0H0YMT0_HUMAN
RAS guanyl-releasing protein 1
RASGRP1
123Annotation score:
H0YKP8H0YKP8_HUMAN
RAS guanyl-releasing protein 1
RASGRP1
32Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC116158 Genomic DNA No translation available.
AC124306 Genomic DNA No translation available.
KF456047 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000560425; ENSP00000454053; ENSG00000172575
UCSCiuc059hmk.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC116158 Genomic DNA No translation available.
AC124306 Genomic DNA No translation available.
KF456047 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliH0YNK9
SMRiH0YNK9
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiH0YNK9
PeptideAtlasiH0YNK9
PRIDEiH0YNK9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000560425; ENSP00000454053; ENSG00000172575
UCSCiuc059hmk.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000172575.11
HGNCiHGNC:9878 RASGRP1
OpenTargetsiENSG00000172575
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00880000137870

Gene expression databases

BgeeiENSG00000172575 Expressed in 198 organ(s), highest expression level in cerebellum
ExpressionAtlasiH0YNK9 baseline and differential

Family and domain databases

Gene3Di1.10.840.10, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR008937 Ras-like_GEF
IPR023578 Ras_GEF_dom_sf
IPR001895 RASGEF_cat_dom
IPR036964 RASGEF_cat_dom_sf
PANTHERiPTHR23113 PTHR23113, 1 hit
PfamiView protein in Pfam
PF13405 EF-hand_6, 1 hit
PF00617 RasGEF, 1 hit
SMARTiView protein in SMART
SM00147 RasGEF, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
SSF48366 SSF48366, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 1 hit
PS50009 RASGEF_CAT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiH0YNK9_HUMAN
AccessioniPrimary (citable) accession number: H0YNK9
Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: November 7, 2018
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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