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Protein
Submitted name:

Signal peptide peptidase-like 2A

Gene

SPPL2A

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Signal peptide peptidase-like 2AImported
Gene namesi
Name:SPPL2AImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000138600.9
HGNCiHGNC:30227 SPPL2A

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei126 – 147HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000138600

PTM / Processingi

Proteomic databases

EPDiH0YNA7
PeptideAtlasiH0YNA7
PRIDEiH0YNA7

Expressioni

Gene expression databases

BgeeiENSG00000138600 Expressed in 203 organ(s), highest expression level in secondary oocyte
ExpressionAtlasiH0YNA7 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliH0YNA7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 102PAInterPro annotationAdd BLAST66

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG2442 Eukaryota
ENOG410ZP52 LUCA
GeneTreeiENSGT00530000062920

Family and domain databases

InterProiView protein in InterPro
IPR003137 PA_domain
IPR007369 Peptidase_A22B_SPP
IPR033151 SPPL2a
PANTHERiPTHR12174 PTHR12174, 1 hit
PTHR12174:SF34 PTHR12174:SF34, 1 hit
PfamiView protein in Pfam
PF02225 PA, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

H0YNA7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLYNPYWTAL PSTLENATSI SLMNLTSTPL CNLSDIPPVG IKSKAVVVPW
60 70 80 90 100
GSCHFLEKAR IAQKGGAEAM LVVNNSVLFP PSGNRSEFPD VKILIAFISY
110 120 130 140
KDFRDMNQTL GDNITVKMYS PSWPNFDYTM VVIFVIAVFT VALGGYWSG
Length:149
Mass (Da):16,432
Last modified:October 5, 2016 - v8
Checksum:iBB0937058055885A
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8TCT8SPP2A_HUMAN
Signal peptide peptidase-like 2A
SPPL2A IMP3, PSL2, PSEC0147
520Annotation score:
H0YNA2H0YNA2_HUMAN
Signal peptide peptidase-like 2A
SPPL2A
356Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei149Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC012100 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000558414; ENSP00000453932; ENSG00000138600
UCSCiuc059jes.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC012100 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliH0YNA7
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

EPDiH0YNA7
PeptideAtlasiH0YNA7
PRIDEiH0YNA7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000558414; ENSP00000453932; ENSG00000138600
UCSCiuc059jes.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000138600.9
HGNCiHGNC:30227 SPPL2A
OpenTargetsiENSG00000138600
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2442 Eukaryota
ENOG410ZP52 LUCA
GeneTreeiENSGT00530000062920

Gene expression databases

BgeeiENSG00000138600 Expressed in 203 organ(s), highest expression level in secondary oocyte
ExpressionAtlasiH0YNA7 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR003137 PA_domain
IPR007369 Peptidase_A22B_SPP
IPR033151 SPPL2a
PANTHERiPTHR12174 PTHR12174, 1 hit
PTHR12174:SF34 PTHR12174:SF34, 1 hit
PfamiView protein in Pfam
PF02225 PA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiH0YNA7_HUMAN
AccessioniPrimary (citable) accession number: H0YNA7
Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: October 5, 2016
Last modified: September 12, 2018
This is version 46 of the entry and version 8 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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