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Protein
Submitted name:

Uveal autoantigen with coiled-coil domains and ankyrin repeats

Gene

UACA

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Uveal autoantigen with coiled-coil domains and ankyrin repeatsImported
Gene namesi
Name:UACAImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000137831.14
HGNCiHGNC:15947 UACA

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000137831

PTM / Processingi

Proteomic databases

EPDiH0YN48
MaxQBiH0YN48
PeptideAtlasiH0YN48
PRIDEiH0YN48

Expressioni

Gene expression databases

BgeeiENSG00000137831 Expressed in 212 organ(s), highest expression level in visceral pleura
ExpressionAtlasiH0YN48 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliH0YN48
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 251ANK_REP_REGIONInterPro annotationAdd BLAST227
Repeati54 – 86ANKPROSITE-ProRule annotationAdd BLAST33
Repeati87 – 119ANKPROSITE-ProRule annotationAdd BLAST33
Repeati120 – 152ANKPROSITE-ProRule annotationAdd BLAST33
Repeati153 – 185ANKPROSITE-ProRule annotationAdd BLAST33
Repeati186 – 218ANKPROSITE-ProRule annotationAdd BLAST33

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili276 – 310Sequence analysisAdd BLAST35
Coiled coili314 – 348Sequence analysisAdd BLAST35
Coiled coili429 – 449Sequence analysisAdd BLAST21
Coiled coili454 – 488Sequence analysisAdd BLAST35
Coiled coili515 – 542Sequence analysisAdd BLAST28

Keywords - Domaini

ANK repeatPROSITE-ProRule annotation, Coiled coilSequence analysis

Phylogenomic databases

eggNOGiENOG410IJC6 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00530000063369

Family and domain databases

CDDicd00204 ANK, 2 hits
Gene3Di1.25.40.20, 2 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR030227 UACA
PANTHERiPTHR24173:SF23 PTHR24173:SF23, 1 hit
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 6 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 5 hits

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

H0YN48-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMNCWFSCTP KNRHAADWNK YDDRLMKAAE RGDVEKVTSI LAKKGVNPGK
60 70 80 90 100
LDVEGRSVFH VVTSKGNLEC LNAILIHGVD ITTSDTAGRN ALHLAAKYGH
110 120 130 140 150
ALCLQKLLQY NCPTEHADLQ GRTALHDAAM ADCPSSIQLL CDHGASVNAK
160 170 180 190 200
DVDGRTPLVL ATQMSRPTIC QLLIDRGADV NSRDKQNRTA LMLGCEYGCR
210 220 230 240 250
DAVEVLIKNG ADISLLDALG HDSSYYARIG DNLDILTLLK TASENTNKGR
260 270 280 290 300
ELWKKGPSLQ QRNLTHMQDE VNVKSHQREH QNIQDLEIEN EDLKERLRKI
310 320 330 340 350
QQEQRILLDK VNGLQLQLNE REKLKSLLAA KEKQHEESLR TIEALKNRFK
360 370 380 390 400
YFESDHLGSG SHFSNRKEDM LLKQGQMYMA DSQCTSPGIP AHMQSRSMLR
410 420 430 440 450
PLELSLPSQT SYSENEILKK ELEAMRTFCE SAKQDRLKLQ NELAHKVAEC
460 470 480 490 500
KALALECERV KEDSDEQIKQ LEDALKDVQK RMYESEGKVK QMQTHFLALK
510 520 530 540 550
EHLTSEAASG NHRLTEELKD QLKDLKVKYE GASAEVGKLR NQIKQNEMIV
560
EEFKRDEGKL IEEN
Length:564
Mass (Da):63,893
Last modified:February 22, 2012 - v1
Checksum:i7F0BD687CF538421
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9BZF9UACA_HUMAN
Uveal autoantigen with coiled-coil ...
UACA KIAA1561
1,416Annotation score:
H0YNH8H0YNH8_HUMAN
Uveal autoantigen with coiled-coil ...
UACA
1,401Annotation score:
F5H2B9F5H2B9_HUMAN
Uveal autoantigen with coiled-coil ...
UACA
1,307Annotation score:
H0YMI1H0YMI1_HUMAN
Uveal autoantigen with coiled-coil ...
UACA
225Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei564Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009269 Genomic DNA No translation available.
AC087699 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000558758; ENSP00000453865; ENSG00000137831
UCSCiuc059kvs.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009269 Genomic DNA No translation available.
AC087699 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliH0YN48
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

EPDiH0YN48
MaxQBiH0YN48
PeptideAtlasiH0YN48
PRIDEiH0YN48

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000558758; ENSP00000453865; ENSG00000137831
UCSCiuc059kvs.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000137831.14
HGNCiHGNC:15947 UACA
OpenTargetsiENSG00000137831
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJC6 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00530000063369

Miscellaneous databases

ChiTaRSiUACA human

Gene expression databases

BgeeiENSG00000137831 Expressed in 212 organ(s), highest expression level in visceral pleura
ExpressionAtlasiH0YN48 baseline and differential

Family and domain databases

CDDicd00204 ANK, 2 hits
Gene3Di1.25.40.20, 2 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR030227 UACA
PANTHERiPTHR24173:SF23 PTHR24173:SF23, 1 hit
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 6 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 5 hits
ProtoNetiSearch...

Entry informationi

Entry nameiH0YN48_HUMAN
AccessioniPrimary (citable) accession number: H0YN48
Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: September 12, 2018
This is version 44 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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