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Protein
Submitted name:

Zinc finger E-box-binding homeobox 1

Gene

ZEB1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Zinc finger E-box-binding homeobox 1Imported
Gene namesi
Name:ZEB1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000148516.21
HGNCiHGNC:11642 ZEB1

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000148516

PTM / Processingi

Proteomic databases

MaxQBiH0YMD3
PeptideAtlasiH0YMD3
PRIDEiH0YMD3

Expressioni

Gene expression databases

BgeeiENSG00000148516 Expressed in 238 organ(s), highest expression level in myometrium
ExpressionAtlasiH0YMD3 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliH0YMD3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 49C2H2-typeInterPro annotationAdd BLAST28

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3623 Eukaryota
ENOG410ZFMZ LUCA
GeneTreeiENSGT00630000089829

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 2 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 2 hits
SUPFAMiSSF57667 SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 1 hit
PS50157 ZINC_FINGER_C2H2_2, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

H0YMD3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTSHKSGRDQ RHVTQSGCNR KFKCTECGKA FKYKHHLKEH LRIHSGEKPY
60 70 80 90 100
ECPNCKKRFS HSGSYSSHIS SKKCISLIPV NGRPRTGLKT SQCSSPSLSA
110 120 130 140 150
SPGSPTRPQI RQKIENKPLQ EQLSVNQIKT EPVDYEFKPI VVASGINCST
160 170 180 190 200
PLQNGVFTGG GPLQATSSPQ GMVQAVVLPT VGLVSPISIN LSDIQNVLKV
210 220 230 240 250
AVDGNVIRQV LENNQANLAS KEQETINASP IQQGGHSVIS AISLPLVDQD
260 270
GTTKIIINYS LEQPSQLQVV PQNL
Length:274
Mass (Da):29,751
Last modified:October 29, 2014 - v3
Checksum:iE8205A17AF142A56
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P37275ZEB1_HUMAN
Zinc finger E-box-binding homeobox ...
ZEB1 AREB6, TCF8
1,124Annotation score:
H0YMN2H0YMN2_HUMAN
Zinc finger E-box-binding homeobox ...
ZEB1
277Annotation score:
F6TDF5F6TDF5_HUMAN
Zinc finger E-box-binding homeobox ...
ZEB1
289Annotation score:
H0YND9H0YND9_HUMAN
Zinc finger E-box-binding homeobox ...
ZEB1
288Annotation score:
F6U0D0F6U0D0_HUMAN
Zinc finger E-box-binding homeobox ...
ZEB1
53Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei274Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL117340 Genomic DNA No translation available.
AL158080 Genomic DNA No translation available.
AL161935 Genomic DNA No translation available.
AL355148 Genomic DNA No translation available.
KF455221 Genomic DNA No translation available.
KF511092 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000561212; ENSP00000453559; ENSG00000148516
UCSCiuc057soq.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL117340 Genomic DNA No translation available.
AL158080 Genomic DNA No translation available.
AL161935 Genomic DNA No translation available.
AL355148 Genomic DNA No translation available.
KF455221 Genomic DNA No translation available.
KF511092 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliH0YMD3
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiH0YMD3
PeptideAtlasiH0YMD3
PRIDEiH0YMD3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000561212; ENSP00000453559; ENSG00000148516
UCSCiuc057soq.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000148516.21
HGNCiHGNC:11642 ZEB1
OpenTargetsiENSG00000148516
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3623 Eukaryota
ENOG410ZFMZ LUCA
GeneTreeiENSGT00630000089829

Miscellaneous databases

ChiTaRSiZEB1 human

Gene expression databases

BgeeiENSG00000148516 Expressed in 238 organ(s), highest expression level in myometrium
ExpressionAtlasiH0YMD3 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 2 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 2 hits
SUPFAMiSSF57667 SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 1 hit
PS50157 ZINC_FINGER_C2H2_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiH0YMD3_HUMAN
AccessioniPrimary (citable) accession number: H0YMD3
Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: October 29, 2014
Last modified: October 10, 2018
This is version 46 of the entry and version 3 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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