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Protein
Submitted name:

DmX-like protein 2

Gene

DMXL2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

SignaLinkiH0YLM8

Names & Taxonomyi

Protein namesi
Submitted name:
DmX-like protein 2Imported
Gene namesi
Name:DMXL2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000104093.13
HGNCiHGNC:2938 DMXL2

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000104093

PTM / Processingi

Proteomic databases

EPDiH0YLM8
MaxQBiH0YLM8
PeptideAtlasiH0YLM8
PRIDEiH0YLM8

Expressioni

Gene expression databases

BgeeiENSG00000104093 Expressed in 211 organ(s), highest expression level in intestine
ExpressionAtlasiH0YLM8 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliH0YLM8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini906 – 1126WD_REPEATS_REGIONInterPro annotationAdd BLAST221
Repeati1043 – 1084WDPROSITE-ProRule annotationAdd BLAST42
Repeati1085 – 1126WDPROSITE-ProRule annotationAdd BLAST42

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili249 – 276Sequence analysisAdd BLAST28

Keywords - Domaini

Coiled coilSequence analysis, WD repeatPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1064 Eukaryota
ENOG410XPUM LUCA
GeneTreeiENSGT00390000000096

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 1 hit
SMARTiView protein in SMART
SM00320 WD40, 6 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50082 WD_REPEATS_2, 2 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

H0YLM8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
XINLIERKLF FTTANAHFKV GCPVLALEVL SKIPKVTKTS ALSAKKDQPD
60 70 80 90 100
FISHRMDDVP SHSKALSDGN GSSGIEWSNV TSSQYDWSQP IVKVDEEPLN
110 120 130 140 150
LDWGEDHDSA LDEEEDDAVG LVMKSTDARE KDKQSDQKAS DPNMLLTPQE
160 170 180 190 200
EDDPEGDTEV DVIAEQLKFR ACLKILMTEL RTLATGYEVD GGKLRFQLYN
210 220 230 240 250
WLEKEIAALH EICNHESVIK EYSSKTYSKV ESDLLDQEEM VDKPDIGSYE
260 270 280 290 300
RHQIERRRLQ AKREHAERRK SWLQKNQDLL RVFLSYCSLH GAQGGGLASV
310 320 330 340 350
RMELKFLLQE SQQETTVKQL QSPLPLPTTL PLLSASIAST KTVIANPVLY
360 370 380 390 400
LNNHIHDILY TIVQMKTPPH PSIEDVKVHT LHSLAASLSA SIYQALCDSH
410 420 430 440 450
SYSSQTEGNQ FTGMAYQGLL LSDRRRLRTE SIEEHATPNS SPAQWPGVSS
460 470 480 490 500
LINLLSSAQD EDQPKLNILL CEAVVAVYLS LLIHALATNS SSELFRLAAH
510 520 530 540 550
PLNNRMWAAV FGGGVKLVVK PRRQSENISA PPVLSEDIDK HRRRFNMRML
560 570 580 590 600
VPGRPVKDAT PPPVPAERPS YKEKFIPPEL SMWDYFVAKP FLPLSDSGVI
610 620 630 640 650
YDSDESIHSD EEDDAFFSDT QIQEHQDPNS YSWALLHLTM VKLALHNVKN
660 670 680 690 700
FFPIAGLEFS ELPVTSPLGI AVIKNLENWE QILQEKMDQF EGPPPNYINT
710 720 730 740 750
YPTDLSVGAG PAILRNKAML EPENTPFKSR DSSAFPVKRL WHFLVKQEVL
760 770 780 790 800
QETFIRYIFT KKRKQSESIE EHVEQVNQNC IAEDCHIKVE ADLGYPGGKA
810 820 830 840 850
KVIHKESDMI MAFSVNKANC NEIVLASTHD VQELDVTSLL ACQSYIWIGE
860 870 880 890 900
EYDRESKSSD DVDYRGSTTT LYQPSATSYS ASQVHPPSSL PWLGTGQTST
910 920 930 940 950
GASVLMKRNL HNVKRMTSHP VHQYYLTGAQ DGSVRMFEWT RPQQLVCFRQ
960 970 980 990 1000
AGNARVTRLY FNSQGNKCGV ADGEGFLSIW QVNQTASNPK PYMSWQCHSK
1010 1020 1030 1040 1050
ATSDFAFITS SSLVATSGHS NDNRNVCLWD TLISPGNSLI HGFTCHDHGA
1060 1070 1080 1090 1100
TVLQYAPKQQ LLISGGRKGH VCIFDIRQRQ LIHTFQAHDS AIKALALDPY
1110 1120 1130 1140 1150
EEYFTTGSAE GNIKVWRLTG HGLIHSFKSE HAKQSIFRNI GAGVMQIDII
1160 1170 1180
QGNRLFSCGA DGTLKTRVLP NAFNIPNRIL DIL
Length:1,183
Mass (Da):132,647
Last modified:February 22, 2012 - v1
Checksum:i84E4DABA588CA9A1
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8TDJ6DMXL2_HUMAN
DmX-like protein 2
DMXL2 KIAA0856
3,036Annotation score:
H0YM41H0YM41_HUMAN
DmX-like protein 2
DMXL2
115Annotation score:
H0YME1H0YME1_HUMAN
DmX-like protein 2
DMXL2
76Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC020892 Genomic DNA No translation available.
AC066613 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000560891; ENSP00000453267; ENSG00000104093
UCSCiuc059jgc.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC020892 Genomic DNA No translation available.
AC066613 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliH0YLM8
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

EPDiH0YLM8
MaxQBiH0YLM8
PeptideAtlasiH0YLM8
PRIDEiH0YLM8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000560891; ENSP00000453267; ENSG00000104093
UCSCiuc059jgc.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000104093.13
HGNCiHGNC:2938 DMXL2
OpenTargetsiENSG00000104093
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1064 Eukaryota
ENOG410XPUM LUCA
GeneTreeiENSGT00390000000096

Enzyme and pathway databases

SignaLinkiH0YLM8

Miscellaneous databases

ChiTaRSiDMXL2 human

Gene expression databases

BgeeiENSG00000104093 Expressed in 211 organ(s), highest expression level in intestine
ExpressionAtlasiH0YLM8 baseline and differential

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 1 hit
SMARTiView protein in SMART
SM00320 WD40, 6 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50082 WD_REPEATS_2, 2 hits
PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiH0YLM8_HUMAN
AccessioniPrimary (citable) accession number: H0YLM8
Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: September 12, 2018
This is version 50 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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