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Protein
Submitted name:

Unconventional myosin-Ie

Gene

MYO1E

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionActin-bindingPROSITE-ProRule annotation, Motor protein, MyosinPROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Unconventional myosin-IeImported
Gene namesi
Name:MYO1EImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000157483.8
HGNCiHGNC:7599 MYO1E

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000157483

PTM / Processingi

Proteomic databases

MaxQBiH0YLJ4
PeptideAtlasiH0YLJ4
PRIDEiH0YLJ4

Expressioni

Gene expression databases

BgeeiENSG00000157483 Expressed in 181 organ(s), highest expression level in corpus callosum
ExpressionAtlasiH0YLJ4 baseline and differential

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliH0YLJ4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 276Myosin motorInterPro annotationAdd BLAST276
Domaini146 – 276TH1InterPro annotationAdd BLAST131

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0164 Eukaryota
COG5022 LUCA
GeneTreeiENSGT00930000150810

Family and domain databases

InterProiView protein in InterPro
IPR001609 Myosin_head_motor_dom
IPR010926 Myosin_TH1
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00063 Myosin_head, 1 hit
PF06017 Myosin_TH1, 1 hit
SMARTiView protein in SMART
SM00242 MYSc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51456 MYOSIN_MOTOR, 1 hit
PS51757 TH1, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

H0YLJ4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
GKYFEIQFSP GGEPDGGKIS NFLLEKSRVV MRNPGERSFH IFYQLIEGAS
60 70 80 90 100
AEQKHSLGIT SMDYYYYLSL SGSYKVDDID DRREFQETLH AMNVIGIFAE
110 120 130 140 150
EQTLVLQIVA GILHLGNISF KEVGNYAAVE SEEFLAFPAY LLGINQDRLK
160 170 180 190 200
EKLTSRQMDS KWGGKSESIH VTLNVEQACY TRDALAKALH ARVFDFLVDG
210 220 230 240 250
VKRDLLLTPK CLYLIGREKV KQGPDKGLVK EVLKRKIEIE RILSVSLSTM
260 270
QDDIFILHEQ EYDSLLESVF KTEFLS
Length:276
Mass (Da):31,405
Last modified:February 22, 2012 - v1
Checksum:iB4CC0970E2E55A13
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q12965MYO1E_HUMAN
Unconventional myosin-Ie
MYO1E MYO1C
1,108Annotation score:
H0YNQ8H0YNQ8_HUMAN
Unconventional myosin-Ie
MYO1E
317Annotation score:
H0YLE5H0YLE5_HUMAN
Unconventional myosin-Ie
MYO1E
187Annotation score:
H0YN00H0YN00_HUMAN
Unconventional myosin-Ie
MYO1E
112Annotation score:
H0YNB0H0YNB0_HUMAN
Unconventional myosin-Ie
MYO1E
73Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1
Non-terminal residuei276Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC092756 Genomic DNA No translation available.
AC092757 Genomic DNA No translation available.
AC092868 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000559269; ENSP00000453232; ENSG00000157483
UCSCiuc059jtz.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC092756 Genomic DNA No translation available.
AC092757 Genomic DNA No translation available.
AC092868 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliH0YLJ4
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiH0YLJ4
PeptideAtlasiH0YLJ4
PRIDEiH0YLJ4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000559269; ENSP00000453232; ENSG00000157483
UCSCiuc059jtz.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000157483.8
HGNCiHGNC:7599 MYO1E
OpenTargetsiENSG00000157483
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0164 Eukaryota
COG5022 LUCA
GeneTreeiENSGT00930000150810

Miscellaneous databases

ChiTaRSiMYO1E human

Gene expression databases

BgeeiENSG00000157483 Expressed in 181 organ(s), highest expression level in corpus callosum
ExpressionAtlasiH0YLJ4 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR001609 Myosin_head_motor_dom
IPR010926 Myosin_TH1
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00063 Myosin_head, 1 hit
PF06017 Myosin_TH1, 1 hit
SMARTiView protein in SMART
SM00242 MYSc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51456 MYOSIN_MOTOR, 1 hit
PS51757 TH1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiH0YLJ4_HUMAN
AccessioniPrimary (citable) accession number: H0YLJ4
Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: November 7, 2018
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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