Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transmembrane protein 250

Gene

TMEM250

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in cell proliferation by promoting progression into S phase.1 Publication
(Microbial infection) Promotes human herpes simplex virus 1/HHV-1 proliferation.1 Publication

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • positive regulation of cell proliferation Source: UniProtKB
  • positive regulation of viral process Source: UniProtKB
  • viral process Source: UniProtKB-KW

Keywordsi

Biological processCell cycle, Host-virus interaction

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 250Imported
Alternative name(s):
Herpes virus UL25-binding protein1 Publication
Gene namesi
Name:TMEM250Imported
Synonyms:C9orf69
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000238227.7
HGNCiHGNC:31009 TMEM250
neXtProtiNX_H0YL14

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei56 – 76HelicalSequence analysisAdd BLAST21
Transmembranei116 – 136HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000238227

Polymorphism and mutation databases

BioMutaiC9orf69

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004209061 – 139Transmembrane protein 250Add BLAST139

Proteomic databases

MaxQBiH0YL14
PaxDbiH0YL14
PRIDEiH0YL14
ProteomicsDBi39818

Expressioni

Inductioni

Up-regulated upon HHV-1 infection.1 Publication

Gene expression databases

BgeeiENSG00000238227
ExpressionAtlasiH0YL14 baseline and differential
GenevisibleiH0YL14 HS

Organism-specific databases

HPAiHPA066070

Interactioni

Subunit structurei

(Microbial infection) Interacts with herpes simplex virus 1/HHV-1 protein CVC2/UL25.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
UL25D3YP883EBI-6399705,EBI-6449813From Human herpesvirus 1.

Protein-protein interaction databases

IntActiH0YL14, 2 interactors
STRINGi9606.ENSP00000453019

Structurei

3D structure databases

ProteinModelPortaliH0YL14
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2655 Eukaryota
COG5019 LUCA
GeneTreeiENSGT00560000078707
InParanoidiH0YL14
OMAiGHRRLDF
OrthoDBiEOG091G0VDQ

Sequencei

Sequence statusi: Complete.

H0YL14-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVMPIPRRV RSFHGPHTTC LHAACGPVRA SHLARTKYNN FDVYIKTRWL
60 70 80 90 100
YGFIRFLLYF SCSLFTAALW GALAALFCLQ YLGVRVLLRF QRKLSVLLLL
110 120 130
LGRRRVDFRL VNELLVYGIH VTMLLVGGLG WCFMVFVDM
Length:139
Mass (Da):16,083
Last modified:April 18, 2012 - v2
Checksum:i482DDEB661FD9A72
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL138781 Genomic DNA No translation available.
BC014304 mRNA No translation available.
CCDSiCCDS59155.1
RefSeqiNP_001243455.1, NM_001256526.1
NP_690046.3, NM_152833.2
UniGeneiHs.287411

Genome annotation databases

EnsembliENST00000418388; ENSP00000453019; ENSG00000238227
ENST00000557985; ENSP00000457272; ENSG00000238227
ENST00000561457; ENSP00000452750; ENSG00000238227
GeneIDi90120
KEGGihsa:90120
UCSCiuc004cgx.6 human

Similar proteinsi

Entry informationi

Entry nameiTM250_HUMAN
AccessioniPrimary (citable) accession number: H0YL14
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2013
Last sequence update: April 18, 2012
Last modified: July 18, 2018
This is version 46 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health