UniProtKB - H0YKU7 (H0YKU7_HUMAN)
Protein
Submitted name:
Transient receptor potential cation channel subfamily M member 1
Gene
TRPM1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- cation channel activity Source: InterPro
GO - Biological processi
- cellular response to light stimulus Source: InterPro
- G protein-coupled glutamate receptor signaling pathway Source: InterPro
- protein tetramerization Source: InterPro
Keywordsi
Biological process | Ion transportARBA annotation, Transport |
Names & Taxonomyi
Protein namesi | Submitted name: Transient receptor potential cation channel subfamily M member 1Imported |
Gene namesi | Name:TRPM1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:7146, TRPM1 |
VEuPathDBi | HostDB:ENSG00000134160.13 |
Subcellular locationi
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 831 – 850 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 898 – 916 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 928 – 946 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 966 – 987 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 1050 – 1075 | HelicalSequence analysisAdd BLAST | 26 | |
Transmembranei | 1106 – 1124 | HelicalSequence analysisAdd BLAST | 19 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | ENSG00000134160, Expressed in pigmented layer of retina and 87 other tissues |
ExpressionAtlasi | H0YKU7, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 70 – 335 | LSDAT_eukInterPro annotationAdd BLAST | 266 | |
Domaini | 836 – 1084 | Ion_transInterPro annotationAdd BLAST | 249 | |
Domaini | 1179 – 1234 | TRPM_tetraInterPro annotationAdd BLAST | 56 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 16 – 47 | DisorderedSequence analysisAdd BLAST | 32 | |
Regioni | 403 – 445 | DisorderedSequence analysisAdd BLAST | 43 | |
Regioni | 573 – 596 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 777 – 810 | DisorderedSequence analysisAdd BLAST | 34 | |
Regioni | 1331 – 1390 | DisorderedSequence analysisAdd BLAST | 60 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 1182 – 1202 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 1220 – 1240 | Sequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1343 – 1379 | PolyampholyteSequence analysisAdd BLAST | 37 |
Keywords - Domaini
Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000155024 |
HOGENOMi | CLU_001390_4_1_1 |
Family and domain databases
Gene3Di | 1.20.5.1010, 1 hit |
InterProi | View protein in InterPro IPR005821, Ion_trans_dom IPR029588, TRPM1 IPR041491, TRPM_SLOG IPR032415, TRPM_tetra IPR037162, TRPM_tetra_sf |
PANTHERi | PTHR13800:SF13, PTHR13800:SF13, 1 hit |
Pfami | View protein in Pfam PF00520, Ion_trans, 1 hit PF18139, LSDAT_euk, 1 hit PF16519, TRPM_tetra, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All
H0YKU7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKDSNRCCCG QFTNQHIPPL PSATPSKNEE ESKQVETQPE KWSVAKHTQS
60 70 80 90 100
YPTDSYGVLE FQGGGYSNKA MYIRVSYDTK PDSLLHLMVK DWQLELPKLL
110 120 130 140 150
ISVHGGLQNF EMQPKLKQVF GKGLIKAAMT TGAWIFTGGV STGVISHVGD
160 170 180 190 200
ALKDHSSKSR GRVCAIGIAP WGIVENKEDL VGKDVTRVYQ TMSNPLSKLS
210 220 230 240 250
VLNNSHTHFI LADNGTLGKY GAEVKLRRLL EKHISLQKIN TRLGQGVPLV
260 270 280 290 300
GLVVEGGPNV VSIVLEYLQE EPPIPVVICD GSGRASDILS FAHKYCEEGG
310 320 330 340 350
IINESLREQL LVTIQKTFNY NKAQSHQLFA IIMECMKKKE LVTVFRMGSE
360 370 380 390 400
GQQDIEMAIL TALLKGTNVS APDQLSLALA WNRVDIARSQ IFVFGPHWPP
410 420 430 440 450
LGSLAPPTDS KATEKEKKPP MATTKGGRGK GKGKKKGKVK EEVEEETDPR
460 470 480 490 500
KIELLNWVNA LEQAMLDALV LDRVDFVKLL IENGVNMQHF LTIPRLEELY
510 520 530 540 550
NTRLGPPNTL HLLVRDVKKS NLPPDYHISL IDIGLVLEYL MGGAYRCNYT
560 570 580 590 600
RKNFRTLYNN LFGPKRPKAL KLLGMEDDEP PAKGKKKKKK KKEEEIDIDV
610 620 630 640 650
DDPAVSRFQY PFHELMVWAV LMKRQKMAVF LWQRGEESMA KALVACKLYK
660 670 680 690 700
AMAHESSESD LVDDISQDLD NNSKDFGQLA LELLDQSYKH DEQIAMKLLT
710 720 730 740 750
YELKNWSNST CLKLAVAAKH RDFIAHTCSQ MLLTDMWMGR LRMRKNPGLK
760 770 780 790 800
VIMGILLPPT ILFLEFRTYD DFSYQTSKEN EDGKEKEEEN TDANADAGSR
810 820 830 840 850
KGDEENEHKK QRSIPIGTKI CEFYNAPIVK FWFYTISYLG YLLLFNYVIL
860 870 880 890 900
VRMDGWPSLQ EWIVISYIVS LALEKIREIL MSEPGKLSQK IKVWLQEYWN
910 920 930 940 950
ITDLVAISTF MIGAILRLQN QPYMGYGRVI YCVDIIFWYI RVLDIFGVNK
960 970 980 990 1000
YLGPYVMMIG KMMIDMLYFV VIMLVVLMSF GVARQAILHP EEKPSWKLAR
1010 1020 1030 1040 1050
NIFYMPYWMI YGEVFADQID LYAMEINPPC GENLYDEEGK RLPPCIPGAW
1060 1070 1080 1090 1100
LTPALMACYL LVANILLVNL LIAVFNNTFF EVKSISNQVW KFQRYQLIMT
1110 1120 1130 1140 1150
FHDRPVLPPP MIILSHIYII IMRLSGRCRK KREGDQEERD RGLKLFLSDE
1160 1170 1180 1190 1200
ELKRLHEFEE QCVQEHFREK EDEQQSSSDE RIRVTSERVE NMSMRLEEIN
1210 1220 1230 1240 1250
ERETFMKTSL QTVDLRLAQL EELSNRMVNA LENLAGIDRS DLIQARSRAS
1260 1270 1280 1290 1300
SECEATYLLR QSSINSADGY SLYRYHFNGE ELLFEDTSLS TSPGTGVRKK
1310 1320 1330 1340 1350
TCSFRIKEEK DVKTHLVPEC QNSLHLSLGT STSATPDGSH LAVDDLKNAE
1360 1370 1380 1390
ESKLGPDIGI SKEDDERQTD SKKEETISPS LNKTDVIHGQ
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ7Z4N2 | TRPM1_HUMAN | Transient receptor potential cation... | TRPM1 LTRPC1, MLSN, MLSN1 | 1,603 | Annotation score: | ||
H0YM61 | H0YM61_HUMAN | Transient receptor potential cation... | TRPM1 | 505 | Annotation score: | ||
A0A0A0MTQ9 | A0A0A0MTQ9_HUMAN | Transient receptor potential cation... | TRPM1 | 1,526 | Annotation score: | ||
A0A0G2JMJ5 | A0A0G2JMJ5_HUMAN | Transient receptor potential cation... | TRPM1 | 1,603 | Annotation score: | ||
A0A0G2JMR4 | A0A0G2JMR4_HUMAN | Transient receptor potential cation... | TRPM1 | 1,625 | Annotation score: | ||
A0A0G2JN34 | A0A0G2JN34_HUMAN | Transient receptor potential cation... | TRPM1 | 1,642 | Annotation score: | ||
A0A0G2JPN6 | A0A0G2JPN6_HUMAN | Transient receptor potential cation... | TRPM1 | 1,603 | Annotation score: | ||
A0A0A0MTR0 | A0A0A0MTR0_HUMAN | Transient receptor potential cation... | TRPM1 | 229 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1390 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC009562 Genomic DNA No translation available. AC090829 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000558445; ENSP00000452946; ENSG00000134160 |
UCSCi | uc059hcq.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC009562 Genomic DNA No translation available. AC090829 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
MaxQBi | H0YKU7 |
PRIDEi | H0YKU7 |
ProteomicsDBi | 39759 |
Protocols and materials databases
Antibodypediai | 9410, 71 antibodies |
Genome annotation databases
Ensembli | ENST00000558445; ENSP00000452946; ENSG00000134160 |
UCSCi | uc059hcq.1, human |
Organism-specific databases
HGNCi | HGNC:7146, TRPM1 |
OpenTargetsi | ENSG00000134160 |
VEuPathDBi | HostDB:ENSG00000134160.13 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000155024 |
HOGENOMi | CLU_001390_4_1_1 |
Miscellaneous databases
ChiTaRSi | TRPM1, human |
Gene expression databases
Bgeei | ENSG00000134160, Expressed in pigmented layer of retina and 87 other tissues |
ExpressionAtlasi | H0YKU7, baseline and differential |
Family and domain databases
Gene3Di | 1.20.5.1010, 1 hit |
InterProi | View protein in InterPro IPR005821, Ion_trans_dom IPR029588, TRPM1 IPR041491, TRPM_SLOG IPR032415, TRPM_tetra IPR037162, TRPM_tetra_sf |
PANTHERi | PTHR13800:SF13, PTHR13800:SF13, 1 hit |
Pfami | View protein in Pfam PF00520, Ion_trans, 1 hit PF18139, LSDAT_euk, 1 hit PF16519, TRPM_tetra, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | H0YKU7_HUMAN | |
Accessioni | H0YKU7Primary (citable) accession number: H0YKU7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 22, 2012 |
Last sequence update: | February 22, 2012 | |
Last modified: | February 10, 2021 | |
This is version 62 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |