UniProtKB - H0YKC8 (H0YKC8_HUMAN)
Protein
Submitted name:
Calcium and integrin-binding family member 2
Gene
CIB2
Organism
Homo sapiens (Human)
Status
Functioni
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Calcium bindingi | 73 – 84 | PROSITE-ProRule annotationAdd BLAST | 12 | |
Calcium bindingi | 114 – 125 | PROSITE-ProRule annotationAdd BLAST | 12 |
GO - Molecular functioni
- calcium ion binding Source: InterPro
Keywordsi
Ligand | CalciumPROSITE-ProRule annotation, Metal-bindingARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Calcium and integrin-binding family member 2Imported |
Gene namesi | Name:CIB2Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:24579, CIB2 |
VEuPathDBi | HostDB:ENSG00000136425.12 |
Expressioni
Gene expression databases
Bgeei | ENSG00000136425, Expressed in right atrium auricular region and 232 other tissues |
ExpressionAtlasi | H0YKC8, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 23 – 58 | EF-handInterPro annotationAdd BLAST | 36 | |
Domaini | 60 – 95 | EF-handInterPro annotationAdd BLAST | 36 | |
Domaini | 101 – 136 | EF-handInterPro annotationAdd BLAST | 36 |
Phylogenomic databases
GeneTreei | ENSGT00940000157327 |
OMAi | SYVEFEH |
Family and domain databases
CDDi | cd00051, EFh, 1 hit |
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom |
Pfami | View protein in Pfam PF13499, EF-hand_7, 1 hit |
SMARTi | View protein in SMART SM00054, EFh, 2 hits |
SUPFAMi | SSF47473, SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 2 hits PS50222, EF_HAND_2, 3 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All
H0YKC8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDYRKSPIVH VPMSLIIQMP ELRENPFKER IVAAFSEDGE GNLTFNDFVD
60 70 80 90 100
MFSVLCESAP RELKANYAFK IYDFNTDNFI CKEDLELTLA RLTKSELDEE
110 120 130 140 150
EVVLVCDKVI EEADLDGDGK LGFADFEDMI AKAPDFLRCC HYRGRAWAGQ
160
SRAGRDVGAE APITRYL
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketO75838 | CIB2_HUMAN | Calcium and integrin-binding family... | CIB2 KIP2 | 187 | Annotation score: | ||
H0YKX8 | H0YKX8_HUMAN | Calcium and integrin-binding family... | CIB2 | 147 | Annotation score: | ||
H0YLL7 | H0YLL7_HUMAN | Calcium and integrin-binding family... | CIB2 | 126 | Annotation score: | ||
H0YND4 | H0YND4_HUMAN | Calcium and integrin-binding family... | CIB2 | 92 | Annotation score: | ||
H0YLX3 | H0YLX3_HUMAN | Calcium and integrin-binding family... | CIB2 | 54 | Annotation score: | ||
H0YML3 | H0YML3_HUMAN | Calcium and integrin-binding family... | CIB2 | 48 | Annotation score: | ||
A0A2R8Y4Y2 | A0A2R8Y4Y2_HUMAN | Calcium and integrin-binding family... | CIB2 | 63 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC090260 Genomic DNA No translation available. |
RefSeqi | XP_011519463.1, XM_011521161.2 |
Genome annotation databases
Ensembli | ENST00000560618; ENSP00000452752; ENSG00000136425 |
GeneIDi | 10518 |
UCSCi | uc059mbe.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC090260 Genomic DNA No translation available. |
RefSeqi | XP_011519463.1, XM_011521161.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | H0YKC8 |
PRIDEi | H0YKC8 |
ProteomicsDBi | 39619 |
Protocols and materials databases
Antibodypediai | 14987, 196 antibodies |
Genome annotation databases
Ensembli | ENST00000560618; ENSP00000452752; ENSG00000136425 |
GeneIDi | 10518 |
UCSCi | uc059mbe.1, human |
Organism-specific databases
CTDi | 10518 |
HGNCi | HGNC:24579, CIB2 |
OpenTargetsi | ENSG00000136425 |
VEuPathDBi | HostDB:ENSG00000136425.12 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000157327 |
OMAi | SYVEFEH |
Miscellaneous databases
BioGRID-ORCSi | 10518, 7 hits in 876 CRISPR screens |
ChiTaRSi | CIB2, human |
GenomeRNAii | 10518 |
Gene expression databases
Bgeei | ENSG00000136425, Expressed in right atrium auricular region and 232 other tissues |
ExpressionAtlasi | H0YKC8, baseline and differential |
Family and domain databases
CDDi | cd00051, EFh, 1 hit |
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom |
Pfami | View protein in Pfam PF13499, EF-hand_7, 1 hit |
SMARTi | View protein in SMART SM00054, EFh, 2 hits |
SUPFAMi | SSF47473, SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 2 hits PS50222, EF_HAND_2, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | H0YKC8_HUMAN | |
Accessioni | H0YKC8Primary (citable) accession number: H0YKC8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 22, 2012 |
Last sequence update: | February 22, 2012 | |
Last modified: | February 10, 2021 | |
This is version 58 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |