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UniProtKB - H0YJW3 (H0YJW3_HUMAN)
Protein
Submitted name:
Alpha-actinin-1
Gene
ACTN1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- actin binding Source: UniProtKB-KW
- calcium ion binding Source: InterPro
Keywordsi
Molecular function | Actin-bindingARBA annotation |
Ligand | CalciumARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Alpha-actinin-1 |
Gene namesi | Name:ACTN1 |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:163, ACTN1 |
VEuPathDBi | HostDB:ENSG00000072110 |
PTM / Processingi
Proteomic databases
MaxQBi | H0YJW3 |
PeptideAtlasi | H0YJW3 |
PRIDEi | H0YJW3 |
ProteomicsDBi | 39470 |
PTM databases
MetOSitei | H0YJW3 |
Expressioni
Gene expression databases
Bgeei | ENSG00000072110, Expressed in blood vessel layer and 248 other tissues |
ExpressionAtlasi | H0YJW3, baseline and differential |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 146 – 181 | EF-handInterPro annotationAdd BLAST | 36 |
Keywords - Domaini
RepeatARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000155548 |
HOGENOMi | CLU_038415_0_1_1 |
Family and domain databases
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR014837, EF-hand_Ca_insen IPR002048, EF_hand_dom IPR002017, Spectrin_repeat |
Pfami | View protein in Pfam PF08726, EFhand_Ca_insen, 1 hit PF00435, Spectrin, 1 hit |
SUPFAMi | SSF47473, SSF47473, 2 hits |
PROSITEi | View protein in PROSITE PS50222, EF_HAND_2, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 22 potential isoforms that are computationally mapped.Show allAlign All
H0YJW3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
XQALTEEHAR QQHNERLRKQ FGAQANVIGP WIQTKMEEIG RISIEMHGTL
60 70 80 90 100
EDQLSHLRQY EKSIVNYKPK IDQLEGDHQL IQEALIFDNK HTNYTMEHIR
110 120 130 140 150
VGWEQLLTTI ARTINEVENQ ILTRDAKGIS QEQMNEFRAS FNHFDRGEAE
160 170 180 190 200
FARIMSIVDP NRLGVVTFQA FIDFMSRETA DTDTADQVMA SFKILAGDKN
210 220 230 240 250
YITMDELRRE LPPDQAEYCI ARMAPYTGPD SVPGALDYMS FSTALYGESD
L
Computationally mapped potential isoform sequencesi
There are 22 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP12814 | ACTN1_HUMAN | Alpha-actinin-1 | ACTN1 | 892 | Annotation score: | ||
H9KV75 | H9KV75_HUMAN | Alpha-actinin-1 | ACTN1 | 822 | Annotation score: | ||
A0A7I2V4Y4 | A0A7I2V4Y4_HUMAN | Alpha-actinin-1 | ACTN1 | 895 | Annotation score: | ||
A0A804HII9 | A0A804HII9_HUMAN | Alpha-actinin-1 | ACTN1 | 913 | Annotation score: | ||
A0A804HIN7 | A0A804HIN7_HUMAN | Alpha-actinin-1 | ACTN1 | 883 | Annotation score: | ||
A0A804HJU8 | A0A804HJU8_HUMAN | Alpha-actinin-1 | ACTN1 | 874 | Annotation score: | ||
A0A804HK61 | A0A804HK61_HUMAN | Alpha-actinin-1 | ACTN1 | 886 | Annotation score: | ||
A0A804HKE2 | A0A804HKE2_HUMAN | Alpha-actinin-1 | ACTN1 | 922 | Annotation score: | ||
A0A804HL31 | A0A804HL31_HUMAN | Alpha-actinin-1 | ACTN1 | 827 | Annotation score: | ||
A0A804HLF4 | A0A804HLF4_HUMAN | Alpha-actinin-1 | ACTN1 | 826 | Annotation score: | ||
There are more potential isoformsShow all |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL117694 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000555075.5; ENSP00000452254.1; ENSG00000072110.16 |
UCSCi | uc059cte.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL117694 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
PTM databases
MetOSitei | H0YJW3 |
Proteomic databases
MaxQBi | H0YJW3 |
PeptideAtlasi | H0YJW3 |
PRIDEi | H0YJW3 |
ProteomicsDBi | 39470 |
Protocols and materials databases
Antibodypediai | 51, 491 antibodies from 39 providers |
Genome annotation databases
Ensembli | ENST00000555075.5; ENSP00000452254.1; ENSG00000072110.16 |
UCSCi | uc059cte.1, human |
Organism-specific databases
HGNCi | HGNC:163, ACTN1 |
OpenTargetsi | ENSG00000072110 |
VEuPathDBi | HostDB:ENSG00000072110 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000155548 |
HOGENOMi | CLU_038415_0_1_1 |
Miscellaneous databases
ChiTaRSi | ACTN1, human |
Gene expression databases
Bgeei | ENSG00000072110, Expressed in blood vessel layer and 248 other tissues |
ExpressionAtlasi | H0YJW3, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR014837, EF-hand_Ca_insen IPR002048, EF_hand_dom IPR002017, Spectrin_repeat |
Pfami | View protein in Pfam PF08726, EFhand_Ca_insen, 1 hit PF00435, Spectrin, 1 hit |
SUPFAMi | SSF47473, SSF47473, 2 hits |
PROSITEi | View protein in PROSITE PS50222, EF_HAND_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | H0YJW3_HUMAN | |
Accessioni | H0YJW3Primary (citable) accession number: H0YJW3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 22, 2012 |
Last sequence update: | February 22, 2012 | |
Last modified: | May 25, 2022 | |
This is version 63 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |