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Entry version 62 (02 Jun 2021)
Sequence version 1 (22 Feb 2012)
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Protein
Submitted name:

Fanconi anemia group M protein

Gene

FANCM

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Fanconi anemia group M proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FANCMImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:23168, FANCM

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000187790.10

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000187790

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
H0YJS3

MaxQB - The MaxQuant DataBase

More...
MaxQBi
H0YJS3

PeptideAtlas

More...
PeptideAtlasi
H0YJS3

PRoteomics IDEntifications database

More...
PRIDEi
H0YJS3

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
39430

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000187790, Expressed in sperm and 175 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
H0YJS3, baseline and differential

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1335 – 1418ERCC4InterPro annotationAdd BLAST84

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni949 – 992DisorderedSequence analysisAdd BLAST44
Regioni1034 – 1056DisorderedSequence analysisAdd BLAST23
Regioni1184 – 1325DisorderedSequence analysisAdd BLAST142

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi960 – 979Basic and acidic residuesSequence analysisAdd BLAST20
Compositional biasi1034 – 1055Acidic residuesSequence analysisAdd BLAST22
Compositional biasi1184 – 1199Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi1200 – 1283Polar residuesSequence analysisAdd BLAST84
Compositional biasi1299 – 1319Polar residuesSequence analysisAdd BLAST21

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156480

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006166, ERCC4_domain
IPR031879, FANCM-MHF-bd
IPR039686, FANCM/Mph1-like
IPR011335, Restrct_endonuc-II-like
IPR010994, RuvA_2-like

The PANTHER Classification System

More...
PANTHERi
PTHR14025:SF20, PTHR14025:SF20, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02732, ERCC4, 1 hit
PF16783, FANCM-MHF_bd, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00891, ERCC4, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47781, SSF47781, 1 hit
SSF52980, SSF52980, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

H0YJS3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
LECMFARTRS TSANGISAIQ QGDKNKKFVY SHPKLKKLEE VVIEHFKSWN
60 70 80 90 100
AENTTEKKRD ETRVMIFSSF RDSVQEIAEM LSQHQPIIRV MTFVGHASGK
110 120 130 140 150
STKGFTQKEQ LEIYNQSQSN KRSIYKAISS NRQVLHFYQR SPRMVPDGIN
160 170 180 190 200
PKLHKMFITH GVYEPEKPSR NLQRKSSIFS YRDGMRQSSL KKDWFLSEEE
210 220 230 240 250
FKLWNRLYRL RDSDEIKEIT LPQVQFSSLQ NEENKPAQES TTGIHQLSLS
260 270 280 290 300
EWRLWQDHPL PTHQVDHSDR CRHFIGLMQM IEGMRHEEGE CSYELEVESY
310 320 330 340 350
LQMEDVTSTF IAPRNESNNL ASDTFITHKK SSFIKNINQG SSSSVIESDE
360 370 380 390 400
ECAEIVKQTH IKPTKIVSLK KKVSKEIKKD QLKKENNHGI IDSVDNDRNS
410 420 430 440 450
TVENIFQEDL PNDKRTSDTD EIAATCTINE NVIKEPCVLL TECQFTNKST
460 470 480 490 500
SSLAGNVLDS GYNSFNDEKS VSSNLFLPFE EELYIVRTDD QFYNCHSLTK
510 520 530 540 550
EVLANVERFL SYSPPPLSGL SDLEYEIAKG TALENLLFLP CAEHLRSDKC
560 570 580 590 600
TCLLSHSAVN SQQNLELNSL KCINYPSEKS CLYDIPNDNI SDEPSLCDCD
610 620 630 640 650
VHKHNQNENL VPNNRVQIHR SPAQNLVGEN NHDVDNSDLP VLSTDQDESL
660 670 680 690 700
LLFEDVNTEF DDVSLSPLNS KSESLPVSDK TAISETPLVS QFLISDELLL
710 720 730 740 750
DNNSELQDQI TRDANSFKSR DQRGVQEEKV KNHEDIFDCS RDLFSVTFDL
760 770 780 790 800
GFCSPDSDDE ILEHTSDSNR PLDDLYGRYL EIKEISDANY VSNQALIPRD
810 820 830 840 850
HSKNFTSGTV IIPSNEDMQN PNYVHLPLSA AKNEELLSPG YSQFSLPVQK
860 870 880 890 900
KVMSTPLSKS NTLNSFSKIR KEILKTPDSS KEKVNLQRFK EALNSTFDYS
910 920 930 940 950
EFSLEKSKSS GPMYLHKSCH SVEDGQLLTS NESEDDEIFR RKVKRAKGNV
960 970 980 990 1000
LNSPEDQKNS EVDSPLHAVK KRRFPINRSE LSSSDESENF PKPCSQLEDF
1010 1020 1030 1040 1050
KVCNGNARRG IKVPKRQSHL KHVARKFLDD EAELSEEDAE YVSSDENDES
1060 1070 1080 1090 1100
ENEQDSSLLD FLNDETQLSQ AINDSEMRAI YMKSLRSPMM NNKYKMIHKT
1110 1120 1130 1140 1150
HKNINIFSQI PEQDETYLED SFCVDEEESC KGQSSEEEVC VDFNLITDDC
1160 1170 1180 1190 1200
FANSKKYKTR RAVMLKEMME QNCAHSKKKL SRIILPDDSS EEENNVNDKR
1210 1220 1230 1240 1250
ESNIAVNPST VKKNKQQDHC LNSVPSGSSA QSKVRSTPRV NPLAKQSKQT
1260 1270 1280 1290 1300
SLNLKDTISE VSDFKPQNHN EVQSTTPPFT TVDSQKDCRK FPVPQKDGSA
1310 1320 1330 1340 1350
LEDSSTSGAS CSKSRPHLAG THTSLRLPQE GKGTCILVGG HEITSGLEVI
1360 1370 1380 1390 1400
SSLRAIHGLQ VEVCPLNGCD YIVSNRMVVE RRSQSEMLNS VNKNKFIEQI
1410 1420 1430 1440 1450
QHLQSMFERI CVIVEKDREK TGDTSRMFRR TKSYDSLLTT LIGAGIRILF
1460 1470 1480 1490 1500
SSCQEETADL LKELSLVEQR KNVGIHVPTV VNSNKSEALQ FYLSIPNISY
1510 1520 1530 1540 1550
ITALNMCHQF SSVKRMANSS LQEISMYAQV THQKAEEIYR YIHYVFDIQM
1560
LPNDLNQDRL KSDI
Length:1,564
Mass (Da):178,142
Last modified:February 22, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7319DE72442920E9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8IYD8FANCM_HUMAN
Fanconi anemia group M protein
FANCM KIAA1596
2,048Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YJ14H0YJ14_HUMAN
Fanconi anemia group M protein
FANCM
1,016Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YJN7H0YJN7_HUMAN
Fanconi anemia group M protein
FANCM
135Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YJ45H0YJ45_HUMAN
Fanconi anemia group M protein
FANCM
106Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL121809 Genomic DNA No translation available.
KF455873 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000556250; ENSP00000452033; ENSG00000187790

UCSC genome browser

More...
UCSCi
uc059bdj.1, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL121809 Genomic DNA No translation available.
KF455873 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

EPDiH0YJS3
MaxQBiH0YJS3
PeptideAtlasiH0YJS3
PRIDEiH0YJS3
ProteomicsDBi39430

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
23452, 212 antibodies

Genome annotation databases

EnsembliENST00000556250; ENSP00000452033; ENSG00000187790
UCSCiuc059bdj.1, human

Organism-specific databases

HGNCiHGNC:23168, FANCM
OpenTargetsiENSG00000187790
VEuPathDBiHostDB:ENSG00000187790.10

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00940000156480

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
FANCM, human

Gene expression databases

BgeeiENSG00000187790, Expressed in sperm and 175 other tissues
ExpressionAtlasiH0YJS3, baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR006166, ERCC4_domain
IPR031879, FANCM-MHF-bd
IPR039686, FANCM/Mph1-like
IPR011335, Restrct_endonuc-II-like
IPR010994, RuvA_2-like
PANTHERiPTHR14025:SF20, PTHR14025:SF20, 2 hits
PfamiView protein in Pfam
PF02732, ERCC4, 1 hit
PF16783, FANCM-MHF_bd, 1 hit
SMARTiView protein in SMART
SM00891, ERCC4, 1 hit
SUPFAMiSSF47781, SSF47781, 1 hit
SSF52980, SSF52980, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH0YJS3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H0YJS3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: June 2, 2021
This is version 62 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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