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UniProtKB - H0YJI9 (H0YJI9_HUMAN)
Protein
Non-specific serine/threonine protein kinase
Gene
MARK3
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
- EC:2.7.11.1ARBA annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 85 | ATPPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- protein serine/threonine kinase activity Source: UniProtKB-EC
- protein serine kinase activity Source: RHEA
Keywordsi
Molecular function | TransferaseARBA annotation |
Ligand | ATP-bindingPROSITE-ProRule annotationARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Non-specific serine/threonine protein kinaseARBA annotation (EC:2.7.11.1ARBA annotation) |
Gene namesi | Name:MARK3Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6897, MARK3 |
Subcellular locationi
Other locations
- dendrite ARBA annotation
Other locations
- dendrite Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell projectionARBA annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 56 – 307 | Protein kinaseInterPro annotationAdd BLAST | 252 | |
Domaini | 326 – 365 | UBAInterPro annotationAdd BLAST | 40 | |
Domaini | 740 – 789 | KA1InterPro annotationAdd BLAST | 50 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 36 | DisorderedSequence analysisAdd BLAST | 36 | |
Regioni | 370 – 499 | DisorderedSequence analysisAdd BLAST | 130 | |
Regioni | 572 – 637 | DisorderedSequence analysisAdd BLAST | 66 | |
Regioni | 668 – 691 | DisorderedSequence analysisAdd BLAST | 24 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 14 – 28 | Basic and acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 371 – 402 | Polar residuesSequence analysisAdd BLAST | 32 | |
Compositional biasi | 472 – 499 | Polar residuesSequence analysisAdd BLAST | 28 | |
Compositional biasi | 614 – 637 | Polar residuesSequence analysisAdd BLAST | 24 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.ARBA annotation
Phylogenomic databases
GeneTreei | ENSGT00940000154862 |
HOGENOMi | CLU_078962_0_0_1 |
Family and domain databases
InterProi | View protein in InterPro IPR028375, KA1/Ssp2_C IPR001772, KA1_dom IPR011009, Kinase-like_dom_sf IPR033628, MARK3 IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS IPR015940, UBA |
PANTHERi | PTHR24346:SF1, PTHR24346:SF1, 1 hit |
Pfami | View protein in Pfam PF02149, KA1, 1 hit PF00069, Pkinase, 1 hit PF00627, UBA, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit SM00165, UBA, 1 hit |
SUPFAMi | SSF103243, SSF103243, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50032, KA1, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit PS50030, UBA, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 35 potential isoforms that are computationally mapped.Show allAlign All
H0YJI9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSTRTPLPTV NERDTENHTS HGDGRQEVTS RTSRSGARCR NSIASCADEQ
60 70 80 90 100
PHIGNYRLLK TIGKGNFAKV KLARHILTGR EVAIKIIDKT QLNPTSLQKL
110 120 130 140 150
FREVRIMKIL NHPNIVKLFE VIETEKTLYL IMEYASGGEV FDYLVAHGRM
160 170 180 190 200
KEKEARSKFR QIVSAVQYCH QKRIVHRDLK AENLLLDADM NIKIADFGFS
210 220 230 240 250
NEFTVGGKLD TFCGSPPYAA PELFQGKKYD GPEVDVWSLG VILYTLVSGS
260 270 280 290 300
LPFDGQNLKE LRERVLRGKY RIPFYMSTDC ENLLKRFLVL NPIKRGTLEQ
310 320 330 340 350
IMKDRWINAG HEEDELKPFV EPELDISDQK RIDIMVGMGY SQEEIQESLS
360 370 380 390 400
KMKYDEITAT YLLLGRKSSE VRPSSDLNNS TGQSPHHKVQ RSVSSSQKQR
410 420 430 440 450
RYSDHAGPAI PSVVAYPKRS QTSTADSDLK EDGISSRKSS GSAVGGKGIA
460 470 480 490 500
PASPMLGNAS NPNKADIPER KKSSTVPSSN TASGGMTRRN TYVCSERTTA
510 520 530 540 550
DRHSVIQNGK ENSLTEMFAY AASPASVCTS TCRLRHQKSM SMSASGHPKM
560 570 580 590 600
MLPPIDSEGD NFKAITIPDQ RTPVASTHSI SSAATPDRIR FPRGTASRST
610 620 630 640 650
FHGQPRERRT ATYNGPPASP SLSHEATPLS QTRSRGSTNL FSKLTSKLTR
660 670 680 690 700
RNMSFRFIKR LPTEYERNGR YEGSSRNVSA EQKDENKEAK PRSLRFTWSM
710 720 730 740 750
KTTSSMDPGD MMREIRKVLD ANNCDYEQRE RFLLFCVHGD GHAENLVQWE
760 770 780
MEVCKLPRLS LNGVRFKRIS GTSIAFKNIA SKIANELKL
Computationally mapped potential isoform sequencesi
There are 35 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP27448 | MARK3_HUMAN | MAP/microtubule affinity-regulating... | MARK3 CTAK1, EMK2 | 753 | Annotation score: | ||
H0YNV4 | H0YNV4_HUMAN | Non-specific serine/threonine prote... | MARK3 | 643 | Annotation score: | ||
J3KNR0 | J3KNR0_HUMAN | Non-specific serine/threonine prote... | MARK3 hCG_25498 | 776 | Annotation score: | ||
A0A7I2YQF7 | A0A7I2YQF7_HUMAN | Non-specific serine/threonine prote... | MARK3 | 738 | Annotation score: | ||
A0A7I2V2N8 | A0A7I2V2N8_HUMAN | Non-specific serine/threonine prote... | MARK3 | 726 | Annotation score: | ||
A0A7I2V2U9 | A0A7I2V2U9_HUMAN | Non-specific serine/threonine prote... | MARK3 | 790 | Annotation score: | ||
A0A7I2V3I9 | A0A7I2V3I9_HUMAN | Non-specific serine/threonine prote... | MARK3 | 682 | Annotation score: | ||
A0A7I2V409 | A0A7I2V409_HUMAN | Non-specific serine/threonine prote... | MARK3 | 796 | Annotation score: | ||
A0A7I2V4K8 | A0A7I2V4K8_HUMAN | Non-specific serine/threonine prote... | MARK3 | 781 | Annotation score: | ||
H0YIY6 | H0YIY6_HUMAN | Non-specific serine/threonine prote... | MARK3 | 505 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL133367 Genomic DNA No translation available. KF456011 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000556744; ENSP00000451623; ENSG00000075413 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL133367 Genomic DNA No translation available. KF456011 Genomic DNA No translation available. |
3D structure databases
SMRi | H0YJI9 |
ModBasei | Search... |
Genome annotation databases
Ensembli | ENST00000556744; ENSP00000451623; ENSG00000075413 |
Organism-specific databases
HGNCi | HGNC:6897, MARK3 |
OpenTargetsi | ENSG00000075413 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000154862 |
HOGENOMi | CLU_078962_0_0_1 |
Miscellaneous databases
ChiTaRSi | MARK3, human |
Family and domain databases
InterProi | View protein in InterPro IPR028375, KA1/Ssp2_C IPR001772, KA1_dom IPR011009, Kinase-like_dom_sf IPR033628, MARK3 IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS IPR015940, UBA |
PANTHERi | PTHR24346:SF1, PTHR24346:SF1, 1 hit |
Pfami | View protein in Pfam PF02149, KA1, 1 hit PF00069, Pkinase, 1 hit PF00627, UBA, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit SM00165, UBA, 1 hit |
SUPFAMi | SSF103243, SSF103243, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50032, KA1, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit PS50030, UBA, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | H0YJI9_HUMAN | |
Accessioni | H0YJI9Primary (citable) accession number: H0YJI9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 7, 2021 |
Last sequence update: | April 7, 2021 | |
Last modified: | January 19, 2022 | |
This is version 4 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |