SPTB

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Spectrin beta chain, erythrocyticImported
Gene namesⁱ	Name:SPTBImported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 14

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000070182.17
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11274 SPTB

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000070182

OpenTargetsⁱ

ENSG00000070182

PTM / Processingⁱ

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	H0YJE6
PeptideAtlas More...PeptideAtlasⁱ	H0YJE6
PRIDEⁱ	H0YJE6

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000070182 Expressed in 165 organ(s), highest expression level in gastrocnemius
ExpressionAtlasⁱ	H0YJE6 baseline and differential

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	H0YJE6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	885 – 988	PHInterPro annotationAdd BLAST		104

Coiled coil

Feature key	Position(s)	DescriptionActions	Length
Coiled coilⁱ	79 – 99	Sequence analysisAdd BLAST	21
Coiled coilⁱ	203 – 230	Sequence analysisAdd BLAST	28
Coiled coilⁱ	642 – 666	Sequence analysisAdd BLAST	25

Keywords - Domainⁱ

Coiled coilSequence analysis

Phylogenomic databases

eggNOGⁱ	KOG0517 Eukaryota COG5069 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118813

Family and domain databases

InterProⁱ	View protein in InterPro IPR001849 PH_domain IPR018159 Spectrin/alpha-actinin IPR002017 Spectrin_repeat
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00435 Spectrin, 7 hits
SMARTⁱ	View protein in SMART SM00233 PH, 1 hit SM00150 SPEC, 7 hits
PROSITEⁱ	View protein in PROSITE PS50003 PH_DOMAIN, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Fragment.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

H0YJE6-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
GKQLMDEKPQ FTALVSQKLE ALHRLWDELQ ATTKEKTQHL SAARSSDLRL 
        60         70         80         90        100
QTHADLNKWI SAMEDQLRSD DPGKDLTSVN RMLAKLKRVE DQVNVRKEEL 
       110        120        130        140        150
GELFAQVPSM GEEGGDADLS IEKRFLDLLE PLGRRKKQLE SSRAKLQISR 
       160        170        180        190        200
DLEDETLWVE ERLPLAQSAD YGTNLQTVQL FMKKNQTLQN EILGHTPRVE 
       210        220        230        240        250
DVLQRGQQLV EAAEIDCQDL EERLGHLQSS WDRLREAAAG RLQRLRDANE 
       260        270        280        290        300
AQQYYLDADE AEAWIGEQEL YVISDEIPKD EEGAIVMLKR HLRQQRAVED 
       310        320        330        340        350
YGRNIKQLAS RAQGLLSAGH PEGEQIIRLQ GQVDKHYAGL KDVAEERKRK 
       360        370        380        390        400
LENMYHLFQL KRETDDLEQW ISEKELVASS PEMGQDFDHV TLLRDKFRDF 
       410        420        430        440        450
ARETGAIGQE RVDNVNAFIE RLIDAGHSEA ATIAEWKDGL NEMWADLLEL 
       460        470        480        490        500
IDTRMQLLAA SYDLHRYFYT GAEILGLIDE KHRELPEDVG LDASTAESFH 
       510        520        530        540        550
RVHTAFEREL HLLGVQVQQF QDVATRLQTA YAGEKAEAIQ NKEQEVSAAW 
       560        570        580        590        600
QALLDACAGR RTQLVDTADK FRFFSMARDL LSWMESIIRQ IETQERPRDV 
       610        620        630        640        650
SSVELLMKYH QGINAEIETR SKNFSACLEL GESLLQRQHQ ASEEIREKLQ 
       660        670        680        690        700
QVMSRRKEMN EKWEARWERL RMLLEVCQFS RDASVAEAWL IAQEPYLASG 
       710        720        730        740        750
DFGHTVDSVE KLIKRHEAFE KSTASWAERF AALEKPTTLE LKERQIAERP 
       760        770        780        790        800
AEETGPQEEE GETAGEAPVS HHAATERTSP GEEEGTWPQN LQQPPPPGQH 
       810        820        830        840        850
KDGQKSTGDE RPTTEPLFKV LDTPLSEGDE PATLPAPRDH GQSVQMEGYL 
       860        870        880        890        900
GRKHDLEGPN KKASNSKGEE GEERRETEEE DEEEEETESV AVEMQQHASH 
       910        920        930        940        950
VSWNNLYCVL RNSELTFYKD AKNLALGMPY HGEEPLALRH AICEIAANYK 
       960        970        980        990       1000
KKKHVFKLRL SNGSEWLFHG KDEEEMLSWL QGVSTAINES QSIRVKAQSL 
      1010       1020 
PLPSLSGPDA SLGKKDKEKR FSFFPKKK

Length:1,028

Mass (Da):117,489

Last modified:February 22, 2012 - v1

Checksum:ⁱA00D1D736905367E

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	P11277	SPTB1_HUMAN		Spectrin beta chain, erythrocytic Spectrin beta chain, erythrocytic (Beta-I spectrin)	SPTB SPTB1	2,137	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Non-terminal residueⁱ	1	Imported		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL121774 Genomic DNA No translation available. AL135745 Genomic DNA No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AL121774 Genomic DNA No translation available.
AL135745 Genomic DNA No translation available.

Genome annotation databases

Ensemblⁱ	ENST00000553938; ENSP00000451324; ENSG00000070182
UCSC genome browser More...UCSCⁱ	uc059cko.1 human

Protein	Similar proteins		Species	Score	Length	Source
H0YJE6	SPTB isoform 4 (Fragment)		PONAB		1029	UniRef90_H0YJE6
Beta I spectrin form betaI sigma3 (Fragment)		HUMAN		1028
SPTB isoform 4 (Fragment)		PANTR		1025
Uncharacterized protein		MACMU		1024

Protein	Similar proteins		Species	Score	Length	Source
H0YJE6	SPTB isoform 4 (Fragment)		PONAB		1029	UniRef50_H0YJE6
Beta I spectrin form betaI sigma3 (Fragment)		HUMAN		1028
SPTB isoform 4 (Fragment)		PANTR		1025
Uncharacterized protein		MACMU		1024
Spectrin, beta, erythrocytic (Fragment)		Nothobranchius kadleci		847

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL121774 Genomic DNA No translation available. AL135745 Genomic DNA No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AL121774 Genomic DNA No translation available.
AL135745 Genomic DNA No translation available.

3D structure databases

ProteinModelPortalⁱ	H0YJE6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

MaxQBⁱ	H0YJE6
PeptideAtlasⁱ	H0YJE6
PRIDEⁱ	H0YJE6

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000553938; ENSP00000451324; ENSG00000070182
UCSCⁱ	uc059cko.1 human

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000070182.17
HGNCⁱ	HGNC:11274 SPTB
OpenTargetsⁱ	ENSG00000070182
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0517 Eukaryota COG5069 LUCA
GeneTreeⁱ	ENSGT00760000118813

Miscellaneous databases

ChiTaRSⁱ	SPTB human

ChiTaRSⁱ

SPTB human

Gene expression databases

Bgeeⁱ	ENSG00000070182 Expressed in 165 organ(s), highest expression level in gastrocnemius
ExpressionAtlasⁱ	H0YJE6 baseline and differential

Family and domain databases

InterProⁱ	View protein in InterPro IPR001849 PH_domain IPR018159 Spectrin/alpha-actinin IPR002017 Spectrin_repeat
Pfamⁱ	View protein in Pfam PF00435 Spectrin, 7 hits
SMARTⁱ	View protein in SMART SM00233 PH, 1 hit SM00150 SPEC, 7 hits
PROSITEⁱ	View protein in PROSITE PS50003 PH_DOMAIN, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	H0YJE6_HUMAN
Accessionⁱ	H0YJE6Primary (citable) accession number: H0YJE6
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	February 22, 2012
	Last sequence update:	February 22, 2012
	Last modified:	September 12, 2018
	This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

UniProtKB

UniParc

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UniRef

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Annotation systems

Supporting data

UniProtKB - H0YJE6 (H0YJE6_HUMAN)

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Spectrin beta chain, erythrocytic

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<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Names & Taxonomyⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ