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Protein
Submitted name:

Spectrin beta chain, erythrocytic

Gene

SPTB

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
Spectrin beta chain, erythrocyticImported
Gene namesi
Name:SPTBImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000070182.17
HGNCiHGNC:11274 SPTB

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000070182

PTM / Processingi

Proteomic databases

MaxQBiH0YJE6
PeptideAtlasiH0YJE6
PRIDEiH0YJE6

Expressioni

Gene expression databases

BgeeiENSG00000070182 Expressed in 165 organ(s), highest expression level in gastrocnemius
ExpressionAtlasiH0YJE6 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliH0YJE6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini885 – 988PHInterPro annotationAdd BLAST104

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili79 – 99Sequence analysisAdd BLAST21
Coiled coili203 – 230Sequence analysisAdd BLAST28
Coiled coili642 – 666Sequence analysisAdd BLAST25

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0517 Eukaryota
COG5069 LUCA
GeneTreeiENSGT00760000118813

Family and domain databases

InterProiView protein in InterPro
IPR001849 PH_domain
IPR018159 Spectrin/alpha-actinin
IPR002017 Spectrin_repeat
PfamiView protein in Pfam
PF00435 Spectrin, 7 hits
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00150 SPEC, 7 hits
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

H0YJE6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
GKQLMDEKPQ FTALVSQKLE ALHRLWDELQ ATTKEKTQHL SAARSSDLRL
60 70 80 90 100
QTHADLNKWI SAMEDQLRSD DPGKDLTSVN RMLAKLKRVE DQVNVRKEEL
110 120 130 140 150
GELFAQVPSM GEEGGDADLS IEKRFLDLLE PLGRRKKQLE SSRAKLQISR
160 170 180 190 200
DLEDETLWVE ERLPLAQSAD YGTNLQTVQL FMKKNQTLQN EILGHTPRVE
210 220 230 240 250
DVLQRGQQLV EAAEIDCQDL EERLGHLQSS WDRLREAAAG RLQRLRDANE
260 270 280 290 300
AQQYYLDADE AEAWIGEQEL YVISDEIPKD EEGAIVMLKR HLRQQRAVED
310 320 330 340 350
YGRNIKQLAS RAQGLLSAGH PEGEQIIRLQ GQVDKHYAGL KDVAEERKRK
360 370 380 390 400
LENMYHLFQL KRETDDLEQW ISEKELVASS PEMGQDFDHV TLLRDKFRDF
410 420 430 440 450
ARETGAIGQE RVDNVNAFIE RLIDAGHSEA ATIAEWKDGL NEMWADLLEL
460 470 480 490 500
IDTRMQLLAA SYDLHRYFYT GAEILGLIDE KHRELPEDVG LDASTAESFH
510 520 530 540 550
RVHTAFEREL HLLGVQVQQF QDVATRLQTA YAGEKAEAIQ NKEQEVSAAW
560 570 580 590 600
QALLDACAGR RTQLVDTADK FRFFSMARDL LSWMESIIRQ IETQERPRDV
610 620 630 640 650
SSVELLMKYH QGINAEIETR SKNFSACLEL GESLLQRQHQ ASEEIREKLQ
660 670 680 690 700
QVMSRRKEMN EKWEARWERL RMLLEVCQFS RDASVAEAWL IAQEPYLASG
710 720 730 740 750
DFGHTVDSVE KLIKRHEAFE KSTASWAERF AALEKPTTLE LKERQIAERP
760 770 780 790 800
AEETGPQEEE GETAGEAPVS HHAATERTSP GEEEGTWPQN LQQPPPPGQH
810 820 830 840 850
KDGQKSTGDE RPTTEPLFKV LDTPLSEGDE PATLPAPRDH GQSVQMEGYL
860 870 880 890 900
GRKHDLEGPN KKASNSKGEE GEERRETEEE DEEEEETESV AVEMQQHASH
910 920 930 940 950
VSWNNLYCVL RNSELTFYKD AKNLALGMPY HGEEPLALRH AICEIAANYK
960 970 980 990 1000
KKKHVFKLRL SNGSEWLFHG KDEEEMLSWL QGVSTAINES QSIRVKAQSL
1010 1020
PLPSLSGPDA SLGKKDKEKR FSFFPKKK
Length:1,028
Mass (Da):117,489
Last modified:February 22, 2012 - v1
Checksum:iA00D1D736905367E
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P11277SPTB1_HUMAN
Spectrin beta chain, erythrocytic
SPTB SPTB1
2,137Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL121774 Genomic DNA No translation available.
AL135745 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000553938; ENSP00000451324; ENSG00000070182
UCSCiuc059cko.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL121774 Genomic DNA No translation available.
AL135745 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliH0YJE6
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiH0YJE6
PeptideAtlasiH0YJE6
PRIDEiH0YJE6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000553938; ENSP00000451324; ENSG00000070182
UCSCiuc059cko.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000070182.17
HGNCiHGNC:11274 SPTB
OpenTargetsiENSG00000070182
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0517 Eukaryota
COG5069 LUCA
GeneTreeiENSGT00760000118813

Miscellaneous databases

ChiTaRSiSPTB human

Gene expression databases

BgeeiENSG00000070182 Expressed in 165 organ(s), highest expression level in gastrocnemius
ExpressionAtlasiH0YJE6 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR001849 PH_domain
IPR018159 Spectrin/alpha-actinin
IPR002017 Spectrin_repeat
PfamiView protein in Pfam
PF00435 Spectrin, 7 hits
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00150 SPEC, 7 hits
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiH0YJE6_HUMAN
AccessioniPrimary (citable) accession number: H0YJE6
Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: September 12, 2018
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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