UniProtKB - H0YIZ0 (H0YIZ0_HUMAN)
Protein
Glycine hydroxymethyltransferase
Gene
SHMT2
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
- (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serineARBA annotationEC:2.1.2.1ARBA annotation
Cofactori
pyridoxal 5'-phosphateARBA annotation
: tetrahydrofolate interconversion Pathwayi
This protein is involved in the pathway tetrahydrofolate interconversion, which is part of One-carbon metabolism.ARBA annotationView all proteins of this organism that are known to be involved in the pathway tetrahydrofolate interconversion and in One-carbon metabolism.
GO - Molecular functioni
- glycine hydroxymethyltransferase activity Source: UniProtKB-EC
- pyridoxal phosphate binding Source: InterPro
GO - Biological processi
- glycine biosynthetic process from serine Source: InterPro
- tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Keywordsi
Molecular function | TransferaseARBA annotation |
Biological process | One-carbon metabolismARBA annotation |
Ligand | Pyridoxal phosphateARBA annotation |
Enzyme and pathway databases
UniPathwayi | UPA00193 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:SHMT2Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:10852, SHMT2 |
VEuPathDBi | HostDB:ENSG00000182199.10 |
PTM / Processingi
Proteomic databases
MaxQBi | H0YIZ0 |
PeptideAtlasi | H0YIZ0 |
PRIDEi | H0YIZ0 |
ProteomicsDBi | 39153 |
Expressioni
Gene expression databases
Bgeei | ENSG00000182199, Expressed in thoracic mammary gland and 242 other tissues |
ExpressionAtlasi | H0YIZ0, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 2 – 248 | SHMTInterPro annotationAdd BLAST | 247 |
Sequence similaritiesi
Belongs to the SHMT family.ARBA annotation
Phylogenomic databases
GeneTreei | ENSGT00390000002762 |
Family and domain databases
Gene3Di | 3.40.640.10, 1 hit 3.90.1150.10, 1 hit |
InterProi | View protein in InterPro IPR015424, PyrdxlP-dep_Trfase IPR015422, PyrdxlP-dep_Trfase_dom1 IPR015421, PyrdxlP-dep_Trfase_major IPR001085, Ser_HO-MeTrfase IPR019798, Ser_HO-MeTrfase_PLP_BS IPR039429, SHMT-like_dom |
PANTHERi | PTHR11680, PTHR11680, 1 hit |
Pfami | View protein in Pfam PF00464, SHMT, 1 hit |
SUPFAMi | SSF53383, SSF53383, 1 hit |
PROSITEi | View protein in PROSITE PS00096, SHMT, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 14 potential isoforms that are computationally mapped.Show allAlign All
H0YIZ0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
XGLIDYNQLA LTARLFRPRL IIAGTSAYAR LIDYARMREV CDEVKAHLLA
60 70 80 90 100
DMAHISGLVA AKVIPSPFKH ADIVTTTTHK TLRGARSGLI FYRKGVKAVD
110 120 130 140 150
PKTGREIPYT FEDRINFAVF PSLQGGPHNH AIAAVAVALK QACTPMFREY
160 170 180 190 200
SLQVLKNARA MADALLERGY SLVSGGTDNH LVLVDLRPKG LDGARAERVL
210 220 230 240 250
ELVSITANKN TCPGDRSAIT PGGLRLGAPA LTSRQFREDD FRRVVDFIDE
260
GVNIGLEVKS KTGE
Computationally mapped potential isoform sequencesi
There are 14 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP34897 | GLYM_HUMAN | Serine hydroxymethyltransferase, mi... | SHMT2 | 504 | Annotation score: | ||
G3V5L0 | G3V5L0_HUMAN | Glycine hydroxymethyltransferase | SHMT2 | 215 | Annotation score: | ||
G3V241 | G3V241_HUMAN | Glycine hydroxymethyltransferase | SHMT2 | 142 | Annotation score: | ||
G3V2W0 | G3V2W0_HUMAN | Glycine hydroxymethyltransferase | SHMT2 | 160 | Annotation score: | ||
G3V4T0 | G3V4T0_HUMAN | Glycine hydroxymethyltransferase | SHMT2 | 149 | Annotation score: | ||
G3V4X0 | G3V4X0_HUMAN | Glycine hydroxymethyltransferase | SHMT2 | 159 | Annotation score: | ||
G3V3Y8 | G3V3Y8_HUMAN | Glycine hydroxymethyltransferase | SHMT2 | 147 | Annotation score: | ||
G3V4W5 | G3V4W5_HUMAN | Glycine hydroxymethyltransferase | SHMT2 | 237 | Annotation score: | ||
G3V540 | G3V540_HUMAN | Glycine hydroxymethyltransferase | SHMT2 | 192 | Annotation score: | ||
G3V2E4 | G3V2E4_HUMAN | Glycine hydroxymethyltransferase | SHMT2 | 171 | Annotation score: | ||
There are more potential isoformsShow all |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC137834 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000557529; ENSP00000450490; ENSG00000182199 |
UCSCi | uc058puo.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC137834 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
Proteomic databases
MaxQBi | H0YIZ0 |
PeptideAtlasi | H0YIZ0 |
PRIDEi | H0YIZ0 |
ProteomicsDBi | 39153 |
Protocols and materials databases
Antibodypediai | 16145, 232 antibodies |
Genome annotation databases
Ensembli | ENST00000557529; ENSP00000450490; ENSG00000182199 |
UCSCi | uc058puo.1, human |
Organism-specific databases
HGNCi | HGNC:10852, SHMT2 |
OpenTargetsi | ENSG00000182199 |
VEuPathDBi | HostDB:ENSG00000182199.10 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00390000002762 |
Enzyme and pathway databases
UniPathwayi | UPA00193 |
Miscellaneous databases
ChiTaRSi | SHMT2, human |
Gene expression databases
Bgeei | ENSG00000182199, Expressed in thoracic mammary gland and 242 other tissues |
ExpressionAtlasi | H0YIZ0, baseline and differential |
Family and domain databases
Gene3Di | 3.40.640.10, 1 hit 3.90.1150.10, 1 hit |
InterProi | View protein in InterPro IPR015424, PyrdxlP-dep_Trfase IPR015422, PyrdxlP-dep_Trfase_dom1 IPR015421, PyrdxlP-dep_Trfase_major IPR001085, Ser_HO-MeTrfase IPR019798, Ser_HO-MeTrfase_PLP_BS IPR039429, SHMT-like_dom |
PANTHERi | PTHR11680, PTHR11680, 1 hit |
Pfami | View protein in Pfam PF00464, SHMT, 1 hit |
SUPFAMi | SSF53383, SSF53383, 1 hit |
PROSITEi | View protein in PROSITE PS00096, SHMT, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | H0YIZ0_HUMAN | |
Accessioni | H0YIZ0Primary (citable) accession number: H0YIZ0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 22, 2012 |
Last sequence update: | February 22, 2012 | |
Last modified: | February 10, 2021 | |
This is version 59 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |