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Protein

Non-specific serine/threonine protein kinase

Gene

MARK3

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.SAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinaseSAAS annotation, Transferase
LigandATP-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiH0YIY6

Names & Taxonomyi

Protein namesi
Recommended name:
Non-specific serine/threonine protein kinaseSAAS annotation (EC:2.7.11.1SAAS annotation)
Gene namesi
Name:MARK3Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000075413.17
HGNCiHGNC:6897 MARK3

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000075413

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_500354596318 – 505Non-specific serine/threonine protein kinaseSequence analysisAdd BLAST488

Proteomic databases

PeptideAtlasiH0YIY6
PRIDEiH0YIY6

Expressioni

Gene expression databases

BgeeiENSG00000075413 Expressed in 228 organ(s), highest expression level in cerebellar hemisphere
ExpressionAtlasiH0YIY6 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliH0YIY6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 75Protein kinaseInterPro annotationAdd BLAST75
Domaini94 – 133UBAInterPro annotationAdd BLAST40
Domaini456 – 505KA1InterPro annotationAdd BLAST50

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG0586 Eukaryota
ENOG410XNQ0 LUCA
GeneTreeiENSGT00900000140806

Family and domain databases

InterProiView protein in InterPro
IPR028375 KA1/Ssp2_C
IPR001772 KA1_dom
IPR011009 Kinase-like_dom_sf
IPR033624 MARK/par1
IPR033628 MARK3
IPR000719 Prot_kinase_dom
IPR015940 UBA
PANTHERiPTHR24346 PTHR24346, 1 hit
PTHR24346:SF1 PTHR24346:SF1, 1 hit
PfamiView protein in Pfam
PF02149 KA1, 1 hit
PF00069 Pkinase, 1 hit
PF00627 UBA, 1 hit
SMARTiView protein in SMART
SM00165 UBA, 1 hit
SUPFAMiSSF103243 SSF103243, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50032 KA1, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS50030 UBA, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.iShow all

H0YIY6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
XVDVWSLGVI LYTLVSGSLP FDGQNLKELR ERVLRGKYRI PFYMSTDCEN
60 70 80 90 100
LLKRFLVLNP IKRGTLEQIM KDRWINAGHE EDELKPFVEP ELDISDQKRI
110 120 130 140 150
DIMVGMGYSQ EEIQESLSKM KYDEITATYL LLGRKSSEVR PSSDLNNSTG
160 170 180 190 200
QSPHHKVQRS VSSSQKQRRY SDHAGPAIPS VVAYPKRSQT STADSDLKED
210 220 230 240 250
GISSRKSSGS AVGGKGIAPA SPMLGNASNP NKADIPERKK SSTVPSSNTA
260 270 280 290 300
SGGMTRRNTY VCSERTTADR HSVIQNGKEN STIPDQRTPV ASTHSISSAA
310 320 330 340 350
TPDRIRFPRG TASRSTFHGQ PRERRTATYN GPPASPSLSH EATPLSQTRS
360 370 380 390 400
RGSTNLFSKL TSKLTRRNMS FRFIKRLPTE YERNGRYEGS SRNVSAEQKD
410 420 430 440 450
ENKEAKPRSL RFTWSMKTTS SMDPGDMMRE IRKVLDANNC DYEQRERFLL
460 470 480 490 500
FCVHGDGHAE NLVQWEMEVC KLPRLSLNGV RFKRISGTSI AFKNIASKIA

NELKL
Length:505
Mass (Da):56,614
Last modified:October 29, 2014 - v2
Checksum:i9E5BF3354D6C8D5C
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P27448MARK3_HUMAN
MAP/microtubule affinity-regulating...
MARK3 CTAK1, EMK2
753Annotation score:
J3KNR0J3KNR0_HUMAN
Non-specific serine/threonine prote...
MARK3 hCG_25498
776Annotation score:
A0A0A0MSZ1A0A0A0MSZ1_HUMAN
Non-specific serine/threonine prote...
MARK3 hCG_25498
752Annotation score:
H0YNV4H0YNV4_HUMAN
MAP/microtubule affinity-regulating...
MARK3
178Annotation score:
H0YKJ3H0YKJ3_HUMAN
MAP/microtubule affinity-regulating...
MARK3
129Annotation score:
A2SY06A2SY06_HUMAN
MAP/microtubule affinity-regulating...
MARK3
331Annotation score:
H0YKP9H0YKP9_HUMAN
MAP/microtubule affinity-regulating...
MARK3
222Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL133367 Genomic DNA No translation available.
KF456011 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000554627; ENSP00000450460; ENSG00000075413
UCSCiuc059fqm.1 human

Similar proteinsi

Entry informationi

Entry nameiH0YIY6_HUMAN
AccessioniPrimary (citable) accession number: H0YIY6
Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: October 29, 2014
Last modified: September 12, 2018
This is version 58 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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