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Protein
Submitted name:

Signal transducer and activator of transcription 6

Gene

STAT6

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Signal transducer and activator of transcription 6Imported
Gene namesi
Name:STAT6Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000166888.10
HGNCiHGNC:11368 STAT6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000166888

PTM / Processingi

Proteomic databases

MaxQBiH0YIY2
PeptideAtlasiH0YIY2
PRIDEiH0YIY2

Expressioni

Gene expression databases

BgeeiENSG00000166888 Expressed in 228 organ(s), highest expression level in esophagus
ExpressionAtlasiH0YIY2 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliH0YIY2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini83 – 122STAT6_CInterPro annotationAdd BLAST40

Phylogenomic databases

eggNOGiKOG3667 Eukaryota
ENOG410XPN8 LUCA
GeneTreeiENSGT00760000119236

Family and domain databases

Gene3Di3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR036860 SH2_dom_sf
IPR001217 STAT
IPR028187 STAT6_C
PANTHERiPTHR11801 PTHR11801, 1 hit
PfamiView protein in Pfam
PF14596 STAT6_C, 1 hit
SUPFAMiSSF55550 SSF55550, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 13 potential isoforms that are computationally mapped.Show allAlign All

H0YIY2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
IAHVIRGQDG SPQIENIQPF SAKDLSIRSL GDRIRDLAQL KNLYPKKPKD
60 70 80 90 100
EAFRSHYKPE QMGKDGRGYV PATIKMTVER DQPLPTPELQ MPTMVPSYDL
110 120 130 140 150
GMAPDSSMSM QLGPDMVCTH HTLTPSPRIK ASPQKNQSTC CQPSRSLTCR

CPPAW
Length:155
Mass (Da):17,302
Last modified:February 22, 2012 - v1
Checksum:iD5406ECD395BC0E2
GO

Computationally mapped potential isoform sequencesi

There are 13 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P42226STAT6_HUMAN
Signal transducer and activator of ...
STAT6
847Annotation score:
A0A1W2PNW1A0A1W2PNW1_HUMAN
Signal transducer and activator of ...
STAT6
679Annotation score:
G3V2X7G3V2X7_HUMAN
Signal transducer and activator of ...
STAT6
154Annotation score:
H0YJH6H0YJH6_HUMAN
Signal transducer and activator of ...
STAT6
290Annotation score:
G3V3E9G3V3E9_HUMAN
Signal transducer and activator of ...
STAT6
103Annotation score:
G3V370G3V370_HUMAN
Signal transducer and activator of ...
STAT6
154Annotation score:
G3V2M3G3V2M3_HUMAN
Signal transducer and activator of ...
STAT6
74Annotation score:
G3V568G3V568_HUMAN
Signal transducer and activator of ...
STAT6
144Annotation score:
G3V5K5G3V5K5_HUMAN
Signal transducer and activator of ...
STAT6
159Annotation score:
G3V2L2G3V2L2_HUMAN
Signal transducer and activator of ...
STAT6
64Annotation score:
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1
Non-terminal residuei155Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC023237 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000555318; ENSP00000450428; ENSG00000166888
UCSCiuc058psm.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC023237 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliH0YIY2
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiH0YIY2
PeptideAtlasiH0YIY2
PRIDEiH0YIY2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000555318; ENSP00000450428; ENSG00000166888
UCSCiuc058psm.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000166888.10
HGNCiHGNC:11368 STAT6
OpenTargetsiENSG00000166888
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3667 Eukaryota
ENOG410XPN8 LUCA
GeneTreeiENSGT00760000119236

Miscellaneous databases

ChiTaRSiSTAT6 human

Gene expression databases

BgeeiENSG00000166888 Expressed in 228 organ(s), highest expression level in esophagus
ExpressionAtlasiH0YIY2 baseline and differential

Family and domain databases

Gene3Di3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR036860 SH2_dom_sf
IPR001217 STAT
IPR028187 STAT6_C
PANTHERiPTHR11801 PTHR11801, 1 hit
PfamiView protein in Pfam
PF14596 STAT6_C, 1 hit
SUPFAMiSSF55550 SSF55550, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiH0YIY2_HUMAN
AccessioniPrimary (citable) accession number: H0YIY2
Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: September 12, 2018
This is version 42 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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