UniProtKB - H0YGH5 (H0YGH5_HUMAN)
Protein
Submitted name:
Acetyl-CoA carboxylase 2
Gene
ACACB
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- acetyl-CoA carboxylase activity Source: InterPro
- ATP binding Source: InterPro
GO - Biological processi
- fatty acid biosynthetic process Source: InterPro
Keywordsi
Molecular function | LigaseARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Acetyl-CoA carboxylase 2Imported |
Gene namesi | Name:ACACBImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000076555.15 |
HGNCi | HGNC:85, ACACB |
Expressioni
Gene expression databases
Bgeei | ENSG00000076555, Expressed in parietal pleura and 237 other tissues |
ExpressionAtlasi | H0YGH5, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 362 – 692 | CoA carboxyltransferase N-terminalInterPro annotationAdd BLAST | 331 | |
Domaini | 696 – 859 | CoA carboxyltransferase C-terminalInterPro annotationAdd BLAST | 164 |
Phylogenomic databases
GeneTreei | ENSGT00940000155049 |
Family and domain databases
InterProi | View protein in InterPro IPR034733, AcCoA_carboxyl IPR013537, AcCoA_COase_cen IPR029045, ClpP/crotonase-like_dom_sf IPR011763, COA_CT_C IPR011762, COA_CT_N |
Pfami | View protein in Pfam PF08326, ACC_central, 1 hit PF01039, Carboxyl_trans, 1 hit |
SUPFAMi | SSF52096, SSF52096, 2 hits |
PROSITEi | View protein in PROSITE PS50989, COA_CT_CTER, 1 hit PS50980, COA_CT_NTER, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
H0YGH5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
XMTVPISITN PDLLRHSTEL FMDSGFSPLC QRMGAMVAFR RFEDFTRNFD
60 70 80 90 100
EVISCFANVP KDTPLFSEAR TSLYSEDDCK SLREEPIHIL NVSIQCADHL
110 120 130 140 150
EDEALVPILR TFVQSKKNIL VDYGLRRITF LIAQEKEFPK FFTFRARDEF
160 170 180 190 200
AEDRIYRHLE PALAFQLELN RMRNFDLTAV PCANHKMHLY LGAAKVKEGV
210 220 230 240 250
EVTDHRFFIR AIIRHSDLIT KEASFEYLQN EGERLLLEAM DELEVAFNNT
260 270 280 290 300
SVRTDCNHIF LNFVPTVIMD PFKIEESVRY MVMRYGSRLW KLRVLQAEVK
310 320 330 340 350
INIRQTTTGS AVPIRLFITN ESGYYLDISL YKEVTDSRSG NIMFHSFGNK
360 370 380 390 400
QGPQHGMLIN TPYVTKDLLQ AKRFQAQTLG TTYIYDFPEM FRQALFKLWG
410 420 430 440 450
SPDKYPKDIL TYTELVLDSQ GQLVEMNRLP GGNEVGMVAF KMRFKTQEYP
460 470 480 490 500
EGRDVIVIGN DITFRIGSFG PGEDLLYLRA SEMARAEGIP KIYVAANSGA
510 520 530 540 550
RIGMAEEIKH MFHVAWVDPE DPHKGFKYLY LTPQDYTRIS SLNSVHCKHI
560 570 580 590 600
EEGGESRYMI TDIIGKDDGL GVENLRGSGM IAGESSLAYE EIVTISLVTC
610 620 630 640 650
RAIGIGAYLV RLGQRVIQVE NSHIILTGAS ALNKVLGREV YTSNNQLGGV
660 670 680 690 700
QIMHYNGVSH ITVPDDFEGV YTILEWLSYM PKDNHSPVPI ITPTDPIDRE
710 720 730 740 750
IEFLPSRAPY DPRWMLAGRP HPTLKGTWQS GFFDHGSFKE IMAPWAQTVV
760 770 780 790 800
TGRARLGGIP VGVIAVETRT VEVAVPADPA NLDSEAKIIQ QAGQVWFPDS
810 820 830 840 850
AYKTAQAVKD FNREKLPLMI FANWRGFSGG MKGCLGTWRD VSWWKIRAML
PMHIGEGSV
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketO00763 | ACACB_HUMAN | Acetyl-CoA carboxylase 2 | ACACB ACC2, ACCB | 2,458 | Annotation score: | ||
F8W8T8 | F8W8T8_HUMAN | Acetyl-CoA carboxylase 2 | ACACB | 858 | Annotation score: | ||
F5H5C3 | F5H5C3_HUMAN | Acetyl-CoA carboxylase 2 | ACACB | 143 | Annotation score: | ||
S4R3S7 | S4R3S7_HUMAN | Acetyl-CoA carboxylase 2 | ACACB | 155 | Annotation score: | ||
A0A087WUA1 | A0A087WUA1_HUMAN | Acetyl-CoA carboxylase 2 | ACACB | 112 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC007637 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000538526; ENSP00000443281; ENSG00000076555 |
UCSCi | uc058sxw.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC007637 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
Proteomic databases
MaxQBi | H0YGH5 |
PeptideAtlasi | H0YGH5 |
ProteomicsDBi | 38389 |
Genome annotation databases
Ensembli | ENST00000538526; ENSP00000443281; ENSG00000076555 |
UCSCi | uc058sxw.1, human |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000076555.15 |
HGNCi | HGNC:85, ACACB |
OpenTargetsi | ENSG00000076555 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000155049 |
Miscellaneous databases
ChiTaRSi | ACACB, human |
Gene expression databases
Bgeei | ENSG00000076555, Expressed in parietal pleura and 237 other tissues |
ExpressionAtlasi | H0YGH5, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR034733, AcCoA_carboxyl IPR013537, AcCoA_COase_cen IPR029045, ClpP/crotonase-like_dom_sf IPR011763, COA_CT_C IPR011762, COA_CT_N |
Pfami | View protein in Pfam PF08326, ACC_central, 1 hit PF01039, Carboxyl_trans, 1 hit |
SUPFAMi | SSF52096, SSF52096, 2 hits |
PROSITEi | View protein in PROSITE PS50989, COA_CT_CTER, 1 hit PS50980, COA_CT_NTER, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | H0YGH5_HUMAN | |
Accessioni | H0YGH5Primary (citable) accession number: H0YGH5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 22, 2012 |
Last sequence update: | February 22, 2012 | |
Last modified: | October 7, 2020 | |
This is version 51 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |