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Protein

Histone H2A

Gene

H2AFJ

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H2AUniRule annotation
Gene namesi
Name:H2AFJImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000246705.4
HGNCiHGNC:14456 H2AFJ

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleosome coreUniRule annotation, NucleusUniRule annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000246705

PTM / Processingi

Proteomic databases

PeptideAtlasiH0YFX9
PRIDEiH0YFX9

Expressioni

Gene expression databases

BgeeiENSG00000246705 Expressed in 206 organ(s), highest expression level in left testis
ExpressionAtlasiH0YFX9 baseline and differential

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.UniRule annotation

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliH0YFX9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 52HistoneInterPro annotationAdd BLAST47
Domaini55 – 88Histone_H2A_CInterPro annotationAdd BLAST34

Sequence similaritiesi

Belongs to the histone H2A family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1756 Eukaryota
COG5262 LUCA
GeneTreeiENSGT00910000143981

Family and domain databases

CDDicd00074 H2A, 1 hit
Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR009072 Histone-fold
IPR002119 Histone_H2A
IPR007125 Histone_H2A/H2B/H3
IPR032454 Histone_H2A_C
PfamiView protein in Pfam
PF00125 Histone, 1 hit
PF16211 Histone_H2A_C, 1 hit
PRINTSiPR00620 HISTONEH2A
SMARTiView protein in SMART
SM00414 H2A, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

H0YFX9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
GNYAERVGAG APVYLAAVLE YLTAEILELA GNAARDNKKT RIIPRHLQLA
60 70 80 90
IRNDEELNKL LGKVTIAQGG VLPNIQAVLL PKKTESQKTK SK
Length:92
Mass (Da):9,976
Last modified:February 22, 2012 - v1
Checksum:iFB7FA3E48559412A
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9BTM1H2AJ_HUMAN
Histone H2A.J
H2AFJ
129Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010168 Genomic DNA No translation available.
KF455607 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000501744; ENSP00000440902; ENSG00000246705
UCSCiuc058lmt.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010168 Genomic DNA No translation available.
KF455607 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliH0YFX9
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiH0YFX9
PRIDEiH0YFX9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000501744; ENSP00000440902; ENSG00000246705
UCSCiuc058lmt.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000246705.4
HGNCiHGNC:14456 H2AFJ
OpenTargetsiENSG00000246705
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1756 Eukaryota
COG5262 LUCA
GeneTreeiENSGT00910000143981

Gene expression databases

BgeeiENSG00000246705 Expressed in 206 organ(s), highest expression level in left testis
ExpressionAtlasiH0YFX9 baseline and differential

Family and domain databases

CDDicd00074 H2A, 1 hit
Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR009072 Histone-fold
IPR002119 Histone_H2A
IPR007125 Histone_H2A/H2B/H3
IPR032454 Histone_H2A_C
PfamiView protein in Pfam
PF00125 Histone, 1 hit
PF16211 Histone_H2A_C, 1 hit
PRINTSiPR00620 HISTONEH2A
SMARTiView protein in SMART
SM00414 H2A, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiH0YFX9_HUMAN
AccessioniPrimary (citable) accession number: H0YFX9
Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: September 12, 2018
This is version 42 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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