UniProtKB - H0YFV4 (H0YFV4_HUMAN)
Protein
Submitted name:
ATP-binding cassette sub-family C member 9
Gene
ABCC9
Organism
Homo sapiens (Human)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 332 – 339 | ATPPROSITE-ProRule annotation | 8 | |
Nucleotide bindingi | 973 – 980 | ATPPROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ATPase activity Source: InterPro
- ATPase-coupled transmembrane transporter activity Source: InterPro
- ATP binding Source: UniProtKB-UniRule
- sulfonylurea receptor activity Source: InterPro
GO - Biological processi
- potassium ion transport Source: InterPro
Keywordsi
Biological process | TransportARBA annotation |
Ligand | ATP-bindingPROSITE-ProRule annotationARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Submitted name: ATP-binding cassette sub-family C member 9Imported |
Gene namesi | Name:ABCC9Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:60, ABCC9 |
VEuPathDBi | HostDB:ENSG00000069431.10 |
Subcellular locationi
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 14 – 32 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 87 – 112 | HelicalSequence analysisAdd BLAST | 26 | |
Transmembranei | 118 – 137 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 195 – 219 | HelicalSequence analysisAdd BLAST | 25 | |
Transmembranei | 239 – 259 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 609 – 626 | HelicalSequence analysisAdd BLAST | 18 | |
Transmembranei | 661 – 684 | HelicalSequence analysisAdd BLAST | 24 | |
Transmembranei | 754 – 776 | HelicalSequence analysisAdd BLAST | 23 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | ENSG00000069431, Expressed in heart and 155 other tissues |
ExpressionAtlasi | H0YFV4, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 260 | ABC transmembrane type-1InterPro annotationAdd BLAST | 260 | |
Domaini | 300 – 539 | ABC transporterInterPro annotationAdd BLAST | 240 | |
Domaini | 622 – 900 | ABC transmembrane type-1InterPro annotationAdd BLAST | 279 | |
Domaini | 939 – 1173 | ABC transporterInterPro annotationAdd BLAST | 235 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 571 – 594 | DisorderedSequence analysisAdd BLAST | 24 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 577 – 593 | AcidicSequence analysisAdd BLAST | 17 |
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000156680 |
HOGENOMi | CLU_000604_27_9_1 |
Family and domain databases
Gene3Di | 1.20.1560.10, 2 hits |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR011527, ABC1_TM_dom IPR036640, ABC1_TM_sf IPR003439, ABC_transporter-like IPR017871, ABC_transporter_CS IPR001475, ABCC9 IPR027417, P-loop_NTPase |
PANTHERi | PTHR24223:SF173, PTHR24223:SF173, 1 hit |
Pfami | View protein in Pfam PF00664, ABC_membrane, 2 hits PF00005, ABC_tran, 2 hits |
PRINTSi | PR01094, SULFNYLUR2 |
SMARTi | View protein in SMART SM00382, AAA, 2 hits |
SUPFAMi | SSF52540, SSF52540, 2 hits SSF90123, SSF90123, 2 hits |
PROSITEi | View protein in PROSITE PS50929, ABC_TM1F, 2 hits PS00211, ABC_TRANSPORTER_1, 2 hits PS50893, ABC_TRANSPORTER_2, 2 hits |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
H0YFV4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
ISETLSSKEF LENAYVLAVL LFLALILQRT FLQASYYVTI ETGINLRGAL
60 70 80 90 100
LAMIYNKILR LSTSNLSMGE MTLGQINNLV AIETNQLMWF LFLCPNLWAM
110 120 130 140 150
PVQIIMGVIL LYNLLGSSAL VGAAVIVLLA PIQYFIATKL AEAQKSTLDY
160 170 180 190 200
STERLKKTNE ILKGIKLLKL YAWEHIFCKS VEETRMKELS SLKTFALYTS
210 220 230 240 250
LSIFMNAAIP IAAVLATFVT HAYASGNNLK PAEAFASLSL FHILVTPLFL
260 270 280 290 300
LSTVVRFAVK AIISVQKLNE FLLSDEIGDD SWRTGESSLP FESCKKHTGV
310 320 330 340 350
VTNGYFSWGS GLATLSNIDI RIPTGQLTMI VGQVGCGKSS LLLAILGEMQ
360 370 380 390 400
TLEGKVHWSN VNESEPSFEA TRSRNRYSVA YAAQKPWLLN ATVEENITFG
410 420 430 440 450
SPFNKQRYKA VTDACSLQPD IDLLPFGDQT EIGERGINLS GGQRQRICVA
460 470 480 490 500
RALYQNTNIV FLDDPFSALD IHLSDHLMQE GILKFLQDDK RTLVLVTHKL
510 520 530 540 550
QYLTHADWII AMKDGSVLRE GTLKDIQTKD VELYEHWKTL MNRQDQELEK
560 570 580 590 600
DMEADQTTLE RKTLRRAMYS REAKAQMEDE DEEEEEEEDE DDNMSTVMRL
610 620 630 640 650
RTKMPWKTCW RYLTSGGFFL LILMIFSKLL KHSVIVAIDY WLATWTSEYS
660 670 680 690 700
INNTGKADQT YYVAGFSILC GAGIFLCLVT SLTVEWMGLT AAKNLHHNLL
710 720 730 740 750
NKIILGPIRF FDTTPLGLIL NRFSADTNII DQHIPPTLES LTRSTLLCLS
760 770 780 790 800
AIGMISYATP VFLVALLPLG VAFYFIQKYF RVASKDLQEL DDSTQLPLLC
810 820 830 840 850
HFSETAEGLT TIRAFRHETR FKQRMLELTD TNNIAYLFLS AANRWLEVRT
860 870 880 890 900
DYLGACIVLT ASIASISGSS NSGLVGLGLL YALTITNYLN WVVRNLADLE
910 920 930 940 950
VQMGAVKKVN SFLTMESENY EGTMDPSQVP EHWPQEGEIK IHDLCVRYEN
960 970 980 990 1000
NLKPVLKHVK AYIKPGQKVG ICGRTGSGKS SLSLAFFRMV DIFDGKIVID
1010 1020 1030 1040 1050
GIDISKLPLH TLRSRLSIIL QDPILFSGSI RFNLDPECKC TDDRLWEALE
1060 1070 1080 1090 1100
IAQLKNMVKS LPGGLDAVVT EGGENFSVGQ RQLFCLARAF VRKSSILIMD
1110 1120 1130 1140 1150
EATASIDMAT ENILQKVVMT AFADRTVVTI AHRVSSIMDA GLVLVFSEGI
1160 1170
LVECDTVPNL LAHKNGLFST LVMTNK
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketO60706 | ABCC9_HUMAN | ATP-binding cassette sub-family C m... | ABCC9 SUR2 | 1,549 | Annotation score: | ||
Q8N4N7 | Q8N4N7_HUMAN | ABCC9 protein | ABCC9 | 149 | Annotation score: | ||
G3V1N6 | G3V1N6_HUMAN | ATP-binding cassette sub-family C m... | ABCC9 hCG_24790 | 170 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC008250 Genomic DNA No translation available. AC084806 Genomic DNA No translation available. KF459680 Genomic DNA No translation available. KF495813 Genomic DNA No translation available. KF570253 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000544039; ENSP00000440521; ENSG00000069431 |
UCSCi | uc058lvx.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC008250 Genomic DNA No translation available. AC084806 Genomic DNA No translation available. KF459680 Genomic DNA No translation available. KF495813 Genomic DNA No translation available. KF570253 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | H0YFV4 |
PRIDEi | H0YFV4 |
ProteomicsDBi | 38193 |
Protocols and materials databases
Antibodypediai | 12381, 223 antibodies |
Genome annotation databases
Ensembli | ENST00000544039; ENSP00000440521; ENSG00000069431 |
UCSCi | uc058lvx.1, human |
Organism-specific databases
HGNCi | HGNC:60, ABCC9 |
OpenTargetsi | ENSG00000069431 |
VEuPathDBi | HostDB:ENSG00000069431.10 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000156680 |
HOGENOMi | CLU_000604_27_9_1 |
Miscellaneous databases
ChiTaRSi | ABCC9, human |
Gene expression databases
Bgeei | ENSG00000069431, Expressed in heart and 155 other tissues |
ExpressionAtlasi | H0YFV4, baseline and differential |
Family and domain databases
Gene3Di | 1.20.1560.10, 2 hits |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR011527, ABC1_TM_dom IPR036640, ABC1_TM_sf IPR003439, ABC_transporter-like IPR017871, ABC_transporter_CS IPR001475, ABCC9 IPR027417, P-loop_NTPase |
PANTHERi | PTHR24223:SF173, PTHR24223:SF173, 1 hit |
Pfami | View protein in Pfam PF00664, ABC_membrane, 2 hits PF00005, ABC_tran, 2 hits |
PRINTSi | PR01094, SULFNYLUR2 |
SMARTi | View protein in SMART SM00382, AAA, 2 hits |
SUPFAMi | SSF52540, SSF52540, 2 hits SSF90123, SSF90123, 2 hits |
PROSITEi | View protein in PROSITE PS50929, ABC_TM1F, 2 hits PS00211, ABC_TRANSPORTER_1, 2 hits PS50893, ABC_TRANSPORTER_2, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | H0YFV4_HUMAN | |
Accessioni | H0YFV4Primary (citable) accession number: H0YFV4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 22, 2012 |
Last sequence update: | February 22, 2012 | |
Last modified: | February 10, 2021 | |
This is version 70 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |